Abstract:DESCRIPTION (provided by applicant): Diabetes mellitus afflicts 20.8 million people, or 7% of the population, in the United States. Fifteen percent, or 2.4 million people, will develop diabetic foot ulcers in their life time. Diabetic foot ulceration and i
nfections are a major cause of… more
Abstract:We are utilizing the output from eye trackers to develop procedures to identify momentary lapses in alertness. The intent to deceive should be associated with the converse, momentary increases in alertness. We review literature dealing with the issue of deception as reflected in: pupil diameter,… more
Abstract:This Small Business Technology Transfer Phase I research project will demonstrate a globally asynchronous, locally synchronous (GALS) methodology for the design of large-scale, deep-submicron, System-on-Chip (SoC) integrated circuits fabricated in Field-Programmable Gate Arrays (FPGAs). The… more
Abstract:In this Phase I SBIR program, Brewer Science, Inc. (BSI), a leader in innovative microelectronic materials, and our pioneering additive manufacturing partner will develop and demonstrate a cost-effective materials production process for fabricating high-performance thin-film transistors (TFTs) using… more
Abstract:DESCRIPTION (provided by applicant): Current emphasis on metabolic approaches and models for diagnosing heart disease have renewed development of 123I SPECT imaging agents applied in stand-alone protocols and as a complimentary role to existing stress/rest
perfusion protocols. However, a majority… more
Abstract:Non Technical Summary: The goal of this research is to generate transgenic crops with broad-spectrum, season-long resistance to root knot nematode (RKN, Meloidogyne sp.). Plant parasitic nematodes, of which RKN is the most significant, annually cause damage of $8 billion in the U.S. and $78 billion… more
Abstract:Non Technical Summary: Current estimates indicate that one-third of worldwide agricultural output is lost to pests and diseases such as pathogenic fungi. Despite advancements in chemical control, the rapid onset of resistance to pesticides often limits their utility. In addition, the vast majority… more
Abstract:DESCRIPTION (provided by applicant): Parasitic infect over 140 million people, with up to one billion at risk in 80 countries. Lymphatic filariasis creates an enormous health and economic burden within affected areas and is the second leading cause of long
-term disability. In 2000, international… more
Abstract:DESCRIPTION (provided by applicant): Invasive fungal infections are an increasingly common and serious cause of illness and death in the U.S. and worldwide. Infection by Candida albicans has increased tenfold to become more frequent than diseases caused by
E. coli and Pseudomonas, and it has become… more
Abstract:The goal of this research is to generate crops, such as tomato, corn and carrot, with broad spectrum, season long resistance to root knot nematode. Plant parasitic nematodes, of which root knot is the most significant, annually cause damage in excess of $8 billion in the U.S. and $80 billion… more
Abstract:The development of very small, versatile, rugged, low power, low noise, one-or-three-axis short-period seismometers is needed to monitor nuclear detonations. Specifications include total sensor size less than 1 cubic inch, low power consumption, low sensor self-noise below the USGS Low Earth Noise… more
Abstract:The principal objective of the proposed Phase I SBIR project is the development of a reliable predictive capability for the evaluation of flaw tolerance in metallic and composite airframe components, given part specifications, material properties, initial flaws, such as voids, inclusions,… more
Abstract:This Small Business Technology Transfer Phase I project focuses on lameness which is one of the most common health problems for horses. Treatment is most effective in the earliest stages of lameness, however the subjective diagnostic methods currently used by large animal are imprecise and… more
Abstract:This Small Business Innovation Research (SBIR) Phase I research project aims to improve the frequency of homologous recombination by increasing the number of targeting vector molecules that reach the nucleus. The technology is based on constructing targeting vectors that have proteins involved in… more
Abstract:IconoPsych Care, LLC is working toward commercialization of web-based mental health services which integrate the practice of video telepsychiatry with electronic medical record keeping. This research and development effort is in response to three problems: 1) the shortage of mental health providers… more
Abstract:DESCRIPTION (provided by applicant): One of the most expensive aspects of a cryopreservation program is related to ongoing, long-term storage and shipping of samples at very low temperatures (typically between - 196oC, the temperature of liquid nitrogen (L
N2), and approximately -120oC, in the high-… more
Abstract:MO-SCI Corporation and the Missouri University of Science & Technology (MST-formerly University of Missouri-Rolla) propose to develop low cost, IR retro-reflective (800 nm - 2800 nm), visible absorbing glass microspheres for ubiquitous spectroscopic tagging through our innovative material design,… more
Abstract:Mo-Sci Corporation and the Missouri University of Science&Technology (MS&T) propose to develop novel high-strength and optically transparent glass ribbon reinforced polymer matrix composites as light-weight structural components, by layering and processing a polymer matrix reinforced with… more
Abstract:In this Phase I SBIR contract, Nanoparticle Biochem Inc (NBI) proposes to develop commercially viable synthetic methodology for the production of multifunctional gold Nanoparticle-bombesin conjugate. Gold Nanoparticle-bombesin (AuNP-BBN) conjugate is a pot ential clinical imaging and therapeutic… more
Abstract:The objective of this proposal is to develop nanoparticulate therapeutic products from the readily injectable Gold-198 (Au-198) nanoconstructs invented at the University of Missouri and licensed to Nanoparticle Biochem, Inc. The Phase I effort embodies thr ee aims: (1) Optimization of synthetic… more
Abstract:We are proposing an approach to the use of CFD that will include the determination of large scale unsteadiness in the flow over the weapons bay. The effects of release of the weapon, the unsteady aerodynamic forces on a given weapon as it leaves the bay and its continued descent will be determined.… more
Abstract:DESCRIPTION (provided by applicant): The pharmaceutical industry is under mounting pressure to reinvent itself due to high failure rates in the clinic and exorbitant research costs. Larger research and development budgets have not yielded the promised incr
ease in medicines entering the marketplace.… more
Abstract:DESCRIPTION (provided by applicant): Cancer continues to be a growing health issue. Overall five-year survival rates have changed only marginally over the past three decades and success rates in putting cancer drugs through the clinic have not improved. Th
ese facts highlight an unmet need not only… more
Abstract:DESCRIPTION (provided by applicant): The pharmaceutical industry has access to well-designed clinical trial management software (CTMS) for their studies. Specialized CTMS packages are essential for drug trials but are not optimal for other kinds of clinica
l research, such as observational,… more
Abstract:The primary objective of the Phase II research and development is to scale-up the production of components of nanoengineered thermites (or, nanothermites) in pound quantities in a safe manner. In Phase I, we have achieved the proof-of-concepts for the synthesis of several nanoscale oxides, assembly… more
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