Abstract:DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of blindness in the world. Diabetic macular edema (DME) and retinal neovascularization (NV) are the two major pathological alternations leading to the vision loss in diabetic… more
Abstract:DESCRIPTION (provided by applicant): Vascular leakage or increased vascular permeability in the retina is a common abnormality of diabetic retinopathy and can result in diabetic macular edema (DME), a major cause of vision loss in diabetic patients. Currently, there is no effective drug therapy to… more
Abstract:Transmissible spongiform encephalopathies (TSEs), or prion diseases, are caused by a unique transmissible agent hypothesized to be a misfolded form (PrPD) of a normal host protein (PrPC). We will use chronic wasting disease (CWD) as a model prion agent because there is an urgent need for increased… more
Abstract:This Small Business Technology Transfer Phase I project proposes the joint development of a compact/portable laser spectroscopic trace gas sensor based on quartz-enhanced photo-acoustic spectroscopy (QEPAS) recently demonstrated in the lab. QEPAS uses a low cost quartz tuning fork as the sensing… more
Abstract:This Small Business Technology Transfer (STTR) Phase I research project proposes to develop new methods for blue/UV laser fabrication. These new devices will have the competitive advantages of higher emission intensities, higher reliability, and ability to extend emission into the deep UV spectral… more
Abstract:Bovine Respiratory Disease is the most costly disease among cattle arriving at feedlots and results in decreased weight gain, lower quality meat and death. BRD is highly transmittable and a rapid and sensitive diagnostic method for BRD is not currently available. This project will validate a… more
Abstract:An important problem facing rural America is the lack of job opportunities. This is particularly true in much of the arid southwestern U.S. These rural communities have little that they can export into commodity priced markets. Hence, this region has among the highest incidence (% of county… more
Abstract:DESCRIPTION (provided by applicant): Functional gastrointestinal motility diseases are common and make up about 40% of all gastroenterology patients. Typical esophageal motor disorders include dysphasia, gastroesophageal reflux disease (GERD), non-cardiac chest pain, etc., however the effective… more
Abstract:The objective of this proposal is to further explore PbSnSe detector array on Si substrate. Two approaches are proposed. One is a zero-risk incremental advance that employs a new growth condition to reduce the dislocation density. Another approach is a novel fabrication technique with high-risk but… more
Abstract:The goal of this work is the development of technology for detecting trace levels of explosives as an aid to force protection and for acquisition of forensic evidence. In Phase I of this effort we demonstrated that personnel involved in the manufacture, storage, deployment, and triggering of… more
Abstract:The goal of the project was to find a more efficient treatment for cancer while reducing the risk of radiation damage. To reach this goal, we propose a novel method for ovarian cancer treatment that combines radiotherapy and photodynamic therapy (PDT). Under this concept, luminescent nanoparticles… more
Abstract:Surface water quality impacts associated with intensive, largescale poultry production are significant and pervasive in many parts of the country. Production Specialities, Inc. (PSI) has developed process technology for converting waste (poultry litter and manure) into commercial eneefty and… more
Abstract:DESCRIPTION (provided by applicant): Obesity is a serious medical problem: in the United States alone, it causes approximately 300,000 deaths and estimated healthcare costs in the amount of $100 billion per year. However, currently available therapy remains unsatisfactory. In this project, we… more
Abstract:The short read range of current cattle electronic identification ear tags threatens to hinder the widespread adoption and utility of the USDA-developed National Animal Identification System (NAIS). Tag readers that require placement within inches of an animal's ear in order to read the NAIS number… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a new passivation technique, derived from a recent discovery that semiconductors can be readily hydrogenated by simultaneous exposure to hydrogen gas and ultra-violet light. The technique has a number of advantages over… more
Abstract:75239S Municipal solid waste landfills are the single largest source of anthropogenic methane emissions in the United States, producing 7 million tons, or 34% of the nation's total methane pollution. According to the Intergovernmental Panel on Climate Control¿s third assessment report, methane… more
Abstract:Anautics proposes to discover, research, and evaluate new technologies, methods and tools, as well as recommend demonstrated capabilities known to them through working with Industry, Universities, Aging Aircraft, CASI and COSSI projects. While many systems promise to integrate all aspects of your… more
Abstract:The proposed system shall have the ability to learn from past actions and recommend best course of action for a maintainer. The proposed research is expected to benefit managers, equipment specialists, engineers, planners, schedulers, supervisors, and mechanics. Cost and flow day reduction… more
Abstract:DESCRIPTION (provided by applicant): The goal of the Small Business Innovative Research Phase II is to develop an Internet-based Caregiver Support System (ICSS) that enables care to be provided to persons with Alzheimer's over the Internet. The objectives of the system are to improve the quality of… more
Abstract:DESCRIPTION (provided by applicant): Diabetic retinopathy is a common complication of diabetes mellitus and a leading cause of blindness in the developed countries. There are two major pathological changes which impair vision in diabetic retinopathy: diabetic macular edema (DME) resulting from… more
Abstract:DESCRIPTION (provided by applicant): Diabetic retinopathy is a common complication of diabetes and a leading cause of blindness in the US and the world. Diabetic macular edema (DME) and retinal neovascularization are the two major pathological alternations leading to the vision loss in diabetic… more
Abstract:DESCRIPTION (provided by applicant): Diabetic retinopathy is a common complication of diabetes. It affects millions people and is a leading cause of blindness in the industrialized countries. In diabetic retinopathy, there are two major pathological changes responsible for vision loss, diabetic… more
Abstract:Aircraft maintenance, repair, and overhaul (MRO) organizations face the challenging task of scheduling maintenance work without knowing the full extent of the work content at the time of initial inspection. During the overhaul, new work is discovered requiring rapid re-sequencing of tasks and the… more
Abstract:Bovine Respiratory Disease is the most common illness among cattle arriving at feedlots and results in decreased weight gain, lower quality meat and death. BRD is highly transmittable and costs cattlemen more than all other diseases combined. A rapid and sensitive diagnostic method for BRD is not… more
Abstract:Attacks using chemical warfare (CW) agents are a principal threat to the US homeland and deployed assets. This proposal focuses on demonstrating key capabilities required to develop a micro-gas analysis (MGA) system that provides orders of magnitude improvement in sensitivity and a very high degree… more
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