Abstract:Aberrant functioning of proteins within stress response pathways (e.g. p53, NF-B, heat shock response) are prominent features in many cancer types. Such alterations have been associated with poor response of tumors to conventional antitumor treatments. This is true for such cancers as non-small cell… more
Abstract:This proposal addresses the need for innovative test packaging to permit testing of new focal plane arrays, read-out integrated circuit designs and related components in a mission relevant environment. We address the middle stage development gap that exists between FPA prototype and sensor system… more
Abstract:Conventional coagulation tests use an isolated portion of the blood coagulation cycle to assess blood function by activating pathways of the cycle via chemical additives. Thromboelastography (TEG) is an effective tool for monitoring the entire coagulation cycle as a whole from a physical standpoint… more
Abstract:A detail computational model is important in the construction and optimization of a slow-light gyroscope. Such a model needs to take into account many physical conditions such as Doppler broadening and cavity boundary conditions. As a result, the computational cost and resources for a full model can… more
Abstract:The challenges of the next century of aviation will require innovative and revolutionary concepts to meet air transportation demands. One NASA vision for future transport-sized aircraft includes the blended-wing-body (BWB) platform with embedded, distributed propulsion as a means for increased… more
Abstract:Spacesuit glove pressure garments have been a design challenge for NASA since the inception of spacesuits. The human hand demands a complex range of motions, a close fit, an ease of movement, and a lack of bulk that is at odds with the engineering and durability requirements of an inflated safety… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is to develop a self-powered Microelectromechanical Systems (MEMS) piezoelectric wireless sensor platform architecture based on a Micro-Vibrational-Energy-Harvester (uVEH) that can be monolithically integrated with MEMS sensors. Current… more
Abstract:This Small Business Innovation Research Phase I project concentrates on the opportunities that exist in organizing consumers' opinions, unstructured information that makes up a significant portion of Internet content. Organizing this information will lead to efficiency gains in current markets… more
Abstract:This Small Business Innovation Research Phase I project investigates the development of an inexpensive ultra-compact optical spectrometer. The photonic crystal spectrometer uses the leaky modes of photonic crystals patterned on a multimode waveguide to selectively extract wavelength specific light… more
Abstract:The proposed innovation is a compact infrared photonic crystal spectrometer. The photonic crystal spectrometer utilizes the leaky modes of photonic crystals patterned on a multimode waveguide to selectively extract wavelength specific light to a 2D detector array (e.g. an imager). The pattern… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project addresses development of an efficient integrated multi-agent system for distributed environment mapping, monitoring, and anomaly detection for water surface mobile aquatic robots dispersed in a riverine, lake, estuary, or coastal… more
Abstract:The objective of this Phase I SBIR project is to develop an Autonomous Underwater Vehicle (AUV) with integrated sensing system for efficient and accurate spatial sampling for robust navigation, bathymetric SLAM, and current surveys in riverine environments. The proposed AUV system utilizes… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop PhysBUG, a hand held hardware module that contains a physics workbook on the device, called BUGbook, that will evolve to a toolset that includes a combination of instruction, measurement, inquiry, and design. PhysBUG… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will establish an aquaculture facility to breed and maintain laboratory reared populations of cephalopods. Marine Biomedical Technologies (MBT) is uniquely prepared to overcome the obstacles involved in successfully raising large… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to construct the first in a series of science collaborative multiplatform learning games called Martha Madison?s Marvelous Machines. This game will be designed to engage a target audience of middle school girls in virtual… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to generate an improved HIV-1 vaccine immunogen geared toward antibody responses by engineering an HIV-1 Envelope glycoprotein (Env) trimeric complex that is stabilized in its functionally relevant conformation by application of… more
Abstract:DESCRIPTION (provided by applicant): The Gastrointestinal (GI) Syndrome is a primary complication of cancer treatments, associated with delivery of therapeutic doses of chemotherapy and radiation, and also constitutes a potentially lethal result of accidental ionizing radiation (IR) exposure. The… more
Abstract:DESCRIPTION (provided by applicant): There are high unmet medical needs in the limited biologic therapeutics for 1.0% of adults with rheumatoid arthritis [RA] associated with staggering 39.2 billion annual US health care and societal costs. These are dueto inadequate efficacy; patient's… more
Abstract:DESCRIPTION (provided by applicant): The objective of this Phase I SBIR proposal is to provide improved therapies for the treatment of periodontal disease. Periodontal Disease is a chronic infectious disease of the oral cavity that effects about 35 % of the adult population in the United States, or… more
Abstract:DESCRIPTION (provided by applicant): We propose to develop rapid-scanning optical-resolution photoacoustic microscopy (OR-PAM), which is capable of label- free imaging of non-fluorescent optical absorbers. Optical absorption contrast is highly desirable for microvascular imaging and … more
Abstract:DESCRIPTION (provided by applicant): One potential therapeutic approach to treat sickle cell disease (SCD) involves the administration of aryl aldehyde-containing small molecules that form Schiff base adducts with hemoglobin (HbS) and prevent sickling. Theutility of this approach is inherently… more
Abstract:DESCRIPTION (provided by applicant): Schizophrenia is a chronic and debilitating brain disorder that affects about 1.1 percent of the US population age 18 and older in a given year and account for 5% of all disease burden in the US. It is estimated that 20% to 60% of patients have… more
Abstract:DESCRIPTION (provided by applicant): The objective of this research is to develop a tissue magnetic susceptibility property analyzer for processing gradient echo (GRE) MRI data. GRE MRI has been routinely used in clinical practice. A major aspect of its image contrast is based on its unique… more
Abstract:DESCRIPTION (provided by applicant): There has been a dramatic growth in the purchase and use of interactive whiteboards (IWBs) for K-12 classrooms. These products promote the use of engaging instruction that can address various styles of learning and havedemonstrated results in terms of enhanced… more
Abstract:DESCRIPTION (provided by applicant): Ai Cure Technologies LLC, was established in 2009 to develop webcam software solutions for mobile devices and other computing platforms that automate and reduce the cost of monitoring patient behavior and medication adherence. Poor medication adherence is one of… more
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