Abstract:DESCRIPTION (provided by applicant): Cell Microsystems is a North Carolina-based start-up biotechnology company whose mission is to commercialize a novel, yet affordable, platform for the efficient isolation of viable, single cells or colonies from a mixedpopulation while the cell/colony remains… more
Abstract:DESCRIPTION (provided by applicant): With one out of every four youth in the United States currently living with a chronic illness, it is critically important to empower youth to take ownersip of their own healthcare. Research suggests that a key componentof a successful transition from pediatric… more
Abstract:Prototype Development and Refinement. We will develop a prototype with 2 games targeting coping skills for relaxation and substance refusal. The prototype will provide interactive instructional segments for each game along with game play to learn about andpractice each of these skill areas within an… more
Abstract:Abstract Retinal prosthetic devices currently under development are designed to bypass the non-functioning portion of the visual pathway (photoreceptor layer) in individuals suffering from diseases including retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Current devices… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project proposes to improve intrinsic crop yield through metabolic engineering of photosynthetic pathways. Genes encoding five rate-limiting enzymes for photosynthesis and starch synthesis will be co-expressed constitutively or in a… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project seeks to advance manufacturing processes in the dissimilar metal/impact welding industries via an aluminum/water reaction that chemically produces hydrogen energy. Ideally, the energy in the form of about 100 kpsi-200 kpsi, could be the… more
Abstract:Currently, toxicological risk assessment lacks direct estimation of the magnitude and variability of human responses to environmental toxicants. Specifically, there is very little data on the effects of low dose toxicants on human developmental processes,including cellular differentiation. That is… more
Abstract:DESCRIPTION (provided by applicant): In this application, we propose to conduct research to advance our patented technologies that identify early evidence of cardiovascular (CV) injury upon the receipt of cardiotoxic chemotherapy for breast cancer patients. For these patients, the prevalence of… more
Abstract:During covert operations, the U.S. Army may be required to breach a concrete structure using a controlled explosion. When choosing the most effective charge size and placement, it is vital to perform a rapid field assessment of the material and structural properties of the target structure. However,… more
Abstract:With the advent of very high strength concrete, such as that manufactured by LaFarge, calculations that have been used historically to determine the explosive content needed to breach concrete structures have been compromised. As a result of this and other mission critical issues, the Army has… more
Abstract:The goal of this application is to synthesize heparan sulfate (HS) library consisting of structurally homogeneous oligosaccharides, in response to a SBIR contract call from NCI- 321 Chemically Defined Glycan Libraries . Glycan Therapeutics is a company specializing in the synthesis of structurally… more
Abstract:Breast cancer is the most common cancer type among women. Approximately one in every eight women is diagnosed with breast cancer at some time in their life and 30% to 40% of the women who get breast cancer die. Early and accurate detection is viewed asthe best method to decrease breast cancer… more
Abstract:Technical abstract 13.1-005 Today there is no sub-sonic ammunition currently type classified for use in the calibers provided by any DoD Service. Although sub-sonic rounds exist for some calibers, these rounds are not cost effective and exhibit excessive deviations in velocity (affecting accuracy),… more
Abstract:DESCRIPTION (provided by applicant): Hypersecretion of mucus into the respiratory airways is a major contributing factor in several lung diseases, including chronic pulmonary disease (COPD), asthma, cystic fibrosis, allergic rhinitis, and bronchiectasis.Despite the obvious medical importance, there… more
Abstract:DESCRIPTION (provided by applicant): Revenue growth and market capitalization of pharmaceutical firms have plunged over the past 10 years. Why? An important factor is that the engine for growth in drug discovery has come to a standstill. Historic relianceon synthetic organic chemistry and more… more
Abstract:The objective of this proposal is to design, analyze, and implement scalable algorithms for analysis-driven construction of high-resolution 3D terrain models from BIG terrain data sets, and to build a software infrastructure for making analysis-prepared terrain models available to data consumers on… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project demonstrates a proof of concept for a solid state transformer (SST) that is commercially feasible and can ultimately meet electric utility requirements: highly efficient, cost-competitive, manufacturable within a specific market window,… more
Abstract:DESCRIPTION (provided by applicant): Type 2 diabetes (T2D) is a devastating disease that has undergone a striking increase in prevalence in the U.S. and worldwide. Although a number of different drugs exist to help manage this condition, unfortunately morethan 1/3 of affected individuals fail to… more
Abstract:DESCRIPTION (provided by applicant): There are approximately 12 million people suffering from autosomal dominant polycystic kidney disease (ADPKD) worldwide. ADPKD is a chronic condition with no effective drug therapies available; dialysis and transplantation are performed at costs of gt 2… more
Abstract:DESCRIPTION (provided by applicant): There is a need for an exposure instrument that is cost-effective and can directly measure the toxicity of the air in real time. This capability is needed to understand the negative impact on health that occurs in realworld exposures to multiple pollutants in… more
Abstract:DESCRIPTION: Organophosphate (OP) pesticides are highly toxic compounds used to control insect populations in a number of agricultural and landscaping applications. The widespread use of these toxic chemicals has generated serious environmental health risks. It is vital to sensitively and… more
Abstract:DESCRIPTION: Molecular simulations have been widely applied to determine the structures and thermodynamic properties of organic compounds, the conformational characteristics and reactivity of proteins and nucleic acids, and the ligand-protein bindings. Still, the scope of the applications has been… more
Abstract:DESCRIPTION (provided by APPLICANT): The critical need for parent involvement in early intevention is clear in federal regulations (Individuals with Disabilities Act, Part C) and is supported repeatedly in research by positive benefits for parents and forchildren developing a range of skills. Since… more
Abstract:DESCRIPTION (provided by applicant): Although strict adherence to antiretroviral therapy (ART) is required to achieve health benefits of treatment, there are no known interventions that have improved ART adherence among young Black men who have sex with men (YBMSM). Novel, sustainable interventions… more
Abstract:PROJECT ABSTRACT Glaucoma is a common neurodegenerative disease which is the 2nd leading cause of blindness in the United States. With the aging baby boomer population, these numbers will continue to increase exponentially over the next few decades. With glaucomatous progression, there is ultimately… more
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