Abstract:Dense maritime environments pose significant challenges to naval airborne maritime sensor systems with respect to surface target classification because surface vessels of interest must often be separated from a larger number of similar looking surface vessels with non-threatening intent. Perhaps the… more
Abstract:DESCRIPTION (provided by applicant): In the last decade there has been an explosive growth in the field of ubiquitin research, with approximately 530 human genes predicted to encode enzymes involved in the conjugation and deconjugation of ubiquitin. Of these 95 encode deubiquitylases (DUBs) and… more
Abstract:DESCRIPTION (provided by applicant): Ubiquitin (Ub), a 76 amino acid protein, is implicated in protein degradation and a myriad of cell signaling pathways, including DNA damage response, protein trafficking, cell-cycle progression, inflammation, immune response and regulation of apoptosis.… more
Abstract:DESCRIPTION (provided by applicant): Identification, quantification, and isolation of low abundance proteins from complex mixtures is, at best, a difficult task. This is especially the case for proteins carrying a post-translational modification (PTM) that affects their half-life or regulatory… more
Abstract:DESCRIPTION (provided by applicant): This project, entitied Preclinical Development of Tracrolimus for Radiation Cystitis will fund key experiments to advance the commercial development of LP-10. LP-10 is a liposomal tacrolimus formulation for local (topical) intravesical administration to the… more
Abstract:DESCRIPTION (provided by applicant): Lipella Pharmaceuticals Inc. (Pittsburgh, PA) is a clinical-stage pharmaceutical company specializing in intravesical therapies for urinary bladder dysfunctions. Lipella is submitting a research proposal to the Small Business Technology Transfer program titled … more
Abstract:Missile modernization and future missile designs are utilizing more sophisticated and higher powered electronics in the pursuit of extended missile range, improved accuracy and precision targeting for striking enemy threats. Tight packaging and sophistication of these electronic systems can generate… more
Abstract:Advanced composite material systems are vital to the development of lightweight, multi-functional Army missile systems. In addition to reducing the weight of the structure, composite materials provide the ability to expand the function of the structure by tailoring stiffness and strength… more
Abstract:Efficient use of two-dimensional (2D) and three-dimensional (3D) woven carbon-carbon (C/C) composite materials used in many thermal protection applications requires that onset and development of material non-linearity be accounted for during design. The theoretical framework and computational… more
Abstract:The current welded aluminum ramps on the Navy"s Landing Craft Air Cushion (LCAC) hovercraft are prone to damage related to extreme vehicle and seaway load requirements in combination with corrosion and erosion due to the harsh salt-laden marine environment in which they operate. Improving… more
Abstract:ABSTRACT: Development and use of new composite materials is imperative for continued advancement of airframe and engine systems. In order to facilitate the accelerated insertion of new composite materials, there is a need for an improved analysis methodology that allows designers to reduce the… more
Composite materials often represent the most weight efficient and lowest cost solutions for airframe structures. Many of these structures are in areas that are susceptible to incidental impact damage and require adequate residual strength after impact for specified periods of service. … more
Abstract:In this proposal, Materials Sciences Corporation (MSC) and its manufacturing partner Seemann Composites Inc. (SCI) have defined several synergistic material science innovations that have the potential to lower the cost, or increase the performance at the current cost, of surface combatant sonar… more
Abstract:Among the factors that inhibit the use of composite materials in both general aviation aircraft and DoD platforms are the relatively high cost of engineering and certification. Unless manufacturers control risk when introducing new or advanced materials and processes for aircraft, the potential… more
Abstract:Advanced Navy reentry vehicles will use 2D and 3D carbon-carbon (CC) thermal protection system (TPS) components in order to survive conditions imposed by high speed flight. The TPS structures are exposed to severe temperatures, pressures and thermal gradients that the designer must address to… more
Abstract:ABSTRACT: The Arnold Engineering Development Complex (AEDC) represents the nation"s largest aerospace ground test facilities and includes several wind tunnels that are unlike any other in the world. AEDC routinely provides aerodynamic and aerothermodynamic ground testing to evaluate… more
Abstract:The Navy has established a need to update the battery capability of the present Active Source sonobuoy used in Anti Submarine Warfare(ASW) systems. The technology which is currently deployed achieves up to 14, 10 second pulses providing 2400 watts of power at 75 volts. The present battery, a primary… more
Abstract:Present Sonobuoy and Unmanned Aerial Vehicle (UAV) fleets being developed by the US NAVY for Anti-Submarine Warfare(ASW) systems rely upon electrochemical energy storage for primary power. The increase in instrumentation payloads and mission duration has increased the draw on existing energy sources… more
Abstract:MaxPower Inc. is proposing the development of an energy dense lithium reserve battery for air-to-surface missile applications based on their missile operational environment validated Lithium/Vanadium Pentoxide technology. The basis of the effort is the reserve battery designed to meet the… more
Abstract:MaxPower incorporated is dedicated to the continued development of a high power battery utilizing a novel cell design coupled with a rate capable cathode formulation based upon a primary Lithium/Vanadium Pentoxide chemistry. Originally developed as a safe alternative to the 42 cell, Li/SO2 battery… more
Abstract:DESCRIPTION (provided by applicant): Production of histone modifying enzymes and identification of chemical probes for epigenetic discovery Genomic function is the major factor in the most common diseases. Genomic function is regulated by the posttranslational methylation and acetylation state of… more
Abstract:To capture critical weather and SST data in the Tropical Cyclone Boundary Layer (TCBL), Piasecki Aircraft proposes to evaluate existing meteorological sensor packages, integrate new off-the-shelf MEMS sensors, and design an air-launched UAS to improve the resolution of observations captured in the… more
Abstract:Piasecki Aircraft Corporation (PiAC) proposes to develop an innovative cargo floor of Aluminum Isogrid construction that maintains durability while cutting the weight by a third from 1500lb to 1030lb. This design cuts floor panel numbers from 54 to 24, resulting in reduced maintenance labor. The… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will finalize the Grip-Act-Reposition (GAR) Miniaturized Stable Working Platform for Minimally Invasive Procedures Inside Active Organs - with initial focus on treating Atrial Fibrillation (AF). A common procedure for treating AF is… more
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