Abstract:DESCRIPTION (provided by applicant): This application is a Phase II STTR to further the study of a novel therapeutic intervention for ischemic stroke. Phase I investigated the mechanism of protection against ischemic stroke provided by the novel designertherapy, recombinant T cell receptor ligand… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to create better diagnostic testing for drug, food, and environmental allergies. If successful, it would be transformative in the clinical diagnosis of allergy diseases by enabling rapid evaluation at the doctor?s office in a… more
Abstract:DESCRIPTION (provided by applicant): Virogenomics is currently developing a portable, electrochemical device for rapid disease diagnosis of multiple indications. The basis of our approach is a patent-pending electrochemical immunoassay performed on patterned electrode arrays, and we take advantage… more
Abstract:ABSTRACT: To address the need for covert, transparent optical taggants, which can upconvert and downconvert greater than 100 nm when stimulated by either 830 nm or 1064 nm laser light, a series of wide bandgap doped metal oxide nanoparticles will be developed and demonstrated. In Phase I,… more
Abstract:Large-area (3m2), UV-sensitive focal plane arrays are needed for observation of air showers from ultra-high energy cosmic rays (JEM-EUSO) as well as for visible-wavelength spectrographic and photometric instruments planned for future telescopes (OWL). Existing photocathode-based technologies for… more
Abstract:High-performance HDTV cameras are commercially widespread, but are not presently available in radiation-hard versions. The objective of the proposed SBIR effort is to develop and commercialize a radiation-hard, high-performance HDTV sensor for NASA missions and other space-based and high-energy… more
Abstract:There is a need for developing a high-performance Geiger-mode avalanche photodiode (Gm-APD) array design, which can be fabricated using a domestic, high-volume commercial CMOS process on 200mm or greater wafers. Most of todays silicon photomultipliers (SiPMs) and single photon … more
Abstract:Pumpprobe experiments are a powerful tool for directly studying the molecular dynamics of chemical reactions and energy transfer processes as they unfold on the femtosecond or picosecond time scale. Pumpprobe experiments with xray probes, where a chemical reaction is initiated by a first optical… more
Abstract:Available 2D multiwire proportional counters (MWPC) are limited by their low global countrate capability and are insufficient for imaging XCS (xray crystal spectroscopy) experiments. Solid state xray pixilated array detectors have been shown to overcome this problem. However, large area solid … more
Abstract:The need for domestic sources of improved-performance single photon counting detectors (SPDs) is important for the advancement of science. SPDs are proving invaluable for studying intracellular processes, charged particle physics, adaptive optics for extremely large telescopes, and numerous other… more
Abstract:A full, wafer scale nanocrystal detector technology will be used to fabricate compact, light weight, low power, low cost short-wavelength infrared (SWIR) sensors. This approach is based on integration of inorganic nanocrystal films with large-format, small-pixel-pitch CMOS readout integrated… more
Abstract:ABSTRACT: CMOS silicon imagers are the dominant focal plane arrays for visible light imaging. Over several decades, there have been investigations in broad near-infrared (NIR) spectral response using laser doped and structuring silicon (Si) detectors, including so-called"black"silicon… more
Abstract:ABSTRACT: There is an increasing awareness of the advantages of solution-processed mesoscopic semiconductor devices. Compared to epitaxially-grown, lattice-matched, crystalline semiconductors, solution-processed optoelectronics offer fabrication without expensive and energy-intensive… more
Abstract:ABSTRACT: Addressing the demands of high frame-rate, large-format hyperspectral imagers, the design of a custom readout integrated circuit (ROIC) will be developed. The hyperspectral imaging ROIC will feature flexible operating readout modes including row (wavelength) programmable (i) gain, (ii)… more
Abstract:ABSTRACT: The printed nanocrystal detector technology will enable low cost, wide-spectral-response imagers. Phase I will use high volume synthesis methods where nanocrystal films will be fabricated and characterized. Solution processing allows nanocrystal films to be deposited or printed directly… more
Abstract:ABSTRACT: Voxtel proposes the development of a novel burst mode Wavefront/Wavefunction focal plane array (FPA), with a 64 64 InGaAs detector array composed of 36 36µm2 pixel elements with quantum efficiency greater than 95% across the near infrared (NIR) spectral range from 1 to 1.5µm. The… more
Abstract:ABSTRACT: Voxtel"s proposes the development of a High Energy Event Tracking (HEET) readout integrated circuit (ROIC), optimized for the identification and tracking of high energy events within a large format staring infrared sensor. Working with the AFRL program office, in Phase I, Voxtel has… more
Abstract:ABSTRACT: A large area, linear mode 950nm-1650nm sensitive avalanche photodiode (APD) LADAR receiver will be developed, characterized, and delivered. Such receivers are needed to enhance the capability of small platforms such as missile interceptors and unmanned aerial systems (UAS). In… more
Abstract:Widely proliferated sea mines present difficult challenges to the Navy"s ability to guarantee assured access to critical regions. To counter these asymmetric threats, airborne LIDAR systems are being used, but early LIDAR sensor systems have had problems in terms of availability, cost, reliably… more
Abstract:Purpose: Prior research points to several features of technology-based math games that may be important for supporting the learning needs of students with or at-risk for disabilities. These include games that engage students in highly motivating narratives, provide focused foundational knowledge and… more
Abstract:DESCRIPTION (provided by applicant): Chimeric mice with highly humanized livers have multiple potential applications in research and preclinical drug development both in the academic and commercial settings . The applications include studies of human infectious diseases (hepatitis B and B,… more
Abstract:DESCRIPTION (provided by applicant): Each year, over 6 million fractures are treated in the United States at a cost in excess of 13 billion. Between 5-8% of these fractures experience complications, particularly in the steadily increasing population withosteoporosis. By providing better fixation… more
Abstract:DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the leading cause of chronic disability in the United States. A clinical goal in the treatment and prevention of OA is to develo replacement cartilage using tissue engineering (TE) technologies.Although TE cartilage currently lacks the… more
Abstract:Energy consumption in the US increased threefold over the past fifty years, while the energy consumed by US buildings during that same period increased 4.3 X.(USEIA) Architectural Applications (a2) is developing a membrane-based heat and moisture exchanger that reduces the air conditioning energy… more
Abstract:DESCRIPTION (provided by applicant): Type 1 diabetes often leads to short-term and long-term complications which impair quality of life. Many research groups, including ours, are developing an artificial endocrine pancreas (AP), which combines continuous glucose sensing with automated hormone… more
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