Abstract:This Small Business Innovation Research Phase I project will advance the development of a new pulmonary testing instrument. The innovative device utilizes a strain gauge to measure pulmonary airflow, an indicator critical in monitoring the health of asthma and chronic obstructive pulmonary disease… more
Abstract:This Small Business Innovation Research Phase I project aims to develop an indoor real-time locating system to provide a better wireless computer mouse and to enable new 3D human-machine interface. The conventional optical mouse provides only 2D tracking, and requires battery and a non-reflective… more
Abstract:Cavitation and particle erosion in hydraulic turbines present unwanted consequences such as flow instabilities, excessive vibrations, damage to material surfaces, degradation of equipment performance, and inefficient energy generation. These problems are becoming more critical because the propensity… more
Abstract:The projected population growth and limited availability of fresh water sources have forced utility companies and industries to consider the use of alternate water for non-potable application, such as industrial cooling. While in excess of 100 billion gallons per day of water is used for cooling… more
Abstract:The increase in the ability of a wave energy converter (WEC) to capture energy from waves is critical to ensuring the viability and cost effectiveness of wave energy power devices. WECs absorb wave power by applying a back force to oppose the forces that waves exert on the system. The back force is… more
Abstract:Problem Statement: The worldwide manufacture and use of Portland cement for use in concrete accounts for roughly 5% of global CO2 emissions. A common practice in the production of Portland cement concrete (PCC) to reduce CO2 emissions levels is the partial substitution of cement with supplementary… more
Abstract:The David Ross Group will develop an innovative, miniaturized low-cost undersea transponder for data transmission over long haul underwater cable systems where the signal is generated from an undersea node and integrated with an undersea transmission system while minimizing the use and number of… more
Abstract:ABSTRACT: Linearizer Technology-GOV with L-3 Communications EDD proposes to produce a 100W power amplifier covering the 81 to 86 GHz band with the goal of a linear output power of 50W at a power efficiency of 20%,>30% PAE with additional TWT development. The HPA"s linear power is based on… more
Abstract:ABSTRACT: There has been a strong worldwide interest in the development of technologies that would enable hardware in the loop (HWIL) stimulation of imaging sensors. Presently, a majority of the image projection systems are based on micro-resistor arrays, deformable mirror devices, spatial light… more
Abstract:DESCRIPTION (provided by applicant): Type 2 Diabetes (T2D) is an inflammatory disease affecting 26 million people in the US (11%) and is predicted to affect more than 30% of adults in the US by 2050. The economic cost of T2D is over 200 billion a year. People with T2D suffer from hyperglycemia due… more
Abstract:DESCRIPTION (provided by applicant): The cysteinyl leukotrienes are primarily endogenous mediators of inflammation and play an integral role in the pathophysiology of asthma. Activation of leukotriene receptor has numerous effects in the lungs, including increased bronchial hyper responsiveness,… more
Abstract:DESCRIPTION: Recent phase II clinical studies demonstrate that an antibody targeting proportion convertase subtilisin/kexin type 9 (PCSK9)-a target for the treatment of hypercholesterolemia and coronary heart disease-successfully and safely decreases amounts of low-density lipoprotein-cholesterol… more
Abstract:DESCRIPTION (provided by applicant): We plan to develop novel tools for assessing GPCR ligands modulating G-protein-dependent and ?-arrestin- dependent ERK signaling pathways. Many GPCRs display a phenomenon in which different ligands can differentially activate different signaling pathways via the… more
Abstract:Develop an inexpensive, easy to use, aerosolized delivery system of a combination of anti-tubercular drugs that could be used for the treatment of multi-drug resistant tuberculosis (MDR TB ). PUBLIC HEALTH RELEVANCE
Abstract:i) The Phase 1 objectives are to develop and validate prototype components that may be readily integrated to create an instrument designed to meet the specifications defined by the NCATS Contract RFP. ii) B1-Microtiter plates commonly used for high throughput screening include 96 well (8x12), 384… more
Abstract:DESCRIPTION (provided by applicant): SBIR 1R43AR060019 Phase II application: Protein Therapeutics for Muscular Dystrophy Principal Investigator: Takizawa, Norio Project Summary: This application requests for a Phase II project for our initial SBIR grant addressing the use of a novel… more
Abstract:Boron carbide (B4C) ceramic is one of the hardest materials available and, in the form of a fiber composite, it is expected to improve ballistic performance of personal armor and armored vehicles. Due to the nature of its covalent bond, it is very difficult to manufacture full density boron carbide.… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to develop a novel quantitative particle agglutination technology for improving the performance of assays for detection of allo-antibodies to red blood cell antigens. Theconventional hemagglutination blood typing… more
Abstract:Junior infantry need usable tools and methods for collecting and interpreting significant information about the local economic environment through observation and questioning, and for developing daily tactical courses of action based on those interpretations. Altusys will lead a multidisciplinary… more
Abstract:In responding to the Army SBIR solicitation A10-045, Aria Microwave Systems, Inc. (AMS) has proposed to develop a high power, lightweight, compact, scalable SSD based DEW system with 60%-90% RF to DC efficiency. The proposed scheme utilizes the AMS proprietary active cavity amplifier (ACA)… more
Abstract:DESCRIPTION (provided by applicant): Dehydration is a frequent cause of morbidity and mortality in the elderly. Identifying at risk individuals and maintaining adequate fluid balance is an essential component of health care in the aging population. Currently, there is no effective tool available… more
Abstract:Among thermal control methods, variable-emittance materials remain the most promising for addressing deficiencies of current systems (mechanical louvers, loop heat pipes, MEMS, electrostatics, phase change materials, others), especially, e.g., for missions in extreme light/dark environments,… more
Abstract:ABSTRACT: Advanced Li battery technology remains beset with performance deficiencies at low/high temperatures/extreme environments (high vacuum, radiation, vibration/shock), primarily from poor conductivity/mobility in organic electrolytes used under such conditions. In this respect, electrolytes… more
Abstract:A new, very inexpensive, lightweight (25 mg/cm^2), low power (micro-W/cm^2), electrochemical voltammetric sensor technology for CW agents, based on unique conducting polymer microporous membranes and ionic liquid electrolytes with very wide operating temperature, is offered. Voltammetric sensing… more
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