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Displaying 1626 – 1650 of 1931 Awards
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 2
Abstract: THE TRANSDERMAL ROUTE TO DRUG DELIVERY HAS THE ADVANTAGES ASSOCIATED WITH RATE-CONTROLLED DRUG-DELIVERY SYSTEMS (E.G.,GREATER SAFETY, EFFECTIVENESS, AND CONVENIENCE). IN ADDITION, UNLIKE OTHER RATE-CONTROLLED SYSTEMS, TRANSDERMAL DRUG DELIVERY AVOIDS HEPATIC "FIRST-PASS" EFFECTS AND GASTROINTESTINAL… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: NSF / SBIR / 1992 / 2
Abstract: THE PROPOSED WORK IS DIRECTED TOWARD THE DEVELOPMENT OF A NOVEL AND HIGHLY SELECTIVE MEMBRANE FOR THE CONTINUOUS PURIFICATION OF VALUABLE PROTEINS SUCH AS INTERFERON FROM COMPLEX AND DILUTE MIXTURES. PRODUCTION OF PROTEINS REQUIRES THREE MAIN STEPS: (1) FERMENTATION OR CELL CULTURE;(2) ISOLATION;… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: NSF / SBIR / 1992 / 2
Abstract: MANY PESTICIDES ARE CHIRAL--THAT IS, THEIR CHEMICAL STRUCTURES EXIST AS A PAIR OF "HANDED" STEREOISOMERS CALLED ENANTIOMERS. CHIRAL PESTICIDES GENERALLY EXHIBIT ENANTIOSELECTIVE ACTION, WHERE ONLY ONE ENANTIOMER IS ACTIVE AND EXHIBITS THE DESIRED BIOLOGICAL ACTIVITY. DESPITE MOUNTING EVIDENCE THAT… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: DOE / SBIR / 1992 / 2
Abstract: NATURAL GAS PROVIDES AN INCREASINGLY IMPORTANT PORTION OF THE U.S. ENERGY SUPPLY. ESTIMATED U.S. GAS RESERVES ARE ABOUT 1,000 TRILLION STANDARD CUBIC FEET (SCF), OR ABOUT 1,000 QUADS. ALL NATURAL GAS AT THE WELLHEAD CONTAINS CONTAMINANTS THAT MUST BE REMOVED BEFORE THE GAS IS TRANSPORTED THROUGH… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: NSF / SBIR / 1992 / 2
Abstract: THE USE OF PROTECTING GROUPS IS A VITAL TOOL IN THE SYNTHESIS OF MULTIFUNCTIONAL MOLECULES SUCH AS VALUABLE "NEWGENERATION" PHARMACEUTICALS. WHEN A REACTION MUST BE CARRIED OUT AT A SPECIFIC REACTION SITE, PROTECTING GROUPS ARE USED TO TEMPORARILY BLOCK OTHER SENSITIVE REACTION SITESON THE MOLECULE.… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 2
Abstract: PROTEINS ARE INCREASINGLY BEING USED AS PHARMACEUTICALS, DIAGNOSTIC AGENTS, CATALYSTS IN BIOCHEMICAL PROCESSES, AND GROWTH PROMOTERS IN MAMMALIAN CELL CULTURE. COMMERCIAL PROCESSES INVOLVING THE ISOLATION, STORAGE, AND USE OF THIOL-CONTAINING PROTEINS ARE HAMPERED BY THE LACK OF PRACTICAL PROCESSES… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 2
Abstract: ONE GOAL OF MEDICAL RESEARCH ON HEMATOPOIESIS-THE GROWTH AND DIFFERENTIATION OF PLURIPOTENT STEM CELLS WITHIN THE BONE MARROW-IS TO DUPLICATE THAT PROCESS IN VITRO FOR TREATMENT OF DISEASE. CURRENT METHODS ARE PLAGUED BY THE INHERENT COMPLEXITY OF THE PROCESS; FOR EXAMPLE, THE SAME GROWTH FACTORS… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: DOE / SBIR / 1992 / 2
Abstract: AS THE U.S. SEEKS ENERGY INDEPENDENCE, COAL CONVERSION AND UTILIZATION PROCESSES WILL PLAY AN INCREASINGLY IMPORTANT ROLE IN PROVIDING ENERGY SOURCES. FOR THESE PROCESSES TO BESUCCESSFULLY EXPLOITED, METHODS MUST BE DEVELOPED FOR REMOVING CONTAMINANTS, PARTICULARLY HYDROGEN SULFIDE (H2S), FROM THE… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: DOE / SBIR / 1992 / 2
Abstract: TO IMPROVE THE ECONOMICS OF PRODUCING SYNFUELS FROM COAL, NOVEL METHODS ARE SOUGHT OF INTEGRATING COAL GASIFICATION WITH WATER-GAS SHIFT REACTIONS. BECAUSE OF EQUILIBRIUM LIMITATIONS THE WATER-GAS SHIFT REACTION (CO + H2O CO2 + H2) CURRENTLY REQUIRES TWO REACTORS FOR OBTAINING HIGHHYDROGEN (H2)… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: NSF / SBIR / 1992 / 1
Abstract: IN RESPONSE TO THE NSF'S CALL FOR INNOVATIVE ENGINEERING APPROACHES TO WASTEWATER TREATMENT, WE PROPOSE A NEW BIOREMEDIATION PROCESS THAT RELIES ON ENZYMES THAT CATALYZE DEGRADATION OF POLLUTANTS, IMMOBILIZED IN A NOVEL MEDIUM. THE PROCESS WOULD BE DESIGNED TO PRETREAT MANY OF THE SAME WASTEWATERS… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: NASA / SBIR / 1992 / 2
Abstract: INTEGRATED PHYSICOCHEMICAL, BIOLOGICAL CLOSED-LOOP LIFE-SUPPORT SYSTEMS MUST BE DEVELOPED FOR HUMANS TO UNDERTAKE EXTENDED EXTRATERRESTRIAL MISSIONS. THESE SYSTEMSALMOST CERTAINLY WILL INCLUDE SEPARATE BUT INTEGRATED PLANT AND HUMAN HABITATS, NOT ONLY TO PROVIDE FOOD FOR HUMANS AND RECYCLE THEIR… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: NASA / SBIR / 1992 / 2
Abstract: NASA IS INVESTIGATING THE USE OF PLANT-GROWTH CHAMBERS (PGCS) FOR SPACE MISSIONS AND FOR BASES ON THE MOON AND MARS. PGCS SERVE SEVERAL IMPORTANT PURPOSES; OXYGEN AND FOOD PRODUCTION, CARBON-DIOXIDE REMOVAL, AND WATER PURIFICATION AND REUSE. KEY TO THE SUCCESSFUL DEVELOPMENT OF PGCS IS A SYSTEM THAT… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: DOE / SBIR / 1992 / 1
Abstract: MICROBIAL OXIDATION OF AROMATIC HYDROCARBONS IS A POWERFUL TECHNIQUE FOR OBTAINING HIGH VALUE INTERMEDIATES USEFUL FOR SYNTHESIS OF PHARMACEUTICALS, PESTICIDES, SPECIALTY POLYMERS, AND OTHER VALUABLE CHEMICALS. INEXPENSIVE FOSSIL-FUEL-DERIVED FEEDSTOCKS SUCH AS BENZENE, TOLUENE, AND NAPHTHALENE CAN… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: DOE / SBIR / 1992 / 1
Abstract: THE POTENTIAL ADVANTAGES OF MEMBRANE-BASED PROCESSES FOR SEPARATIONS ARE WELL KNOWN, BUT CURRENT MEMBRANE SYSTEMS HAVE CAPTURED ONLY A SMALL FRACTION OF THE TOTAL SEPARATIONS MARKET-PRIMARILY BECAUSE CURRENT MEMBRANES DO NOT OFFER THE COMBINATION OF HIGH SELECTIVITY AND HIGH FLUX REQUIRED FOR MANY… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: OPIOID PEPTIDES ARE AN IMPORTANT CLASS OF BIOREGULATORS, INVOLVED IN PAIN RECOGNITION, AND GASTRIC, RESPIRATORY, AND BEHAVIORAL PROCESSES. TO SUPPLY OPIOID PEPTIDES FOR RESEARCH USE AND EVENTUALLY PHARMACEUTICAL USE, NEW METHODOLOGIES FOR THE SYNTHESIS OF OPIOID PEPTIDES MUST BE DEVELOPED THAT AVOID… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: THE OBJECTIVE OF THIS PROJECT IS TO DETERMINE THE FEASIBILITY OF DEVELOPING AN NOVEL ENZYMATIC PROCESS FOR THE SEMI-SYNTHESIS OF TAXOL. TAXOL IS A PROMISING DRUG FOR TREATMENT OF OVARIAN AND OTHER CANCERS. HOWEVER, IT IS CURRENTLY AVAILABLE ONLY IN LIMITED QUANTITY BY EXTRACTION FROM A RARE TREE;… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: DOD / SBIR / 1992 / 1
Abstract: 1The Navy has been investigating membrane distillation (MD) as a means of desalinating seawater aboard ships since 1983. MD could potentially offer advantages over conventional distillation, the technology in most common use now, and could offer an alternative to other promising membrane… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: CHIRAL DRUGS ADMINISTERED IN ENANTIOMERICALLY PURE FORM OFFER SIGNIFICANT CLINICAL ADVANTAGES OVER THEIR RACEMIC COUNTERPARTS. HOWEVER, AVAILABLE METHODS TO PREPARE ENANTIONMERICALLY PURE COMPOUNDS HAVE DRAWBACKS, INCLUDING HIGH COST, LIMITS ON CHEMICAL AND ENANTIOMERIC PURITY, AND DIFFICULTY WITH… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: N/A
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: DOE / SBIR / 1992 / 1
Abstract: N/A
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: DOE / SBIR / 1992 / 1
Abstract: N/A
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: EPA / SBIR / 1992 / 1
Abstract: N/A
Company: COVALENT ASSOC., INC. Agency/Program/Year/Phase: NASA / SBIR / 1992 / 2
Abstract: HIGH-ENERGY-DENSITY, RECHARGEABLE LITHIUM BATTERIES ARE BEING CONSIDERED BY NASA FOR FUTURE MANNED AND UNMANNED MISSIONS. BECAUSE LITHIUM BATTERIES CONTAINING NON-AQUEOUS ELECTROLYTES ARE HIGHLY SENSITIVE TO OVERCHARGE, ESPECIALLY WHEN INDIVIDUAL CELLS ARE CONNECTED IN SERIES, AN ADEQUATE OVERCHARGE… more
Company: COVALENT ASSOC., INC. Agency/Program/Year/Phase: DOE / SBIR / 1992 / 1
Abstract: N/A
Displaying 1626 – 1650 of 1931 Awards
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