Abstract:DESCRIPTION (provided by applicant): Organ transplantation is one of the great success stories of modern medicine. However, the supply of suitable organs lags far behind the need and many patients die while waitlisted for organs. Current practice involves
donor preconditioning to stabilize organs… more
Abstract:This Small Business Innovation Research Phase I research project will use femtosecond laser machining to fabricate Lithium ion based nanobatteries composed of arrays of nanocells. In addition, an array of addressable batteries will also be constructed. A femtosecond laser is a powerful tool to… more
Abstract:The proposed approach for Phase I of this effort brings together two key items that are needed to work in concert with one another: advanced fatigue assessment methods and non-destructive inspection & detection techniques. Successful synthesis of these elements and the engineering disciplines behind… more
Abstract:The USAF recognizes that benefits to cold working fastener holes include significantly increased life of a structure subjected to fatigue loading. However, full realization of this potential from a maintenance and engineering standpoint is hindered by the fact that there is currently no adequate… more
Abstract:DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for treatment of acute myocardial infarction. This enzyme strongly inhibits platelet activation and aggregation with modest bleeding risk. Using a protein informatics
approach, we have successfully engineered… more
Abstract:DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy to prevent or reduce ischemia-reperfusion injury during lung transplantation. The enzyme strongly preserves vascular integrity and inhibits platelet activation and agg
regation without increasing bleeding risk.… more
Abstract:DESCRIPTION (provided by applicant): To increase the effectiveness of chronic disease prevention and health promotion interventions, researchers and practitioners must work collaboratively to ensure that evidence-based approaches are translated into public
ly accessible tools and resources. To… more
Abstract:This Small Business Innovation Research (SBIR) Phase I proposal describes a heat spreader embedded with a nanolfuid oscillating heat pipe (OHP) that will meet the cooling needs of high power density electronics by utilizing: 1) the extra-high heat transfer coefficient of thin film evaporation; 2)… more
Abstract:The Phase I objective is a conceptual design of a hyperspectral/multimodal fundus camera for assessing laser damage. The premise to be ultimately proven in this project is that damage to the fundus, from laser irradiation, may be characterized and detected by reflectance spectra, and by measuring… more
Abstract:DESCRIPTION (provided by applicant): Lung fibrosis, a group of incurable lung diseases with high mortality rates, is characterized by inflammatory cell infiltration, fibroblast proliferation, and excessive deposition of extracellular matrix proteins (ECM)
in lung parenchyma. Globally, five million… more
Abstract:We propose to run 3 experiments to refine and utilize measures of oculomotor activity and pupil diameter change to assess an individual's malicious or deceptive intent. We also propose to concurrently develop the software and determine the hardware necessary for online, real-time assessment of… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer (STTR) Phase II research project will develop and apply a principled design methodology to confront the serious problems associated with deep sub-micron,… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer (STTR) Phase II project focuses on developing a commercially viable process for producing a versatile passive radio frequency identification (RFID) tag. … more
Abstract:Bugeye Technologies' concept that a low-cost visual display system with 20/20 acuity using Commercial Off the Shelf (COTS) parts is achievable was validated in Phase I. The technology utilizes an optical element and flat panel display to create a visual module. Multiple visual modules could be… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will use RNA interference (RNAi) to limit damage to corn from the plant parasite lesion nematode by silencing genes in the parasite. Phase I demonstrated in culture that expression of specific double-stranded RNAs (dsRNAs) from lesion… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes the improvement of real-time PCR, a DNA-based rapid-detection method, for detection of food-borne pathogens such as Salmonella. Current methods are inadequate to accurately detect pathogens in foods such as chocolate,… more
Abstract:The development of very small, versatile, rugged, low power, low noise, one or three-axis short-period seismometers is needed to monitor nuclear detonations. Specifications include total sensor size less than 1 cubic inch, low power consumption, low sensor self noise below the USGS Low Earth Noise… more
Abstract:DESCRIPTION (provided by applicant): Thromboembolic disorders are major causes of morbidity and mortality in the Western societies. Anticoagulants are pivotal agents in the prevention and treatment of arterial and venous thrombosis. The limitations of curr
ently approved anticoagulant drugs have… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer Phase I project will test the feasibility of producing lightweight building materials from fly ash, suitable for making roofing tiles, wall boards and insulation… more
Abstract:Most biomass materials, such as switchgrass and corn stover, are very bulky (fluffy) when first collected,making them costly to handle, store, and transport. Current densification methods ¿ include baling, pelletizing, etc, ¿ are too costly, too energy-intensive, or both. A better method to… more
Abstract:DESCRIPTION (provided by applicant): This grant will seek to develop a methodology that will allow us to test whether a promising new class of drugs for Alzheimer's disease is having the desired effect in the human brain. This methodology will allow pharma
ceutical companies to make informed… more
Abstract:The Missions and Means Framework (MMF) has been primarily used to examine and develop combat operation models that examine the matching of military tasks associated with the combat operations in question with the military means needed to successfully achieve those objectives. For a military… more
Abstract:DESCRIPTION (provided by applicant): Visualization of Medication Regimens to Improve Mental Health Care Iconic Health, LLC has conceptually developed Medication IconoGraphs, a patent pending set of visualization tools to assist mental health providers mana
ge complex medication regimens. IconoGraphs… more
Abstract:DESCRIPTION (provided by applicant): The long term goal of this research is to develop an efficient method to authenticate rodent cell lines. Misidentification as well as inter- and intra-species cross contamination of cell lines is widespread and has a su
bstantial negative impact on biomedical… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Innovation Research (SBIR) Phase I project submitted by Mo-Sci Corp. proposes to develop a novel synthetic bone tissue scaffold manufactured by selective laser sintering (SLS) to… more
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