Abstract:DESCRIPTION: Renal transplantation is the most effective and cost-efficient form of renal replacement therapy for a burgeoning population that presents with end-stage renal disease. Although organ donation has become a national priority, the gap between the number of patients awaiting a kidney vs.… more
Abstract:DESCRIPTION (provided by applicant): Liver fibrosis, a disease affecting tens of millions of people worldwide, is the liver scarring response to chronic injury from excessive alcohol use, virus infection (hepatitis B and C), iron overload or extrahepatic obstructions and can progress to liver… more
Abstract:DESCRIPTION (provided by applicant): Alcoholic and non-alcoholic liver fibrosis remains an unsolved challenge for the hepatologist as it can lead to cirrhosis and end-stage liver disease, a life-threatening condition that necessitates liver transplantation. Current therapeutic strategies for the… more
Abstract:To address the need of the Army in a deterministic method for generating a dome with precise location of a buried grid, Applied Science Innovations proposes development of the Electro-Optical Depth Sensor (EODS), a new tool for non-contact depth measurement. The non-contact measurement from either… more
Abstract:To meet the need of the Navy in fabrication and measurement of conformal windows, such as toroidal made of spinel, to precise optical tolerances, Applied Science Innovations (ASI) proposes Phase II development of the Interferometric Tomography metrology system, building directly on the Phase I… more
Abstract:Current processes for transporting electronic files across security domains limit the allowable file formats to a small, well-recognized set. The introduction of physical media into or out of secure areas requires manual analyses and multiple diagnostic scans. With the pace of innovation in… more
Abstract:The proposed research focuses on the development of a new adaptive control methodology for active control of wing aerodynamic shape to effect distributed aerodynamic forces and moments for maneuvering and stabilization of flexible airframes without moving control surfaces. The new aero-effected… more
Abstract:Computing systems built on identical foundations (hardware, operating systems, etc.) will be vulnerable to the same attacks. To avoid widespread failures, techniques have been sought for introducing"synthetic diversity"into systems. The best studied are low level randomization… more
Abstract:ABSTRACT: Despite existing security efforts, DoD networks are susceptible to attack and compromise. For critical missions, it is necessary to"fight through"cyber attacks in order to achieve mission objectives. Such a"survivable"network would be capable of carrying on (in a… more
Abstract:ABSTRACT: Analysts must determine the proper response to an alert produced by an anomaly detection system. Currently, analysts must manually generate queries to other intelligence sources and then search by hand through the results to find evidence relevant to the alert. This is a slow and… more
Abstract:Botnets and other large-scale malicious behaviors present a pervasive and evolving threat to cyber security. Stealth botnets and distributed, stealthy cyber attacks present a particular challenge to cyber defense because their malicious behavior is difficult to detect. State-of-the-art and… more
Abstract:Universal Serial Bus (USB) devices such as thumb drives are commonly used to share information between computers. These innocuous-looking devices, however convenient, also serve as vectors for attacks. For example, unsuspecting military personnel can easily carry malicious software or hardware into… more
Abstract:a novel family of proximity switchs is proposed based on EM technology field perturbation.This technology enables the proximity switch to be low cost, light weight, highly accurate and meets all MIL_PRF_24711B requirements. The prposed switch can be used in new NAVY vessel design as well as retrofit… more
Abstract:DESCRIPTION (provided by applicant): Caused by Borrelia burgdorferi, Lyme Disease (LD) can affect the skin, heart, joints or nervous system leading to an array of symptoms that overlap with those of other illnesses. LD is the most common vector-borne infectious disease in the United States and… more
Abstract:ABSTRACT: In today"s war environment, leaders are generating more Requests for Information than ever to support the fight and the MTI sensors providing beneficial information to service these requests are growing in number and capability. Thus analysts must have utilities at their disposal… more
Abstract:In current tracking and data fusion applications, each mission, each scenario, each different configuration of sensors and measurement types typically results in a different tracking algorithm or configuration that produces the optimal performance results. However, the ability to quickly and easily… more
Abstract:Black River Systems, with notable GMTI radar/tracking experience coupled with our recent work to characterize and model dismounts, proposes an innovative algorithmic approach to discriminate between humans and wildlife based on motion analysis. We developed the BRAT Tracker used on a daily basis to… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to take FallScape multimedia fall prevention (FP) methodologies from a locally-hosted user-centric set of resources to a web-based architecture in order to facilitate the translation of fallprevention strategies into a variety of… more
Abstract:ABSTRACT: The design and development of Micro Aerial Vehicles (MAV) has moved from scaled down conventional aircraft configurations to biologically-inspired concepts structurally mimicking birds and insects. As this research has expanded, traditional aerodynamic analysis where rigid structures are… more
Abstract:DESCRIPTION (provided by applicant): Tissue digestion and cell extraction is a core element of a variety of bioprocessing methods ranging from isolation of the rare cancer stem cell for basic research to the purification of human islets or adipose-derivedmesenchymal stem cells for transplant. While… more
Abstract:DESCRIPTION (provided by applicant): The cultured cell has emerged as a critical link in the translation of research in the various fields of biotechnology and biomedicine. An unprecedented increase in the demand for cultured cell products is now drivenby the growth in biopharmaceuticals, cancer… more
Abstract:DESCRIPTION (provided by applicant): The results of early clinical trials using stem cells clearly offer the promise of a new path to addressing a variety of medical problems that range from creating engineered tissues for autologous grafts to repairing a variety of organs. Mesenchymal stem… more
Abstract:DESCRIPTION (provided by applicant): Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis with an estimated two billion people currently infected worldwide and over nine million new cases detected annually worldwide. This is the largest killer of patients with HIV/AIDS.… more
Abstract:Purpose: Prior research has shown that students who are considered to be gifted generally have high levels of academic performance, motivation, creativity, critical thinking skills, and positive self-concepts. Perhaps because the general perception is that gifted students will flourish under any… more
Abstract:DESCRIPTION (provided by applicant): The cardiopulmonary bypass circuit (i.e. the Heart Lung Machine) that supports patients undergoing cardiac surgery, is constantly being refined. Both the venous reservoir and the cardiotomy reservoir, prominent in the cardiopulmonary bypass circuit have weakness.… more
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