Abstract:DESCRIPTION (provided by applicant): The goal of this research is to develop a new approach to bring diagnosis and monitoring tests for HIV to the primary care level (primary care provider office, small healthcare clinics and labs, and community health center labs) by introducing a multi-functional… more
Abstract:The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project is to provide a tool for designing new drugs. Designing new drugs that bind to a specified protein target required finding the best molecule in a vast chemical space. The proposed design tool can search… more
Abstract:DESCRIPTION (provided by applicant): The objective of the proposed project is to advance the development of novel peptides targeting MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) protein as platform drug molecules for the treatment of Acute Lung Injury (ALI) and its more severe form, Acute… more
Abstract:Glaucoma is the leading cause of irreversible blindness worldwide and the leading cause of blindness in African Americans. Research shows that the prevalence of glaucoma is expected to increase by 50% in the next 15 years. Although medical treatment with topical eye drops can be effective at… more
Abstract:For sustained coal utilization for power generation, while addressing possible long-term global climate concerns, it is imperative to capture and sequester the resulting CO2. The conventional technology for CO2 recovery from dilute flue gas after fuel combustion incurs substantial energy penalty… more
Abstract:DESCRIPTION (provided by applicant): It is reported that up to 40% of neonates undergoing cardiac surgery suffer a major thrombosis event. Pediatric patients who are at increased risk for thrombosis due to either congenital or acquired hypercoagulabilityrequire individualized anticoagulation… more
Abstract:Power systems are the core heartbeat of any advanced vehicle. Reliability and flexibility of these systems are therefore of the highest priority. This Phase 1 project proposes a highly efficient and modular isolated bidirectional DC converter for battery energy applications. GridBridge is… more
Abstract:The broader impact/commercial potential of this project is the development of a cornerstone for reliable electricity and a modernized grid able to evolve alongside emerging customer demands. Reliable electricity is key component of an industrialized market, critical for the information age, and an… more
Abstract:DESCRIPTION (provided by applicant): Atrial fibrillation remains the most commonly occurring cardiac arrhythmia. It is associated with a lower quality of life and a higher rate of morbidity and mortality. Cryotherapy and radiofrequency catheter ablations for the purpose of eliminating atrial… more
Abstract:Eno River Technologies and Duke University propose to develop Hybrid Boolean Network (HBN) technology for ultrafast physical random number generation. HBNs are circuits composed partly of unclocked logic elements that exhibit chaotic dynamics and clocked elements that provide readout and… more
Abstract:Project Summary/Abstract Liver cancer, primarily hepatocellular carcinoma (HCC), accounts for ~662,000 deaths each year and is the third leading cause of death from cancer worldwide. The age-adjusted incidence of HCC tripled between 1975 and 2005 in the US, and primary liver cancer mortality rates… more
Abstract:The use of non-native substrates for GaN- based devices leads to devices with high densities of defects stemming from misfit dislocation formation due to lattice mismatch and large values of wafer bow stemming from thermal mismatch. The latter is particularly problematic as one attempts to grow… more
Abstract:ABSTRACT The number of kidney transplant candidates on the waiting list continues to increase each year, while the number of kidney donations remains stagnant. The enduring donor shortage compels clinicians to use kidneys from marginal donors, referred toas expanded criteria donors (ECD). ECD… more
Abstract:DESCRIPTION (provided by applicant): Although non-pathogenic microbes that reside in our intestines generally provide us with numerous health and digestive benefits, a specific microfloral activity is also responsible for the severe and sometimes deadly gastrointestinal (GI) side effects of certain… more
Abstract:High Definition Ultrasound for Mammography Abstract We propose to develop High Definition Ultrasound (HD-US) based on a hemispherical synthetic aperture and backscattered sonic waves. This configuration will produce direct three-dimensional maps of ultrasound reflectivity of breast tissues, and… more
Abstract:DESCRIPTION (provided by applicant): Western life style has spurred the growth of numerous obesity related disorders including metabolic syndrome, type 2 diabetes and certain types of cancers to epidemic proportions. Maintaining cellular energy is a basicbiological need mediated in part through… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research (SBIR) Phase I project aims to develop a microfluidic-based nitric oxide (NO) sensor as an early sepsis risk assessment device. Sepsis causes significant strain on the U.S. healthcare system, consuming over 17 billion… more
Abstract:This Phase I project is relevant to the ultimate goals of this program announcement given the prevalence of the IED which often creates complex burn wounds on the face and skin that often form hypertrophic scars that often contract over time. Burn wound healing is a complex process that includes… more
Abstract:Improvements in body armor, availability of equipment, and decreased patient transport times have dramatically improved Soldiers"survival of combat injuries. Data suggests that future conflicts will require more aggressive wound management at the point of injury to deal with more complex… more
Abstract:DESCRIPTION (provided by applicant): This Phase IIB SBIR application is responsive to NHLBI RFA HL-13-016, NHLBI SBIR Phase IIB Bridge Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood and Sleep Disorders and Diseases (R44) . This RFA solicits work on basic,… more
Abstract:The project team is developing a prototype of a web-based intervention for pre-kindergarten and kindergarten students to prepare for the transition to grade school. The product will support students as they create stories using a step-by-step scripted interactive process. The stories will focus on… more
Abstract:Hall of Heroes will be a web-based game for fifth graders to engage with pedagogical agents (animated life-like characters) to solve tailored social problem solving tasks and build social skills to use in challenging situations. Instructional content will focus on six core Social Skill Units… more
Abstract:This project team will develop a web-based product to engage 11th and 12th grade high school students with HF-ASD in a self-paced online interactive course to learn about the transition to college, learn specific resilience strategies for coping with the transition to college, and to practice… more
Abstract:There is growing interest in computerized systems to increase accessibility of assessments for students with disabilities. Technology offers an ideal platform for implementing Universal Design (UD) principles for assessment to better accommodate student diversity and support broad student… more
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