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Displaying 3426 – 3450 of 3912 Awards
Company: Rhomed, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: A NEW METHOD OF DIRECT LABELING OF ANTIBODIES WITH TECHNETIUM-99M (TC-99M) WILL BE DEVELOPED AND EVALUATED. INTHIS METHOD, CALLED THE REGULATED REDUCTION METHOD, ONE CHEMICAL MEANS IS USED TO BREAK THE DISULFIDE BOND IN THE PROTEIN, AND A SEPARATE CHEMICAL MEANS IS USED TO REDUCE THE SODIUM… more
Company: Rhomed, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: THE OBJECTIVE OF THE STUDY IS TO DEVELOP A PAN-T-LYMPHOCYTE 99MTC-RADIOTRACER WHICH CAN BE USED TO STUDY TRAFFICKING OF STIMULATED LYMPHOCYTES AND AS A DIAGNOSTIC RADIOPHARMACEUTICAL FOR CHRONIC INFECTIONS SUCH AS OSTEOMYELITIS AND FOR GRANULOMATOUS DISEASES. THE PLANT-DERIVED ISOLECTIN,… more
Company: Sign Assessment, Inc Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: THE LONG-TERM GOAL OF THE PROJECT IS TO PRODUCE MARKETABLE, RESEARCH-BASED CHECKLIST FOR ASSESSING AND MONITORING THE SIGNED LANGUAGE DEVELOPMENT OF DEAF CHILDREN. TYPICALLY, CHILDREN WITH SUBSTANTIAL HEARING IMPAIRMENTS EXPERIENCE DELAYS IN ACQUIRING ENGLISH, BUT ACCESS TO A SIGNED LANGUAGE MAY… more
Company: Silhouette Technology, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: N/A
Company: Sonokinetics, Inc Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: IT IS POSTULATED THAT INTENSE (> 3 W/MM2) ACOUSTIC VIBRATION CAN BE CONVEYED WITH SUFFICIENT INTENSITY THROUGH A FLEXIBLE CONDUIT TO INTRAVASCULARLY EXCAVATE ATHEROSCLEROTIC PLAQUE. THE SYSTEM TO BE EVALUATED CONSISTS OF: (1) AN ACOUSTIC TRANSDUCTION CAVITY CONTAINING A MAGNETOSTRICTIVE PISTON… more
Company: Synaptic Pharmaceutical Corp. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: MOLECULAR CLONING AND HETEROLOGOUS EXPRESSION OF NEUROTRANSMITTER RECEPTOR GENES PROVIDE A MEANS TO STUDY THESE SITES OF DRUG ACTION FREE FROM THE COMPLEXITIES OF INTACT NEURAL TISSUE. THESE HETEROLOGOUS EXPRESSION SYSTEMSCAN THEN BE USED AS ASSAY SYSTEMS IN THE DEVELOPMENT OF NEW THERAPEUTIC AGENTS… more
Company: Synaptic Pharmaceutical Corp. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: THE SEROTONIN 5-HT1P RECEPTOR HAS BEEN EXTENSIVELY CHARACTERIZED IN THE ENTERIC NERVOUS SYSTEM WHERE IT FUNCTIONS IN THE REGULATION OF GASTROINTESTINAL MOTILITY. IN ADDITION, 5-HT1P-LIKE BINDING SITES HAVE BEEN DISCOVERED IN THE PERICARDIUM AND ENDOCARDIUM OF THE HEART, THE INNERVATION OF THE SKIN,… more
Company: Synaptic Pharmaceutical Corp. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: DOPAMINERGIC NEUROTRANSMISSION PLAYS A SIGNIFICANT ROLE IN PSYCHIATRIC AND EXTRAPYRAMIDAL DISORDERS, ENDOCRINE FUNCTION, AND VASODILATION. TO BETTER UNDERSTAND THE DOPAMINE D1 RECEPTOR AS A POTENTIAL SITE FOR DRUG DEVELOPMENT, IT IS PLANNED TO IDENTIFY AND CHARACTERIZE THE RECEPTOR GENE BY… more
Company: Synaptic Pharmaceutical Corp. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: OPIATE RECEPTORS, WHICH ARE IMPORTANT PHARMACOLOGICAL TARGETS FOR ANALGESIA AND FOR THE CONTROL OF DRUG ADDICTION,HAVE NOT BEEN CLONED AND THEIR AMINO ACID SEQUENCES ARE UNKNOWN. RECENT WORK INDICATES THAT SEVERAL OPIATE RECEPTORSUBTYPES ARE COUPLED TO G PROTEIN SECOND MESSENGER SYSTEMS. THEREFORE,… more
Company: Technical Imaging Services In Agency/Program/Year/Phase: DOD / SBIR / 1991 / 2
Abstract: OPTICAL ARCHITECTURES ARE NEEDED FOR REPRESENTING AND MANIPULATING THREE-DIMENSIONAL DATA OBJECTS IN A DATABASE ENVIRONMENT. A CLASS OF ARCHITECTURES BASED ON ARRAYS OF OPTICAL LOGIC DEVICES INTERCONNECTED IN FREE SPACE WILL BE STUDIED WITH THE EXPECTATION THAT THESE SYSTEMS WILL BE COMMERCIALLY… more
Company: Technical Imaging Services In Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: GENERAL PURPOSE COMPUTERS USED IN THE UNITED STATES AND OTHER COUNTRIES TYPICALLY ACHIEVE LOWER PERFORMANCE THAN CAN BE ACHIEVED WITH SPECIAL PURPOSE COMPUTERS FOR A GIVEN APPLICATION. THIS PHASE I PROPOSAL ADDRESSES A RELATIVELY UNEXPLORED CAPABILITY THAT HAS EMERGED IN OPTICAL COMPUTING, WHICH IS… more
Company: Unixpros, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: TESTING CONSUMES 30 TO 40% OF THE TOTAL DEVELOPMENT RESOURCES AND ABOUT THE SAME PERCENTAGE OF THE TOTAL DEVELOPMENT TIME IN MANY SOFTWARE SYSTEMS. IT IS VERY LABOR INTENSIVE AND EXPENSIVE; IT ACCOUNTS FOR APPROXIMATELY 50% OF THE COST OF A SOFTWARE SYSTEM. EXISTING ADA/FORTRAN PROGRAMS ARE COMPLEX,… more
Company: Unixpros, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: ACHIEVING HIGH PERFORMANCE AND MEETING REAL-TIME REQUIREMENTS ARE AREAS OF MAJOR CONCERN IN IMPLEMENTING REAL-TIME SYSTEMS IN ADA ON TARGETS RUNNING UNIX OPERATING SYSTEM. STANDARD UNIX LACKS REAL-TIME FEATURES THAT CAN ENABLE AN ADA RUNTIME SYSTEM TO BE DESIGNED SO AS TO ACHIEVE HIGH PERFORMANCE… more
Company: Vuln/eval Associates Agency/Program/Year/Phase: DOD / SBIR / 1991 / 2
Abstract: THE GOAL OF THIS PROGRAM IS TO DEVISE A METHODOLOGY FOR THE EVALUATION OF THE EW VULNERABILITY OF COMPLEX COMMUNICATION SYSTEMS IMBEDDED IN A NETWORK. IN ORDER TO DEVELOP THIS METHODOLOGY THE PARAMETERS OF THE COMMUNICATION SYSTEM MUST BE IDENTIFIED AND DEFINED, THE INTERRELATIONSHIPS AMONG THESE… more
Company: Equimax Communications Corpora Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: DIRECT-SEQUENCE SPREAD-SPECTRUM MULTIPLE-ACCESS (DS/SSMA) IS THE TECHNOLOGY OF CHOICE IN A WIDE VARIETY OF MILITARY RADIO NETWORKS WHERE MULTIPLE-ACCESS CAPABILITIES, ANTI-JAMMING, LOW PROBABILITY OF INTERCEPT, AND DYNAMIC TOPOLOGIES ARE IMPORTANT. THE PRINCIPAL SHORTCOMING OF OPERATIONAL RADIO… more
Company: MMTC, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: WE WILL DESIGN, ASSEMBLE, AND DEMONSTRATE IMPROVED EQUIPMENT FOR ADJUVANT THERMOTHERAPY OF CHOROIDAL MELANOMA. A SINGLE-FREQUENCY GENERATOR WITH INTEGRAL TELETHERMOMETER AND A SUITABLE IBM-COMPATIBLE COMPUTER INTERFACE WILL BE AUTOMATICALLY CONTROLLED TO PROVIDE A PRE-DETERMINED TEMPERATURE AT A… more
Company: Crystal Associates Inc Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: THE TECHNICAL OBJECTIVES OF THIS PROGRAM ARE TO ESTABLISH THE SYNTHESIS AND CRYSTAL GROWTH PARAMETERS REQUIRED TO PRODUCE TMAL3(BO3)4. THE CRYSTALS WILL THEN BE EVALUATED IN TERMS OF STANDARD SPECTROSCOPIC MEASUREMENTS FOR LASER APPLICATIONS. IN PARTICULAR, LINE WIDTHS, LINE STRENGTHS AND… more
Company: Aerochem Research Agency/Program/Year/Phase: DOD / SBIR / 1990 / 2
Abstract: A NEW PROCESS IS PROPOSED TO SYNTHESIZE PURE SPHERICAL BORONPOWDERS COATED WITH EITHER TITANIUM OR ZIRCONIUM FOR USE IN ENERGETIC PROPELLANTS AND EXPLOSIVES. THE PROCESS IS BASED ON A PROCESS PREVIOUSLY DEVELOPED BY AERO-CHEM TO PRODUCE PHOTOVOLTAIC SILICON. IT INVOLVES THE REACTION OF VAPOR PHASE… more
Company: Aerochem Research Agency/Program/Year/Phase: NASA / SBIR / 1990 / 1
Abstract: N/A
Company: Aerochem Research Agency/Program/Year/Phase: DOD / SBIR / 1990 / 1
Abstract: N/A
Company: Ail Research, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1990 / 1
Abstract: A HIGH-EFFICIENCY ATMOSPHERIC MOISTURE COLLECTION SYSTEM (AMCS) IS PROPOSED THAT USES A LIQUID DESICCANT TO EXTRACT WATER VAPOR FROM THE AIR. A STREAM OF POTABLE WATER IS RECOVERED FROM THE DESICCANT IN A SIMPLE BOILER. THE EFFICIENCY OF THE AMCS IS GREATLY IMPROVED BY USING AN ENGINE-DRIVEN… more
Company: AMT, INC. Agency/Program/Year/Phase: HHS / SBIR / 1990 / 1
Abstract: THE GOAL OF THIS PHASE I RESEARCH IS TO DESIGN, SYNTHESIZE, DEVELOP, AND EVALUATE THE IN VITRO EFFICACY OF A NEW CLASS OF POLYMERIC "TARGETED" PRODRUGS OF AZT. THE OVERALL OBJECTIVE OF THIS PROGRAM IS TO CREATE NEW ANTI-AIDS PRODRUGS THAT WILL POSSESS MARKEDLY ENHANCED ANTIVIRAL ACTIVITY, LOW… more
Company: AMT, INC. Agency/Program/Year/Phase: HHS / SBIR / 1990 / 1
Abstract: THE OVERALL OBJECTIVE IS TO PROVIDE A NEW DRUG DELIVERY SYSTEM AND TO ENHANCE THE SOLUBILITY OF EXISTING COMPOUNDS THAT EXHIBIT EXCELLENT ANTITUMOR PROPERTIES BUT ARE INSOLUBLE IN WATER. AQUEOUS SOLUBILITY IS ESSENTIAL FOR I.V. ADMINISTRATION OF ANTITUMOR DRUGS. PHASE I RESEARCH WILL SOLUBILIZE… more
Displaying 3426 – 3450 of 3912 Awards
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