Abstract:This proposed Phase I program focuses on the development of a novel solid electrolyte that is low cost and has the potential of yielding high conductivity for lithium ion.s These novel materials have stable crystal structures and are quite robust up to temperatures of 560 degrees celcius. Objectives… more
Abstract:NASA requires a safe, long-cycle-life lithium battery that is rechargeable, efficient and reliable for powering space electronics. A solid polymer electrolyte for lithium batteries will allow placement of the electrodes in close proximity, bipolar cell construction, retardation of undesirable… more
Abstract:2D real-time phased array ultrasound has become a dominant medical imaging modality due to low costs, high efficacy and the absence of ionizing radiation. The total worldwide market for diagnostic ultrasound is $2 billion annually. Real-time phased array volumetric scanning systems (often called "4D… more
Abstract:This Phase I program will investigate the potential for paraffinic phase change materials (PCMs) to provide a light, passive, and non-burdensome body undergarment theraal manageaent system for the USMC. Based on Biaterials and technologies developed under eight previous SBIE prograBis for NASA, USAF… more
Abstract:FIELD PROGRAMMABLE GATE ARRAYS (FPGAS) AND FIELD PROGRAMMABLE INTERCONNECT DEVICES (FPIDS) HAVE THE ABILITY TO INTEGRATE THOUSANDS OF LOGIC GATES ON A SMALL BOARD IN WHICH THE INTERCONNECTIONS CAN BE COMPLETELY REARRANGED WITHIN MILLISECONDS WITHOUT MANUAL EFFORT. USING FPGAS AND FPIDS, IT IS NOW… more
Abstract:This research develops, tests, and disseminates a curriculum-based program which is effectivein preventing the onset of substance use and abuse among adolescents. The program is delivered in theinitial year to middle or junior high school by trained specialists. Programmatic focus addressesmediating… more
Abstract:A TEST SYSTEM FOR RAPID SCREENING OF PATIENTS PRIOR TO INITIATION OF THROMBOLYTIC THERAPY WILL BE DEVELOPED. THIS SYSTEM WILL BE BASED ON A NOVEL DRY REAGENT ASSAY TECHNOLOGY WHICH RECENTLY HAS BEEN APPLIED SUCCESSFULLY TO PT AND ACTIVATED PTT TESTS. INTRODUCTION OF A RAPID CONVENIENT TEST OF… more
Abstract:USE OF NUCLEOSIDE PHOSPHATES AS ANTITUMOR AND ANTIVIRAL AGENTS HAS BEEN LIMITED BY THEIR INABILITY TO PENETRATE CELL MEMBRANES AS WELL AS THEIR HIGH SUSCEPTIBILITY TO ENZYMES SUCH AS PHOSPHATASES, NUCLEOTIDASES, ETC. MODIFICATION OF THE PHOSPHATE GROUP (BY REPLACING ONE OF THE NONBRIDGING OXYGENS… more
Abstract:NEUTRON CAPTURE THERAPY IS A VERY PROMISING THERAPY FOR CERTAIN TUMORS, SUCH AS GLIOMAS AND MELANOMAS. SEVERAL NUCLEI HAVE HIGH CROSS SECTIONS FOR THERMAL NEUTRONS, OF WHICH BORON-10 ((10)B) AND GADOLINIUM-157 ((157)GD) HAVE BEEN SHOWN TO BE VERY PROMISING. (10)B HAS A HIGH CROSS SECTION FOR THERMAL… more
Abstract:The main objective of the research is to develop a new class of topoisomerase II (Topo II) inhibitors as antineoplastic agents. In preliminary studies, heterocyclic amine-carboxyboranes have been shown to possess cytotoxic activity against a number of murine and human tumor tissue culture lines, e.… more
Abstract:We will design and synthesize novel nucleic acid base derivatives containing cyanoborane group attached to a pyridine-type nitrogen atom of the purine or the pyrimidine cycle. The cyanoboronated bases may be designed to be more membrane soluble than the respective 2'- deoxyribonucleosides of known… more
Abstract:A major problem with the use of nucleoside phosphates as antiviral and antitumor drugs has been their inability to penetrate cell membranes. Additionally, nucleoside phosphates are susceptible to phosphatases and nucleases, which reduce their in vivo life time. Replacement of the charged phosphate… more
Abstract:A new approach to signal detection and classification is applied to the problem of ASW and torpedo defense for shallow-water environments. The approach is particularly appropriate for applications where the statistics of the signal and the noise are unknown and highly variable. The primary goal is a… more
Abstract:There is an increasing need in many military systems to have solid state microwave devices with higher power capability, higher reliability, and higher operating temperatures. These devices would be important for airborne radar systems, electronic warfare and countermeasure systems, and airborne and… more
Abstract:Silicon carbide possesses a unique combination of properties, not available from other more common semiconductors, which allow it to operate in certain severe environments. These properties include a wide bandgap, a high melting point, high breakdown electric field, and high thermal conductivity, as… more
Abstract:BETA-SIC HAS BEEN KNOWN FOR MANY YEARS TO HAVE EXCELLENT THEORETICAL PROPERTIES FOR THE PRODUCTION OF HIGH POWER MICROWAVE DEVICES. THE COMBINATION OF ITS WIDE BANDGAP (2.2 EV @ 27 DEGREES CENTIGRADE), HIGH SATURATED ELECTRON DRIFT VELOCITY (2.5x10(7) CM/SEC), HIGH BREAKDOWN ELECTRIC FIELD (4x10(6)… more
Abstract:This program will demonstrate the applicability of the freeze crystallization (FC) process dirctly to U.S. Air Force environmental managers by, in phase I, (1) finding applications that are well served by this technology, (2) demonstrating the capabilities of the FC process by processing wastes in… more
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