Abstract:Over one million women worldwide are diagnosed with breast cancer each year. Roughly 20% of all breast cancers overexpress the human epidennal growth receptor 2 (HER2-positive subtype). HER2-targeted therapies, including Herceptin and lapatinib, account for 55% of the breast cancer therapy market in… more
Abstract:DESCRIPTION (provided by applicant): Although balance and gait disorders are one of the most common and devastating chronic medical problems of older people, especially those with chronic neurological diseases, clinicians or clinical researchers do not measure balance and gait frequently,… more
Abstract:Intelligent tutoring systems (ITS) are complex adaptive learning systems that simulate one-on-one tutoring. Research shows they improve learning and reduce time to mastery. Unfortunately, they are also expensive and time-consuming to produce. Existing IT authoring tools eliminate low level… more
Abstract:The flexFORCE engineering team has completed assessment of the critical technical factors required for successful ASP deployment (weight, pointing accuracy, control response, actuation power required, failure modes and effects, scalability, and manufacturability). The team has evaluated the ASP… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to synthesize, based on genomic sequence information, a human cytomegalovirus (HCMV) strain with demonstrated ability to establish persistent infection in sero-positive individuals. The resulting synthetic product will form the basis… more
Abstract:This Small Business Innovation Research Phase I project proposes to demonstrate and develop a prototype of a minimally-invasive drug delivery technology to address the need for a more practical and effective transtympanic drug delivery system. The technology combines a proprietary trocar catheter… more
Abstract:DESCRIPTION (provided by applicant): Rapidly progressing occlusion of the coronary artery and the subsequent acute myocardial ischemia is the most prevalent primary cause of acute myocardial infarction (AMI) and death in the United States. Early recanalization and antithrombotic therapy promotes… more
Abstract:This project team is developing a prototype of software for a tablet computer to replace paper tests for teachers to assess the reading fluency of special education students in grade 5 and 6. The technology will provide: scoring and tracking assessments with a stop watch for appropriate timing of… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will demonstrate proof of concept and validate the feasibility of translating a molecular receptor for nitrate anion into a highly-selective and sensitive soil probe. Ultimately, these sensors will fulfill the need for real-time… more
Abstract:The goal of this Phase I project is to develop an engineering plan and to create a prototype for a mobile, cloud-based expert system to aid in diagnosis, decision support and predictive analytics to improve clinical outcomes for veterans, soldiers, and their families with traumatic brain injury… more
Abstract:Inspired Light is developing a high-efficiency Concentrating Photovoltaic (CPV) system that requires accurate, 2-axis tracking. Available tracking systems are too large, expensive and require specialized setup procedures that are incompatible with a very low cost, versatile deployment strategy.… more
Abstract:Acute challenges are faced by the designers of fluid systems for spacecraft because of the persistently unfamiliar and unforgiving low-g environment. For example, most fluid systems aboard spacecraft are impacted by the presence of capillary forces?a poor understanding of which has led to poorly… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is focused on the demonstration of a real-time high-contrast Terahertz (THz) imaging system, based on frequency upconversion of THz images into the near infrared (NIR) spectral range. Due to low power of compact THz sources and poor… more
Abstract:DESCRIPTION (provided by applicant): PROJECT SUMMARY Although prophylactic vaccines have potential for prevention of high risk human papilloma virus (HPV) infection they have no therapeutic efficacy. It has been estimated that there will be no measurable decline of HPV- associated tumors before 2040… more
Abstract:DESCRIPTION (provided by applicant): Type 1 diabetes often leads to short-term and long-term complications which impair quality of life. Though many research groups are developing versions of an artificial endocrine pancreas (AP) system, current systems require at least one hormone delivery… more
Abstract:This Small Business Innovation Research Phase I project advances a novel method to fabricate 3D IC interconnects. Physical and economical limitations for 2D scaling (Moore's Law) prevents further increase of integration density to improve the performance of integrated circuits (IC). These… more
Abstract:This Small Business Innovation Research Program (SBIR) Phase I project is to design and develop an automatic conformance checking solution that can quickly detect inconsistencies between virtual devices and hardware prototypes. Computer and consumer electronics manufacturers are facing increasingly… more
Abstract:The proposed effort to develop a modular Hybrid UAV Propulsion system whereby the best ICE or Turbine generator can be integrated as it is developed. Northwest UAV Propulsion Systems will work with AMRDEC and utilize the data collected on several EM and ESC that AMRDEC has tested over the last year.… more
Abstract:DESCRIPTION (provided by applicant): (Phase-2, Renewal) The SACC-Substance Addiction Collaboration Channel(R) platform is a new Collaboration, WEB-2.0 springboard specifically designed to structure and share information across the Behavioral/Mental Health Workforce community with the special… more
Abstract:DESCRIPTION (provided by applicant): The presence of islet-directed auto-immunity and associated circulating auto-antibodies, previously thought to be primarily characteristic of type-1 diabetes mellitus (T1DM), is now apparent in a proportion of individuals with putative type-2 diabetes (T2DM),… more
Abstract:DESCRIPTION (provided by applicant): Development of a phase 2 beta for demonstration in Tree Top juice processing plant of a Field Applicable Real-time Remote Monitoring Sensor Device capable of detecting multiple pesticides simultaneously in unfiltered juice, fluid or waste water. We propose to… more
Abstract:The QED team proposes a study of an independent seagoing barge that can be attached to and made a part of an INLS or commercial RRDF floating platform. The barge contains an active motion compensation platform supported by either a self-contained air cushion, hydraulic/mechanical apparatus or a… more
Abstract:DESCRIPTION (provided by applicant): The problem of overweight children with intellectual disabilities (ID) has many adverse medical and psychological effects and is of growing concern among professionals in the disability research and advocacy arenas. Toaddress this issue, we propose to develop… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to optimize and demonstrate the scale-up of nanostructured anti-reflective coatings (ARCs) to meet the specifications of solar energy customers using high-performance processes along with a novel solution-phase synthesis and… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project focuses on the further development of an advanced, mobile, easy-to-use, patient-oriented, advanced Home Hemodialysis (HHD) system that minimizes the use of water (less than 6 liters) and medical waste, and importantly, minimizes… more
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