Abstract:We will characterize the pharmokinetics of a peptide GPIIb/IIIa receptor antagonist in a caninemodel. Our research has three specific aims. In the first aim, the applicant intends to fully characterizethe pharmokinetics of P246, a 12 residue GPIIb/IIIa receptor antagonist peptide, in a ac dog model… more
Abstract:As neutrophils are the first type of leukocyte to localize to a site of infection, small syntheticpeptides that bind with high affinity to cell-surface receptors that mediate chemotaxis of neutrophilsprovide a rational basis for the development of an infection specific radiopharmaceutical. The… more
Abstract:THE OBJECTIVE OF THE WORK IS TO DEVELOP EFFICIENT AND ACCURATE COMPUTATIONAL TECHNIQUES FOR THE SOLUTION OF MOVING FRONT PROBLEMS SUCH AS THOSE OCCURRING IN PHASE-CHANGE, POLLUTANT DISPERSAL, GROUNDWATER TRANSPORT, AND OTHERS. MIMD PARALLEL PROCESSING IS TO BE USED TO OBTAIN THE COMPUTATIONAL SPEED… more
Abstract:AMERICA IS FALLING BEHIND IN SCIENCE TEACHING. YOUNG STUDENTS' INTEREST IN SCIENCE MUST BE STIMULATED TO MAINTAIN THE INTELLECTUAL VIGOR AND ECONOMIC COMPETITIVENESS OF THE NATION. WHO HAS NOT BEEN FASCINATED BY A SCANNING ELECTRON MICROSCOPE (SEM) PICTURE OF A FLY, OR ANT, OR GRAIN OF POLLEN WITH… more
Abstract:The resolution gap between available chip (sub-micron) and off-chip (100 to 125 micron) will be closed by a new laminate interconnection technology. Semiconductor manufacturing techniques, either on wafer (NChip) or in thin film form (IBM and others), are used to bring line widths and thicknesses… more
Abstract:ANATOMIC AND PHYSIOLOGICAL DERANGEMENTS OF THE GASTROINTESTINAL TRACT CAN LEAD TO ABNORMAL OVERGROWTH OF THE SMALL INTESTINE. A QUANTITATIVE CULTURE OF AN ASPIRATE OF SMALL BOWEL FLUID IS USED TO DETECT BACTERIAL OVERGROWTH. THIS IS OFTEN NOT PERFORMED BECAUSE IT IS SO INCONVENIENT. THE NEED FOR A… more
Abstract:The introduction emphasizes the clinical need for an artificial system which can transporthemoglobin which has been oxygenated in the lung to tissues in the body. Thus, the quest for amodality which could transport, store, and release oxygen to the tissues when required. The transportform must also… more
Abstract:THE USE OF ANTIBODIES IN COMMERCIAL IN VITRO IMMUNODIAGNOSTIC KITS AND IN OTHER RESEARCH IMMUNOASSAYS PLACES A REQUIREMENT ON ANTIBODY PRODUCTION FACILITIES AND RESEARCHERS TO PRODUCE SUITABLE HIGH TITERED POLYCLONAL AND MONOCLONAL ANTIBODIES. ADJUVANTS ARE USED TO INCREASE THE ANTIGENICITY OF… more
Abstract:RECUPERATIVE HEAT EXCHANGERS ARE KEY COMPONENTS IN REFRIGERATION SYSTEMS USED TO COOL SUPERCONDUCTING DEVICES IN HIGH ENERGY PHYSICS RESEARCH. PRESENT PLATE-FIN HEAT EXCHANGERS HAVE EFFECTIVENESS OF AROUND 0.97 AND PRESSURE DROPS OF SEVERAL PERCENT OF THE STREAM PRESSURE. APPROXIMATELY HALF THE… more
Abstract:HELIUM COOLING IS ATTRACTIVE FOR HIGH HEAT FLUX COMPONENTS IN TOKAMAK FUSION REACTORS BECAUSE THERE ARE LARGE SAFETY ADVANTAGES COMPARED TO WATER COOLANT. HOWEVER, CURRENT TECHNOLOGY FOR HELIUM COOLING IS HAMPERED BY THE COMPLEXITY OF THE HOUSING REQUIRED TO PROVIDE HELIUM TO THE NORMAL FLOW HEAT… more
Abstract:J-T cryoccolers potentially offer the best solution for sensor cooling applications. Because of the high cooling capacity per unit mass flow, the heat exchangers and J-T cryocoolers can be significantly better than that of other mechanical coolers. Despite these benefits, closed-cycle J-T… more
Abstract:Wet etching for oxide thin films is superior to dry processes because it has extremely low contamination, eliminates water markes from the wafers, provides a high degree of process flexibility and control, has better cleanliness, and the equipment is compact. However, wet etching has had limited… more
Abstract:Current two-phase computer codes for modelling of spacecraft thermal management systems or experiments are inadequate in many respects. Their multiphase models are inaccurate, outmoded, or poorly implemented. They are difficult to use without extensive training, and computation times are measured in… more
Abstract:Present CFD software provides only crude or no estimates of uncertainty in the calculated results. To bring error analysis in CFD to the level of development achieved for experimental data requires a systematic application of error analysis principles. This project proposes to develop an error… more
Abstract:Our goal is a major advancement in the life cycle of rechargeable, solid-state lithium/polymer batteries -- a factor of ten improvement to 1000's of recharge cycles. We will achieve this goal by attacking various problems of degradation at the electrode/ electrolyte interfaces, a primary factor in… more
Abstract:In this program Creare will develop test data and design methods for confident design of efficient cooling systems for turbine disks in aircraft gas turbine engines. Cooling systems must prevent ingress of hot combustion gases into the cavity between the turbine disk and its stator when there is an… more
Abstract:SINGLE CRYSTAL SILICON WAFERS ARE ESSENTIAL FOR INTEGRATED CIRCUIT (IC) MANUFACTURING. RESEARCHERS ARE DEVELOPING A METHOD TO FABRICATE THESE WAFERS DIRECTLY IN SHEET FORM IN CONTRAST TO CYLINDRICAL BOULES CURRENTLY UTILIZED. THE TECHNIQUE REDUCES THE COMPLEXITY AND COST OF THE CRYSTAL GROWTH… more
Abstract:The cost of processing erroneous or incomplete medical care claims, or of non-reimbursed services due to incorrect, unknown or incomplete insurance information, represents a considerable out-of pocket expense for every health care provider. The proposed project will develop a system for providing… more
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