Abstract:DESCRIPTION (provided by applicant): Invasive aspergillosis (IA) caused by the fungus Aspergillus fumigatus is the most frequent fungal cause of death in immunocompromised patients. The number of patients at risk for developing IA is steadily increasing due to advances in medicine. Early and… more
Abstract:DESCRIPTION (provided by applicant): This Phase I Small Business Innovation Research (SBIR) proposal seeks to develop an innovative, inexpensive, and reliable system, called the Tummy-Time Motivator (TTM), to motivate children to improve postural control.Postural control is the foundation for the… more
Abstract:DESCRIPTION (provided by applicant): The objective of this Phase I SBIR application is the proof-of-principle for an innovative and reliable subdermal electroencephalogram (EEG) monitor. The EEG is the most widely-used monitor of brain function. Over a fifth of the population suffers from brain… more
Abstract:DESCRIPTION (provided by applicant): The SCID is the 'gold standard' for all research-based mental health diagnoses in the United States and for CNS clinical trials worldwide. But, it has been expensive and cumbersome to administer. In Phase I and II of this project we successfully… more
Abstract:DESCRIPTION (provided by applicant): The human inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, affect over one million Americans and significant unmet medical needs still exist. Activation of NF??B transcription factors are central events in the initiation and… more
Abstract:Purpose: Students with high functioning autism spectrum disorders (HF-ASD) face unique challenges with social skills and social relationships, often experiencing heightened levels of social isolation and exclusion from social opportunities. Without intervention, these social difficulties can… more
Abstract:DESCRIPTION: In the medical device industry, silicone oil is a ubiquitous lubricant used in the manufacture, assembly of medical components, and also as the terminal lubricant for proper device operation. In prefilled syringes, problems arise when micro-droplets of silicone oil migrate into the… more
Abstract:The Vadum Multi-shot Robotic EOD Disrupter (MRED) system builds upon the known effectiveness and versatility of the 12-gauge SD-IED disrupter by adding systems to enable remote loading and firing of multiple shots from EOD robotic platforms. Multi-shot capability allows engagement of one or more… more
Abstract:Many currently deployed and in-development weapons and associated systems require copious amounts of RF (radio frequency) power at many different frequency ranges. Simply put, the problem of RF power generation gets more difficult with increasing power level, increasing frequency, increasing… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of the proposed study is to develop a monoclonal antibody that inhibits the progression of diabetic retinopathy. Insulin-like growth factor-I (IGF-I) has been implicated in both endothelial dysfunction as well as the proliferative phase of… more
Abstract:DESCRIPTION (provided by applicant): Diabetes and diabetes-related co-morbidities are at epidemic proportions and an enormous burden to our healthcare system. Although there has been significant progress in defining the causative factors and molecular mechanisms involved in both type 1 and type 2… more
Abstract:Purpose: To be qualified to teach their future students in math, preservice students need to gain specialized mathematics content and pedagogical knowledge. The purpose of this project is to develop a web-based game to strengthen preservice teachers' knowledge of mathematics and provide college… more
Abstract:We propose to develop an advanced navigation solution for public transportation passengers that will guide them from their origin to single or multiple destination points and across multiple modes of transportation. Passengers will simply need to enter their destination (and optionally a starting… more
Abstract:We propose development of a robust and reconfigurable distributed processing architecture, whose framework will support high availability and cooperative sharing of localization information, services, and processing capability across mobile wireless ad hoc networks nodes, including both human and… more
Abstract:This Phase 1 SBIR project aims to develop a frequency stabilized laser diode system suitable for application in optical metrology and in displacement measurement. The compact design of the semiconductor laser lends itself to many applications where a coherent light source is required, but space is… more
Abstract:Currently nuclear-based gauges are the most widely used equipment in the construction industry to measure moisture and density of pavement materials. Such measurements are very accurate, rapid, and non-destructive. Attempts to replace these nuclear methods by non-nuclear methods have shown strong… more
Abstract:The objective of proposed work is to demonstrate the feasibility of obtaining AlGaN films of any composition with dislocation densities below 1x106 cm-2 on native nitride substrates either by sustaining a pseudomorphic state or by reducing the number of threading dislocations by specific stress… more
Abstract:During the parachute deployment, cotton"buffer"fabrics are employed to prevent friction/abrasion damage to the nylon fabrics as they rub against each other at high speeds. Due to procurement difficulties and several technical deficiencies, the Army would like to replace the… more
Abstract:The use of automated robotic tooling is required in a number of space missions. It is possible to have better tool control if the robotic arm could report loads experienced by the tooling.ATI Industrial Automation proposes to develop and prove technologies to be used in a low weight, low outgassing… more
Abstract:DESCRIPTION (provided by applicant): The counterfeit drug business originated with lifestyle drugs, such as the erectile dysfunction drug. Now, however, counterfeits in almost any therapeutic category may be purchased by Americans through internet pharmacies. In fact, the Pharmaceutical Safety… more
Abstract:DESCRIPTION (provided by applicant): Cachexia-anorexia syndrome is a life-threatening aspect to many diseases, in particular many forms of cancer or therapies for cancer. The obvious symptoms of this disease include lack of appetite, and a loss of lean body mass disproportionate to the reduction in… more
Abstract:Innovation in perishable foodstuff track-and-trace is of critical importance to cost and time-sensitive customers such as the food industry where spoilage is of concern, safety and security are paramount, and counterfeit and bio-terrorism prevention are urgent priorities. The proposed research would… more
Abstract:This Phase I project develops and evaluates a mobile application for teaching elementary and middle school aged children with intellectual and developmental disabilities toilet training skills. A team of educational experts, technology experts, and parent of a child with autism collaborate on the… more
Abstract:The US is rapidly losing small-to-medium scale farmers. In the 10 years between 2007 and 1997, the U.S. lost over 11,000 farms and over 32 million acres of farmland. To save and attract new farmers to agriculture requires that farming be a profitable enterprise and that farmers have access to… more
Abstract:Fungi are microorganisms which are found throughout the world and are responsible for many natural processes including the decomposition of plant material and subsequent release of carbon, the preparation of food and beverages, as the source of pharmaceuticals, as well as the cause of a variety of… more
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