Abstract:As a consequence of climate change, it is predicted that periods of agriculturally significant environmental stress conditions due to high temperatures will occur more frequently by the end of the century. These conditions are expected to pose a significant threat to global agricultural productivity… more
Abstract:This Small Business Technology Transfer Phase I project will result in the development of a scalable prototype technology to transform swine manure into a sustainable alternative for petroleum-based construction adhesives. Thermochemical liquefaction processing of swine manure will be used to… more
Abstract:DESCRIPTION (provided by applicant): Myopathies and other clinical disorders arising from genetic abnormalities of the mitochondrial respiratory chain collectively affect as many as 1 in 8000 individuals, representing in aggregate a significant disease burden, even though the specific underlying… more
Abstract:DESCRIPTION (provided by applicant): Through modern surgical advancements, total hip replacements (THR) have become one of the most successful implant procedures to date. Even though long-term success rates are high, the staggering number of THR proceduresper annum (~200,000 in the United States… more
Abstract:DESCRIPTION (provided by applicant): Cryopreserved hepatocytes are widely used in drug development as pharmaceutical companies strive to identify risk pre-clinically and shift product attrition to the earliest stages of drug discovery. Unlike immortalizedcell lines, primary hepatocytes possess the… more
Abstract:DESCRIPTION (provided by applicant): Hepcidin is the peptide hormone responsible for regulating circulating iron concentrations. Overexpression of hepcidin results in severe iron deficiency and anemia, whereas hepcidin deficiency leads to iron overload. Not surprisingly, abnormalities in hepcidin… more
Abstract:DESCRIPTION (provided by applicant): Inflammatory Bowel Disease (IBD), comprised primarily of ulcerative colitis (UC) and Crohn's disease (CD), is characterized by a chronic, uncontrolled inflammation of the intestinal mucosa. As many as 1.4 Million peoplein the United States and 2.2 Million… more
Abstract:DESCRIPTION (provided by applicant): In order to reduce the cost of bringing a new drug to market, drug candidates with a high probability for failure must be identified early in their development. The pharmaceutical industry employs in vitro liver modelsto screen new drugs for undesirable toxic… more
Abstract:SUMMARY/ABSTRACT Fine-needle aspiration (FNA) cytology is the standard technique for evaluating thyroid nodules. Hemorrhaging is common during the procedure, however, leading to an aspirate that is diluted by blood. Subsequent slide preparations are oftensuboptimal, resulting in nondiagnostic… more
Abstract:DESCRIPTION (provided by applicant): We will develop the first assay for multiplexed combinations of all 14 Bone Morphogenetic Proteins. Immunoassays are the gold standard for measuring proteins in clinical samples. However these antibody- based tests neither quantitate protein analyte variants,… more
Abstract:DESCRIPTION (provided by applicant): Burn injuries and chronic wounds present a significant burden to patients and the US healthcare system. Each year in the US, there are 450,000 burns that require medical treatment and 45,000 burn patients that require hospitalization. The mortality rate… more
Abstract:DESCRIPTION (provided by applicant): Polychromatic flow cytometry [FC] is one of the most powerful analytical techniques routinely used in immunology. Flow cytometry plays a critical role in several growing clinical applications: leukemia and lymphoma immunophenotyping for diagnosis and… more
Abstract:DESCRIPTION (provided by applicant): There are now 50+ new drugs in Phase II-III development to treat COPD - a disease affecting 13 million Americans, costing 49B and killing 120,000 each year. However, a major limitation in evaluating therapies for thesechronic diseases is the lack of a… more
Abstract:DESCRIPTION (provided by applicant): Cigarette smoking remains the number one cause of preventable morbidity and mortality in the U.S. Each year, one third to one half of smokers attempt to quit at least once; however, approximately 94% of quit attempts fail. A number of interventions have been… more
Abstract:During covert operations, the U.S. Army may be required to breach a concrete structure using a controlled explosion. When choosing the most effective charge size and placement, it is vital to perform a rapid field assessment of the material and structural properties of the target structure. However,… more
Abstract:While many inspection technologies are available to find corrosion in steel tendons of prestressed concrete, no single technology has shown consistent results over the wide range of prestressed structures and inspection settings that are required from the bridge infrastructure market. However, a new… more
Abstract:Current and next-generation power systems require power devices that operate at high voltages and high frequencies beyond the reliable operating limit of the present silicon- and silicon carbide-based power devices. The material properties of AlN permit power devices to operate at these extremes,… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project seeks to develop a novel holographic microscope system for examining cytological samples, such as blood smears, at the point of care. Current blood cell analysis techniques require manual examination by expert technicians, resulting in a… more
Abstract:DESCRIPTION (provided by applicant): Loss of voluntary control over bladder and bowel function as a result of spinal cord injury (SCI) has profound impact on the mental and physical health status and quality of life of patients. It is estimated that 270,000 people in the USA have SCI ((https://www… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will build a state of the art imaging tool for rodent disease quantification using ultrasound. Hundreds of millions of dollars in the US are spent annually on preclinical drug efficacy studies, as all candidate cancer therapeutics must… more
Abstract:The proposed effort will extend existing proofs of concept and advanced research systems to: (a) provide an efficient, low-level, data-parallel runtime for graph processing on GPUs; (b) provide a high-level abstraction for writing graph analytics that are
Abstract:The Cyber Battle Damage Assessment Tool (CyBDAT) will allow warfighters to quantify the probabilities associated with CNA, CNE and EA and facilitate for the direct comparison of cyber attacks to kinetic attacks in mission planning. CyBDAT creates a directed graph Markov attack model of the cyber… more
Abstract:Visual Analytics Managers (VAMs) for Cyber-Physical Systems (CPS) will allow users to gain insight into the CPS with state-of-the-art analytics and artificial intelligence and provide human-in-the-loop interaction with the CPS. Our VAM toolkit builds around a Scala Akka actor framework, allowing… more
Abstract:DESCRIPTION (provided by applicant): The objective of this STTR proposal is to develop a 2-D diffusion point-of-care assay (POC) for B-type natriuretic peptide (BNP). The primary goal of the proposed work is to create a test format that will allow patientswith chronic heart failure to … more
Abstract:DESCRIPTION (provided by applicant): Harmful algal blooms (HABs) are becoming frequent occurrences off the coasts of the United States, particularly in coastal waters of New England, the Gulf of Mexico, and the Pacific Ocean. Historically, HABs have beenassociated with fish kills and marine mammal… more
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