Abstract:DESCRIPTION (provided by applicant): Calcium phosphate cements (CPCs) are used in orthopedic surgery as bone filler and have been proved with very good biocompatibility. However, the inadequate mechanical properties have significantly impeded their clinica
l applications despite of the good… more
Abstract:DESCRIPTION (provided by applicant): The broad, long-term objective of the proposed research is to develop a software product that can be used to facilitate the analysis of genetic changes in order to elucidate chromosomal abnormalities that underlie disea
ses such as autism spectrum disorder,… more
Abstract:The noise from turbulent, hot, supersonic jets during take-off and landing, as well as high-Mach cruise at altitude, dominates noise emanating from other powerplant components (e.g., fan, combustor). This intense noise has significant safety implications for launch personnel as well an… more
Abstract:This proposal will develop new filter and guidance algorithms and demonstrate their effectiveness in a 6 degrees-of-freedom missile-target simulator. The new algorithms for the filters will be based on a)optimal estimation b)sliding mode c) neural networks and d)partcle filters. The guidance… more
Abstract:The overarching objective of the proposed research and development work is to create a new type of our miniature, autonomous, explosive-driven high-power microwave source that provides multiple radiation pulses. Each system will be a complete unit that will include all components necessary for… more
Abstract:The objective of the proposed research and development work is to create new types of compact, autonomous explosive-driven high-power microwave (HPM) systems based on the magnetic flux compression generator (FCG). There will be no moving parts (to include armatures) in these devices; the systems… more
Abstract:DESCRIPTION (provided by applicant): Detection and quantification of proteins in various biological samples is one of the most important and most often utilized assays with applications in research, medical diagnosis, early disease detection and detection
of biological threat agents. While many… more
Abstract:DESCRIPTION (provided by applicant): Diabetes has reached epidemic proportions in the United States resulting in expenditures of over 90B per year. The enormity of the potential market inspired many pharmaceutical companies to enter the field but success
has proven difficult. The reason for this… more
Abstract:Terbium and Europium doped glasses will be investigated for tunable lasing from 450 nm to 490 nm. They will be pumped by Q-switched frequency tripled 355 nm Nd laser pulses. The Tb materials will also be evaluated for 375 nm laser diode pumping.
Abstract:This Small Business Innovation Research Phase I project will fabricate solar-blind UV detectors (SBDs) using BeZnO, a new wide bandgap semiconductor material developed by the proposing company, MOXtronics, Inc. These SBDs would be very sensitive and efficient for detection of UV radiation in the… more
Abstract:This SBIR Phase I research proposal will analyze, develop, and demonstrate a novel, optimized, high power density and high efficiency electric motor technology capable of operating at high speeds using Parallel Magnetic Circuit (PMC) technology. PMC technology is a breakthrough magnetic force… more
Abstract:ABSTRACT: The successful culmination of this work will result in development of a highly directional integrated, photoconductive switch and source-antenna system that will generate high power THz radiation for a myriad of defense, homeland security, and civilian applications: including the ability… more
Abstract:The proposed solid-state "Photon Initiated Thyristor Switches" are a low risk approach that offer an outstanding opportunity to fulfill the near term switching requirements for numerous DoD systems including many of those pertinent to High Power Microwave sources for crucial Directed Energy… more
Abstract:The International Linear Collider and other accelerator applications require fast, high voltage, high current switches that are compact, robust, and efficient, and that can operate reliably at high repetition rates and modest duty cycles for long lifetimes. This project will demonstrate the… more
Abstract:DESCRIPTION (provided by applicant): Treating cancer is clearly a very difficult process, and while progress has been made, much work remains to be done. The failures of many seemingly promising compounds to meet expectations have taught us that we must ag
gressively continue to develop new,… more
Abstract:Commercial nuclear power currently generates approximately 20 percent of the electricity consumed in the United States. As such, the 104 operating light water reactor (LWR) plants constitute the single largest domestic source of energy production that does not emit carbon dioxide (CO2) or other… more
Abstract:The future use of coal, which is projected to remain a mainstay of energy consumption well into the 21st century, will require efficient, low emission ultra-supercritical coal-fired boilers. The high operating temperature, along with the oxidizing, corroding, and slag-deposition-induced… more
Abstract:DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) is a hepatotropic DNA virus that replicates by reverse transcription. It chronically infects over 350 million people worldwide and causes 600,000 deaths annually. Current therapies for HBV infect
ion use interferon 1 or one of five… more
Abstract:By drastically reducing the physical footprint of a mass spectrometer to the size of a beverage can, Ceramitron could set a new performance/price standard in the miniaturized MS market. To do this, we propose eliminating the turbomolecular and roughing pumps in favor two chemical sorption pumps (a… more
Abstract:The USAF recognizes that benefits to cold working fastener holes include significantly increased life of a structure subjected to fatigue loading. However, full realization of this potential from a maintenance and engineering standpoint is hindered by the fact that there is currently no adequate… more
Abstract:DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for inhibition of cancer metastasis. The enzyme strongly inhibits platelet activation and aggregation without increasing bleeding risk. Using a protein informatics app
roach, we have successfully engineered an… more
Abstract:DESCRIPTION (provided by applicant): The main objective of this SBIR Phase I research is to develop and test a software prototype. The prototype will lead to a software product. It will be a clinical tool that helps clinicians to assess the condition of pa
tients who are at risk of or who have… more
Abstract:DESCRIPTION (provided by applicant): Indocyanine Green (ICG) and Sodium Fluorescein (SF) are fluorescent dyes used clinically in eye fundus imaging, primarily for detecting vascular abnormalities in the retina and choroid, which is the layer behind the ret
ina. It is used with the Heidelberg Retinal… more
Abstract:DESCRIPTION (provided by applicant): Diabetes mellitus afflicts 20.8 million people, or 7% of the population, in the United States. Fifteen percent, or 2.4 million people, will develop diabetic foot ulcers in their life time. Diabetic foot ulceration and i
nfections are a major cause of… more
Abstract:We are utilizing the output from eye trackers to develop procedures to identify momentary lapses in alertness. The intent to deceive should be associated with the converse, momentary increases in alertness. We review literature dealing with the issue of deception as reflected in: pupil diameter,… more
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