Abstract:DESCRIPTION (provided by applicant): The objective of this project is to develop a commercially viable point of care Rapid HIV-1 Incidence Assay and establish its suitability for determination of recency of HIV-1 infection in whole blood, plasma, serum specimens for epidemiological, research and… more
Abstract:DESCRIPTION (provided by applicant): The objectives of this project are to develop a commercial single well HIV-1 Limiting Antigen Avidity EIA, developed in Phase I as a research tool, and establish its suitability for identifying recent HIV-1 infections on both a population an on an individual… more
Abstract:DESCRIPTION (provided by applicant): The longterm goal of this project is to utilize cytomegalovirus (CMV) vectors carrying oncogenes of high risk human papillomaviruses (HPV) as novel therapeutic vaccines against cervical cancer. Although recently launched prophylactic vaccines protect against HPV… more
Abstract:DESCRIPTION (provided by applicant): The longterm goal of this project is to utilize cytomegalovirus (CMV) vectors in the development of a therapeutic vaccine against herpes simplex virus 2 (HSV-2), the causative agent of genital herpes. HSV-2 is widely prevalent in the population causing recurrent… more
Abstract:DESCRIPTION: The ultimate goal of this project is to develop an immunotherapy for human immunodeficiency virus (HIV)-1 based on a spread-deficient cytomegalovirus (CMV)-derived vaccine expressing tailored antigens designed for maximal coverage of clade Bepitopes. In non-human primate models,… more
Abstract:Aging, the progressive degeneration of body and mind, is a universal problem marked by a decline in tissue organization and function, and an increase in the likelihood of death. Progress in understanding the cellular and molecular basis of aging is rapidlyaccelerating, following the discovery that… more
Abstract:DESCRIPTION (provided by applicant): Project Summary/Abstract Treatment of acute ischemic stroke (AIS) with the thrombolytic/antithrombotic agent tissue plasminogen activator (tPA, Activase(R)) is limited due to the potential for severe hemorrhagic side effects. The first symptoms of acute ischemia… more
Abstract:DESCRIPTION (provided by applicant): Rapidly progressing occlusion of the coronary artery and the subsequent acute myocardial ischemia is the most prevalent primary cause of acute myocardial infarction (AMI) and death in the United States. Early recanalization and antithrombotic therapy promotes… more
Abstract:This Small Business Innovation Research Phase I project assesses the technical feasibility of the amorphous metal non-linear resistor as a transformational display technology. This technology challenges conventional display industry wisdom by using tunneling electronics, enabled through innovative… more
Abstract:Acute challenges are faced by the designers of fluid transport systems for spacecraft because of the persistently unfamiliar and unforgiving low-g environment. However, with modern design tools capillarity can used to passively perform critical life support functions, increasing reliability, while… more
Abstract:The ISTAR Group ( IG) and team mate Thin Red Line Aerospace (TRLA) propose a Venus altitude cycling balloon (Venus ACB), an innovative superpressure balloon architecture that is ideally suited to cloud level mission parameters and to incorporation of a variety of buoyancy control mechanisms that… more
Abstract:World marine food farming production (aquaculture) is dependent on hatchery and nursery production of large quantities of high quality larvae and juvenile shellfish, shrimp and fish. Bacterial diseases, particularly vibriosis, are a major cause of mortality in hatcheries and nurseries and causelarge… more
Abstract:DESCRIPTION (provided by applicant): The proposed project described in this grant application, combined with existing Fluorish tools, will create a robust cloud-based e-commerce marketplace for cytometry research reagents, addressing key needs in the research community. Flow Cytometry is widely… more
Abstract:Sagetech proposes a program that will give rise to a 150 gram Mark XIIA Level 2 IFF Micro-Transponder with ADS-B that meets all requirements for deployment in a Group 2 UAV. The device will be designed to interface initially with a KIV-77 crypto applique, but will be replaced by a micro-KIV in… more
Abstract:ABSTRACT: Lightfield 3D displays are being developed to reduce viewer eyestrain normally found on stereoscopic displays caused by the mismatch of the focus and stereo vergence on the display. These lightfield or Field of Light Displays (FoLD) systems generate a light field by any of several… more
Abstract:DESCRIPTION (provided by applicant): A hallmark of virtually every cancer is aberrant epigenetic silencing of vital genes required for a normal cell cycle and genome stability (e.g. MLH1, BRCA1, VHL, p16, etc.). Loss of expression of these tumor suppressorgenes plays a critical role in cancer… more
Abstract:The QED team proposes an Advanced Payload Handling System (APHS) capable of semi-autonomous and/or wireless remotely controlled, omni-directionally maneuvering operations. Selected design candidates will be evaluated with respect to their ability to provide an assured capability of acquiring and… more
Abstract:DESCRIPTION (provided by APPLICANT): An overlooked, neglected, yet significant problem in the United States today is the use and abuse of tobacco, alcohol, and other drugs by individuals with intellectual disabilities (ID). Increasing numbers of people with ID are living independently in the… more
Abstract:The TAU Performance System is a powerful and highly versatile profiling and tracing tool ecosystem for performance analysis of parallel programs. Developed over the last 15 years, TAU has evolved with each new generation of HPC systems and scales efficiently to hundreds of thousands of cores on the… more
Abstract:DESCRIPTION (provided by applicant): Topical fluorides have been the mainstay in the prevention of dental caries for decades. However, topical fluoride alone is not enough to thwart tooth decay in high-risk populations. The purpose of this Phase I application is to determine the technical and… more
Abstract:The project goal is to develop and test the feasibility of a self-management system, Goal
Guider, consisting of a mobile application and companion web site that allows individuals with intellectual disabilities and autism to effectively manage self-defined goals for everyday living across various… more
Abstract:Summary Sleep disordered breathing (SDB) is believed to be a widespread, under-diagnosed condition associated with detrimental health problems, at a high cost to society. The current gold standard for diagnosis of SDB is a time- consuming, expensive, and obtrusive (requiring many attached wires)… more
Abstract:Scandate cathodes are proposed as a way to boost performance and life for electric space propulsion systems. This company has recently demonstrated breakthrough performance on these cathodes in other formats. We have demonstrated emission of 5 Amps/cm2 at 850 degrees CB, which is 200 degrees C… more
Abstract:We propose to build an electrostatically focused klystron that exploits recent breakthroughs in scandate cathode technology. We have built cathodes with greater than 100 Amps/cm2 emission. This project offers an opportunity to test those cathodes in real world devices. Because of their small size… more
Abstract:Modular software development helps enable application developers to quickly write sophisticated applications. However, in most instances only a small fraction of the functionality included in a particular software components is needed. Not only is there a performance cost, but the prevalence of… more
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