Abstract:DESCRIPTION (provided by applicant): The transplantation of heart grafts can dramatically provide a long and productive life to recipients with heart failure. Typical transplant survivals are more than 10 years. Because of an acute shortage of human donors, however, most do not receive their needed… more
Abstract:21CSI proposes, in Phase II, to deliver to the Navy a working prototype of the Sentinel Net system: A wireless, distributed asymmetric threat detection,reporting and situational awareness system for naval force protection. Through a specially designed system of networked client devices linked to a… more
Abstract:At the start of one new weapon development program, the projected cost of integration was more than the weapon development program itself. It resulted in killing the program. It's better now, thanks to the development and widespread use of a standard interconnection system. MIL-STD-1760 capable… more
Abstract:Keeping the Air Force assets flying is difficult enough at depot level where there are extensive facilities and expert help but in austere environment these advantages aren't present. A recent innovation, the Portable Maintenance Aid (PMA), is a new tool to the help the human through these… more
Abstract:The goal of a sensor manager is to cue the right sensor to perform the right service on the right target at the right time. This task essentially implies JDL Level 4 strategies and algorithms for control and action. In response to SBIR MDA04-023, 21st Century Systems, Inc. is pleased to propose… more
Abstract:There is a need to automate training, performance evaluations, and knowledge formation for personnel but especially expeditionary forces. The immediacy and high levels of performance required of expeditionary forces can push training tools and techniques to their limits. In response to SBIR AF04-058… more
Abstract:Traditional military command & control (C2) usually evokes images of operators in command posts centers. But what about the mounted or dismounted soldier trying to get from A to B without getting blown up? It's C2 as well, just a different scale. The digital battlefield provides an explosion of… more
Abstract:The capability to gather, analyze, and integrate vast amount of information from diverse data resources in various heterogeneous types and forms, and to distill from them the valuable intelligence leads or cohesions with respect to command and control decisions has become the top priority for U.S.… more
Abstract:The need for autonomous unmanned vehicles is becoming more evident. Unmanned surface vehicles (USVs) provide benefits ranging from manpower reduction and force multiplication, to performing missions too dangerous for manned platforms. One of the most critical challenges is the avoidance of obstacles… more
Abstract:Compared to fighting in the open field, military operations in urban terrain is the greater challenge. It's riskier and costlier in manpower, assets, and time. Warfighting in cities adds so many challenges that most commanders would prefer to bypass population centers. But that is not always… more
Abstract:There is strong requirement to field an interactive simulation environment that will model tactical and environmental entities in real time and enable goal-directed scenario generation. This capability is especially desirable in system integration, testing, certification, training and life-cycle… more
Abstract:When the call comes in to respond to a time critical target, there is little time for the watchstander to weigh the myriad factors that go into targeting decisions. We know where the target is now, but where will it be when the weapon system arrives to engage it? In order to plan for an effective… more
Abstract:Compared to fighting in the open field, military operations in urban terrain (i.e., man-made, built-up areas) is the greater challenge. It is riskier and costlier in manpower, resources, and time. The urban environment easily provides the in-place enemy with settings for ambush, places to hide,… more
Abstract:Submarine commanders are currently hamstrung in tactical mission planning due to the limited capability to assess operational options in response to changes in the threat, environment or assigned objectives. Current techniques to evaluate the assigned mission take little advantage of the recent… more
Abstract:DESCRIPTION (provided by applicant): This project produces a computer game title that integrates compelling computer gaming with constructive learning. The game is a first person action game located in and around cells in the human body. The player learns about cell biology while outmaneuvering and… more
Abstract:DESCRIPTION (provided by applicant): This project will investigate and develop methods for computer-based comparative visualization and interactive analysis of complex data generated by comprehensive two-dimensional gas chromatography (GCxGC). GCxGC is an emerging technology that provides an… more
Abstract:Micro- and nano-encapsulation (one nanometer = 0.000000001 meter) of food additives is an active R&D area. The release characteristics and protective properties of the encapsulant need to be tailored to specific industrial needs on a case-by-case basis. Nanotechnoly strategies as the one proposed in… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is a feasibility study to produce two-submicron inorganic powders via solvent-free processing routes. One of the materials is the anionic clay known as hydrotalcite, which is used as an antacid and a PVC additive. The other material is… more
Abstract:DESCRIPTION (provided by applicant): Polymerase Chain Reaction (PCR) amplification of DNA is the most reliable method for the rapid detection of pathogens. The overall rate of the PCR process is determined by performance of both the thermocycler and the companion biochemistry used to enzymatically… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop an improved thermocycler for high speed PCR (Polymerase Chain Reaction) using a systems engineering approach, thereby improving the throughput of PCR by two orders of magnitude.
The commercial application of this project… more
Abstract:DESCRIPTION (provided by applicant):
DNA vaccines and gene medicines are emerging as an important new class of pharmaceuticals that are derived from bacterial plasmids. For use in humans, plasmid DNA should be essentially free from bacterial genomic DNA and RNA, protein and endotoxin. The… more
Abstract:DESCRIPTION (provided by applicant): The primary objective of this Phase I STTR project is to develop an effective, peptide-based nicotine vaccine for use in humans capable of inducing a robust, nicotine-specific antibody (Ab) response with little or no inflammatory side effects. This will be… more
Abstract:DESCRIPTION (provided by applicant): In the clinical setting, molecular microbiologic detection methods have classically focused on a single microorganism or a small group of microorganisms. Broad range molecular detection of bacteria in clinical specimens is an approach that parallels a… more
Abstract:More than 1 million Americans have type I (insulin dependent) diabetes. Transplantation of human islets, with the appropriate immune suppression, can provide a long-term insulin free cure. However, there is a severe shortage of human islet donors available, sufficient for only about 1000 transplants… more
Abstract:DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) has emerged as a major public health problem. World wide, as many as 200 million people are infected. In the United States, an estimated 3.9 million are infected, with 2.7 million Americans chronically infected. The immune response of the… more
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