Abstract:Compared to fighting in the open field, military operations in urban terrain is the greater challenge. It's riskier and costlier in manpower, assets, and time. Warfighting in cities adds so many challenges that most commanders would prefer to bypass population centers. But that is not always… more
Abstract:There is strong requirement to field an interactive simulation environment that will model tactical and environmental entities in real time and enable goal-directed scenario generation. This capability is especially desirable in system integration, testing, certification, training and life-cycle… more
Abstract:When the call comes in to respond to a time critical target, there is little time for the watchstander to weigh the myriad factors that go into targeting decisions. We know where the target is now, but where will it be when the weapon system arrives to engage it? In order to plan for an effective… more
Abstract:Compared to fighting in the open field, military operations in urban terrain (i.e., man-made, built-up areas) is the greater challenge. It is riskier and costlier in manpower, resources, and time. The urban environment easily provides the in-place enemy with settings for ambush, places to hide,… more
Abstract:Submarine commanders are currently hamstrung in tactical mission planning due to the limited capability to assess operational options in response to changes in the threat, environment or assigned objectives. Current techniques to evaluate the assigned mission take little advantage of the recent… more
Abstract:DESCRIPTION (provided by applicant): This project produces a computer game title that integrates compelling computer gaming with constructive learning. The game is a first person action game located in and around cells in the human body. The player learns about cell biology while outmaneuvering and… more
Abstract:DESCRIPTION (provided by applicant): This project will investigate and develop methods for computer-based comparative visualization and interactive analysis of complex data generated by comprehensive two-dimensional gas chromatography (GCxGC). GCxGC is an emerging technology that provides an… more
Abstract:Micro- and nano-encapsulation (one nanometer = 0.000000001 meter) of food additives is an active R&D area. The release characteristics and protective properties of the encapsulant need to be tailored to specific industrial needs on a case-by-case basis. Nanotechnoly strategies as the one proposed in… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is a feasibility study to produce two-submicron inorganic powders via solvent-free processing routes. One of the materials is the anionic clay known as hydrotalcite, which is used as an antacid and a PVC additive. The other material is… more
Abstract:DESCRIPTION (provided by applicant): Polymerase Chain Reaction (PCR) amplification of DNA is the most reliable method for the rapid detection of pathogens. The overall rate of the PCR process is determined by performance of both the thermocycler and the companion biochemistry used to enzymatically… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop an improved thermocycler for high speed PCR (Polymerase Chain Reaction) using a systems engineering approach, thereby improving the throughput of PCR by two orders of magnitude.
The commercial application of this project… more
Abstract:DESCRIPTION (provided by applicant):
DNA vaccines and gene medicines are emerging as an important new class of pharmaceuticals that are derived from bacterial plasmids. For use in humans, plasmid DNA should be essentially free from bacterial genomic DNA and RNA, protein and endotoxin. The… more
Abstract:DESCRIPTION (provided by applicant): The primary objective of this Phase I STTR project is to develop an effective, peptide-based nicotine vaccine for use in humans capable of inducing a robust, nicotine-specific antibody (Ab) response with little or no inflammatory side effects. This will be… more
Abstract:DESCRIPTION (provided by applicant): In the clinical setting, molecular microbiologic detection methods have classically focused on a single microorganism or a small group of microorganisms. Broad range molecular detection of bacteria in clinical specimens is an approach that parallels a… more
Abstract:More than 1 million Americans have type I (insulin dependent) diabetes. Transplantation of human islets, with the appropriate immune suppression, can provide a long-term insulin free cure. However, there is a severe shortage of human islet donors available, sufficient for only about 1000 transplants… more
Abstract:DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) has emerged as a major public health problem. World wide, as many as 200 million people are infected. In the United States, an estimated 3.9 million are infected, with 2.7 million Americans chronically infected. The immune response of the… more
Abstract:As we progress towards the network-centric environment envisioned by JV2010 and JV2020, our dependency upon space assets to meet our force enhancement (C4, weather, navigation, intelligence, surveillance, etc.) requirements is expected to growexponentially. This trend is not only for our forces,… more
Abstract:There are major changes in today's business methods. Expensive and time consuming travel for gathering project personnel together will be replaced, in part, by network-centric technology. Management directives of large corporations are increasinglystipulating the use of a collaborative workspace… more
Abstract:Most of today's precision guided weapons use Global Positioning System (GPS) signals to gain improved accuracy. But, as Operation Iraqi Freedom recently showed, foreign militaries have equipment to locally jam GPS signals. Another effective method ofautonomous navigation is necessary to ensure… more
Abstract:72526S03-I Collaboration on experimental nuclear physics projects is international and requires hundreds of participants. Due to the sheer size and complexity of the experiments, a great deal of the experimental planning, equipment design, preparation, and assembly must be carried out prior to the… more
Abstract:Agents, Agent Architectures and Agent-based applications have become a phenomena in recent years with seemingly everyone jumping on the bandwagon. However, as with any truly revolutionary breakthrough technology, Agents have lacked standards and rulingbodies to govern the direction of the bandwagon… more
Abstract:As demonstrated with recent engagements, US forces will not go into combat alone. Multinational coalition forces will be the norm and our forces must flexibly adapt to the command and control (C2) environment with the newly formed team. Whether a neighboror long time ally with similar but… more
Abstract:It is a global extent of terrorist networks, opposed to large powers, attacking the U.S Navy abroad, U.S. Embassies, and now in our homeland. Traditional methods are based on defending from what has happened in the past:
Abstract:In response to SBIR solicitation OSD03-027, 21st Century Systems, Inc. (21CSI) is pleased to propose investigating and developing a software agent system organized in a hierarchically networked architecture that incorporates use of multiple existingsystems into a high-level information fusion system… more
Abstract:This Small Business Innovative Research Phase I project builds on a research program investigating the design of process-based software development tools and methodologies. The project will develop a next generation of this software that supports the creation, refinement, and adaptation of software… more
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