Abstract:The innovation is an agent-based, data-driven guiding technology that will augment the human facility to evaluate task performance by overcoming human limitations to recall complex processes that require high expertise. The cloud-based, mobile technology will assist teams of varying expertise and… more
Abstract:This Small Business Innovation Research Phase 1 project aims to develop a device to reliably and safely close laparoscopic port sites. Laparoscopy is becoming the gold standard for all abdominal procedures. Laparoscopy requires small incisions to be made in the abdominal wall to allow access to the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes a new expression platform in Escherichia coli applicable to both drug discovery and biopharmaceutical manufacturing. It solves and leverages recombinant protein misfolding in E. coli. Small molecular weight compounds are used in… more
Abstract:DESCRIPTION: We identified the Myrica cerifera (Southern Bayberry) extract using a systematic screen as a potent reducer of the structural protein tau, which accumulates in a group of diseases called the tauopathies . The most prevalent tauopathy is Alzheimer's disease, for which there is… more
Abstract:DESCRIPTION (provided by applicant): Multiple Myeloma (MM) is a deadly plasma cell malignancy. Treatment advances have improved clinical outcomes over the past decade, but the disease remains incurable, thus creating a need for new and innovative treatmentoptions. The MM drug pipeline includes… more
Abstract:A new Field-Microphone in Real Ear (F-MIRE) Field Attenuation Estimation System (FAES) is proposed. The insertion loss measurements will utilize a sub-miniature microphone mounted deep in the ear canal. An ultra-thin flat flexible cable (FFC) will connect the microphone to the PC-based analysis… more
Abstract:Transit Agency Information required for managing Service centers on resources and assets that need to be available to operate the transit service as designed. An opportunity exists to design an Integrated Framework providing Service delivery and Maintenance Management Information to quantify the… more
Abstract:Robots need to know their location to map of their surroundings but without global positioning data they need a map to identify their surroundings and estimate their location. Simultaneous localization and mapping (SLAM) solves these dual problems at once. SLAM does not depend on any kind of… more
Abstract:Recently, the availability of the high performance rare earth based magnets (Nd-Fe-B and Sm-Co) was jeopardized due to the Chinese monopoly of rare earth production, which undermines our national security and competitiveness in the defense and clean energy sectors and creates a strategic… more
Abstract:The objective of this project is to design and develop an innovative miniature actuation system for use in a 40mm guided, extended flight, surveillance projectile. Included in the design will be a miniature control and actuation system, an on-board surveillance system, and an on-board autopilot… more
Abstract:DESCRIPTION (provided by applicant): The C-PACE Project (Communications Processes for Accountable Care Enhancement) will develop a new and innovative form of social computing that is customized for the care of frail, elderly patients. A successful C-PACE system will improve patient-centered health… more
Abstract:Looking Glass is an immersive, story-driven game experience that enables computer science education for students K-12. It presents learning in a game-based series of challenge levels that permit a high degree of player choice in tailoring educational progression and adapting game systems that… more
Abstract:DESCRIPTION (provided by applicant): Epilepsy is a serious and costly neurologic condition that affects approximately 3% of the US population, and is often both costly and difficult to diagnose. Presently, a physician's diagnosis is based on a combinationof the physician's clinical… more
Abstract:This Small Business Innovation Research Phase I project will investigate the harvesting of kinetic river energy to produce electricity using a morphing structure designed to exhibit hydroelastic gallop. Most hydroelectric harvesters require damming a river to create head, while the exceptions that… more
Abstract:The contractor shall design and implement a context independent anomaly detection (CIAD) application to provide enhanced situational awareness using intelligence, surveillance, and reconnaissance (ISR) sensors. The CIAD will provide an automated mechanism for analyzing vast amounts of data… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop Micro-Electro-Mechanical Systems (MEMS) based acoustic emission (AE) sensors for structural health monitoring. AE is a well-established nondestructive testing technique commonly used to monitor for active fatigue cracks in… more
Abstract:DESCRIPTION (provided by applicant): Falling accidents are among the largest and fastest growing sources of occupational injuries. Despite slips representing a plurality of all falling accidents, the technology used to assess the slipperiness of shoe andfloor surfaces has remained relatively… more
Abstract:DESCRIPTION (provided by applicant): This Phase 1 SBIR project is to perform go-/no-go evaluation of the proprietary protein, angiocidin, as a novel therapy for the treatment of acute myeloid leukemia (AML). AML is a significant medical burden as existingtherapy based on cytotoxic drugs has a low… more
Abstract:DESCRIPTION (provided by applicant): One of the hallmarks of type 2 diabetes (T2D) is an inadequate number of functional pancreatic beta cells that results in insufficient insulin leading to hyperglycemia. Our preliminary work using various mouse models identified a novel target, menin, which can be… more
Abstract:DESCRIPTION (provided by applicant): The proposed Phase I project will transfer gammaPNA miniprobe technology developed at Carnegie Mellon University and the University of Pittsburgh to PNA Innovations, Inc, a small business located in Pittsburgh. The basis of gammaPNA miniprobes is the high… more
Abstract:DESCRIPTION (provided by applicant): Innolign Biomedical has developed an implantable product using novel tissue engineering technologies that spatially direct vascularization and will use the product in the treatment of ischemic conditions. The goal of this Phase I STTR proposal is to establish the… more
Abstract:DESCRIPTION (provided by applicant): Innolign Biomedical has developed a novel microtissue system for assessing potential drug cardiotoxicities using technologies that allow for the creation of miniaturized human tissue constructs and the measurement theirbiomechanical activity. The goal of this… more
Abstract:DESCRIPTION (provided by applicant): SUMMARY This project aims to produce and beta-test a clinical decision support application for end- stage heart failure, titled CHRiSS: Cardiac Health Risk Stratification System. It will be designed for patients with progressive heart failure who may eventually… more
Abstract:TeleWellness Solutions for Chronic Conditions Project Summary Disability and chronic illness cost over 260B every year, including preventable hospitalizations, emergency room visits and secondary conditions such as wounds, urinary tract infections, pneumonia, and sepsis. This proposal describes a… more
Abstract:The utilization of dedicated bioenergy crops from renewable biomass resources is a goal with great relevance to current environmental and security issues on a global scale. There are significant ecological, economic and political pressures to develop liquid biofuels production (such as biodiesel,… more
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