Abstract:Antibody-based receptor scaffolds used in chemical and biological sensors suffer from certain inherent shortfalls. We propose an approach based on the use of computationally designed proteins as receptor scaffolds. Such receptor scaffolds overcome many of the problems encountered with antibodies.… more
Abstract:Under funding from DARPA, Nomadics has demonstrated the potential for deploying multi-gun fixtures as a means of defeating rocket-propelled grenades (RPGs). These early tests have created a database that will be invaluable in advancing the work toward optimization of the initial concept through… more
Abstract:By mechanically attacking the nose/warhead of a rocket-propelled grenade (RPG), one can render the RPG into a purely kinetic projectile rather than an explosive one. This can be achieved by shearing the nose fuze, collapsing the ogive, or disrupting the explosive itself. While a 2.5 kg projectile… more
Abstract:The goal of the proposed research is to develop a cell culture model for elk chronic wasting disease (CWD) prion propagation that can be used as a bioassay for detecting CWD. Our goal will be accomplished by bioengineering a bovine B-lymphocyte cell (B-cell) line to surface express elk PrPc fused to… more
Abstract:Nomadics proposes to implement its proven Fido explosives detection system to produce a system specifically designed to identify the trace chemical signature of explosives on personnel who may be involved in the fabrication or transport of improvised explosive devices (IEDs), including suicide bombs… more
Abstract:High chemical activity of chlorine and severe health effects after even short-term exposure to it make facilities that use chlorine are subject for potential terrorist attacks. The magnitude of such attacks on U.S. chemical facilities could easily exceed the loss of life suffered on September 11th.… more
Abstract:All explosive devices, including IEDs, have chemical signatures that to date have been underexploited as a means of detction. Nomadics is proposing to employ chemical sensing methods to determine if suspected items contain explosive elements or not. Using the Fido ultra-trace detector as the core… more
Abstract:This Small Business Innovative Research (SBIR) Phase II project will develop and introduce new low-dielectric constant polymers as a new dielectric material for the fabrication of interconnect systems in integrated circuits. The continuing drive for denser integrated circuits and faster… more
Abstract:76293-With network bandwidth increasing more rapidly than processor speed for the past two decades, a serious performance problem exists for the transport, storage, and retrieval of large amounts of scientific data. The client of a clustered file system, which acts as the middleman between the Grid… more
Abstract:This Small Business Innovation Research Phase I project is a feasibility study of developing a terabyte size database server using advanced software technology developed for supercomputer cluster and scientific computation. With today.s rapid proliferation of information, organizations are facing… more
Abstract:R4 (Rapid, Reusable, Repeatable, Removable) tooling system. In this project a method of making and using a reusable mandrel, which can be made rigid for use as a tool for formation of the internal surfaces of composite parts, will be developed. This closed system makes it environmentally safe and… more
Abstract:RTA Systems, Incorporated and their teaming partner, Terra Environmental Products Company (TEPCO) propose to develop a novel, spray-applied, water-based, two-part liquid formulation that can effectively clean Chemical/Biological (CB) agents from the surface of materials/parts and components and… more
Abstract:DESCRIPTION (provided by applicant): Clinical practice guidelines recommend implementation of nighttime incontinence care that minimizes sleep disruption for nursing home residents. However, these guidelines offer no specific intervention recommendations. Investigators propose a method to… more
Abstract:DESCRIPTION (provided by applicant): Normal recruitment of circulating white blood cells (leukocytes) into tissues is important in inflammation, lymphocyte homing, and immunological responses. The mechanism of recruitment involves receptors termed selectins that recognize their counter receptors on… more
Abstract:The overall goal of SouthWest Nanotechnologies (SWeNT) is the development of superior technology for the large-scale manufacturing and marketing of nanotubes of unique quality for near-term specialty applications. The Phase I of this SBIR focused in demonstrating that SWeNT's process can be… more
Abstract:Typically, the path to site closure is a very long and indirect one. The current accepted "trial and error" method of drilling and sampling monitor wells, and based on the sample results, drilling and sampling additional wells, is neither efficient nor cost effective. Site delineation can often… more
Abstract:Secondary fire detection in P&W 100 engines used on F-15 and F-16 aircraft are detected by a 1970's technology Light Off Detector (LOD). The LOD is bulky and heavy. They are also expensive and therefore repair kits must be purchased and personnel trained to maintain them. There are reliability… more
Abstract:DESCRIPTION (provided by applicant): Gastroparesis is a common disease defined as the delayed emptying of the stomach. It is present in at least 20% of about 150 million patients with diabetes worldwide and in more than 20% of patients with functional dyspepsia that affects about 10-25% of the… more
Abstract:The objective of this proposal is to develop a portable and accurate means of detecting and accurately characterizing corrosion in multiple layered structures made of dissimilar metals. The proposed approach is to apply technology that was developed for ultrasonic imaging. Of particular interest… more
Abstract:DESCRIPTION (provided by investigator): The Iong-term objective of Small Business Innovative Research Phase I is to develop an Internet based Alzheimer's Caregiver Support System (iACSS). The iACSS would enable care to be provided remotely to individuals with Alzheimer's disease over the Internet.… more
Abstract:NON-TECHNICAL SUMMARY: Short Tandem Repeat (STR) loci consist of short, repetitive sequence elements ranging from 2 to 5 base pairs (bp) in length distributed throughout mammalian genomes (microsatellites). STR genotypes can be determined from polymerase chain reaction (PCR) products of less 500 bp… more
Abstract:Concerns regarding both the presence of endocrine disruptors in food, water, or other environmental media as well as the potential risk they pose to humans and wildlife have been growing in recent years. Passage of the Food Quality Protection Act and Amendments to the Safe Drinking Water Act… more
Abstract:Fort Environmental Laboratories, Inc.¿s Phase I research project resulted in the development and standardization of an assay that tests substances that might disturb reproductive and developmental processes in animals by interfering with the endocrine system. The primary goal of the proposed… more
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