Abstract:DESCRIPTION (provided by applicant): Most current chemotherapeutics have non-specific mechanisms of action and poor biodistribution profiles which result in dose-limiting toxicities tha prevent optimal efficacy from being obtained. Ribonucleic acid interference (RNAi) has the potential to be a safe,… more
Abstract:Hook and loop closures in Army uniforms have been identified as the critical sources of leaks in protective clothing/equipment, which limits the overall protective capability of the ensemble. We demonstrated during Phase I of this project that we can design and fabricate hybrid closure systems which… more
Abstract:DESCRIPTION (provided by applicant): Ion channels, such as Kv1.3 and Nav1.7, are involved in a number of human disorders, including autoimmunity and pain that affect gt100 million Americans annually and are poorly treated. However, ion channels are typically exceptionally difficult to express at… more
Abstract:DESCRIPTION (provided by applicant): Cells require the ability to detect and respond to stimuli in their surroundings, including to endogenous metabolites, exogenous nutrients, and environmental irritants. The proteins that are responsible for this processare called chemosensors and are involved in… more
Abstract:ABSTRACT Acute and chronic pain resulting from injury, surgery, or disease afflicts gt100 million Americans each year, having a severe impact on mood, mental health, and quality of life and costing the U.S. approximately 600 billion in economic costs annually. For many patients, treatment options… more
Abstract:Current prosthetic technologies allow amputees to return to a form of normal life, but create new risks, such as improper socket fit, which can lead to a heightened risk for tissue damage that could result in infection and hospitalization. These risks could be minimized by using a sensor system to… more
Abstract:This proposal addresses the opportunity to develop an optimized power and data bus for aircraft rotor loads monitoring by offering an innovative solution that delivers high power density energy harvesting and reliable delivery of large volumes of data from a rotating frame to a fixed frame. The… more
Abstract:This Phase II SBIR proposal responds to a need for adaptive compliant actuator hardware that can adapt to a wide range of applications for human-robot interactions. Some tasks require high forces to lift, pull, or carry and other tasks require fine motor control and precise motion. Human-robot… more
Abstract:KiON Defense Technologies, Inc. (KDT) has teamed with Lockheed Martin Aeronautics Company (LM) and Materials Research & Design, Inc. (MR & D) to demonstrate the effectiveness of a low areal density Thermal Protection System (TPS) for Navy reentry bodies. The new TPS system will incorporate… more
Abstract:Per the topic description, dense maritime environments pose significant challenges to naval airborne sensor systems with respect to surface target classification, track lifetime, and track association. A promising strategy to drastically improve situational awareness and reduce operator workload in… more
Abstract:Conventional CFAR detection processing has difficulty in heterogeneous clutter (i.e., maritime clutter) because the fixed data size windowing is not well matched to the spatial scales of the wave field over a wide range of sea states. The non-Gaussian nature of heterogeneous clutter gives rise to… more
Abstract:er the topic description, naval airborne sensor systems are utilizing or are planning to utilize varying degrees of automation in the prosecution of their missions as part of future naval capabilities. The automation must handle very dense maritime surface picture conditions that can exceed 1,000+… more
Abstract:Dense maritime environments pose significant challenges to naval airborne maritime sensor systems with respect to surface target classification because surface vessels of interest must often be separated from a larger number of similar looking surface vessels with non-threatening intent. Perhaps the… more
Abstract:DESCRIPTION (provided by applicant): In the last decade there has been an explosive growth in the field of ubiquitin research, with approximately 530 human genes predicted to encode enzymes involved in the conjugation and deconjugation of ubiquitin. Of these 95 encode deubiquitylases (DUBs) and… more
Abstract:DESCRIPTION (provided by applicant): Ubiquitin (Ub), a 76 amino acid protein, is implicated in protein degradation and a myriad of cell signaling pathways, including DNA damage response, protein trafficking, cell-cycle progression, inflammation, immune response and regulation of apoptosis.… more
Abstract:DESCRIPTION (provided by applicant): Identification, quantification, and isolation of low abundance proteins from complex mixtures is, at best, a difficult task. This is especially the case for proteins carrying a post-translational modification (PTM) that affects their half-life or regulatory… more
Abstract:DESCRIPTION (provided by applicant): This project, entitied Preclinical Development of Tracrolimus for Radiation Cystitis will fund key experiments to advance the commercial development of LP-10. LP-10 is a liposomal tacrolimus formulation for local (topical) intravesical administration to the… more
Abstract:DESCRIPTION (provided by applicant): Lipella Pharmaceuticals Inc. (Pittsburgh, PA) is a clinical-stage pharmaceutical company specializing in intravesical therapies for urinary bladder dysfunctions. Lipella is submitting a research proposal to the Small Business Technology Transfer program titled … more
Abstract:Missile modernization and future missile designs are utilizing more sophisticated and higher powered electronics in the pursuit of extended missile range, improved accuracy and precision targeting for striking enemy threats. Tight packaging and sophistication of these electronic systems can generate… more
Abstract:Advanced composite material systems are vital to the development of lightweight, multi-functional Army missile systems. In addition to reducing the weight of the structure, composite materials provide the ability to expand the function of the structure by tailoring stiffness and strength… more
Abstract:Efficient use of two-dimensional (2D) and three-dimensional (3D) woven carbon-carbon (C/C) composite materials used in many thermal protection applications requires that onset and development of material non-linearity be accounted for during design. The theoretical framework and computational… more
Abstract:The current welded aluminum ramps on the Navy"s Landing Craft Air Cushion (LCAC) hovercraft are prone to damage related to extreme vehicle and seaway load requirements in combination with corrosion and erosion due to the harsh salt-laden marine environment in which they operate. Improving… more
Abstract:ABSTRACT: Development and use of new composite materials is imperative for continued advancement of airframe and engine systems. In order to facilitate the accelerated insertion of new composite materials, there is a need for an improved analysis methodology that allows designers to reduce the… more
Composite materials often represent the most weight efficient and lowest cost solutions for airframe structures. Many of these structures are in areas that are susceptible to incidental impact damage and require adequate residual strength after impact for specified periods of service. … more
Abstract:In this proposal, Materials Sciences Corporation (MSC) and its manufacturing partner Seemann Composites Inc. (SCI) have defined several synergistic material science innovations that have the potential to lower the cost, or increase the performance at the current cost, of surface combatant sonar… more
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