Abstract:Intellectual Merit This Small Business Innovation Research Phase I project takes a novel approach to produce improved maize cultivars for bioenergy applications. Lignin in cellulosic biomass creates a barrier that limits conversion of cellulose into biofuels. In the proposed approach, the lignin in… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project objective is to evaluate the technical feasibility of a hand-held, point-of-care instrument for the detection of early-stage pressure ulcers. Pressure ulcers (PUS) are a common healthcare problem that affects approximately 2.3 million… more
Abstract:DESCRIPTION (provided by applicant): Targeted Therapeutic Solutions (TTS, a small business) is developing a first-in-class thromboprophylactic agent (TTS01) for use in the hospital setting having a rapid onset of action to dissolve clots and prevent the formation of new clots with a reduced risk of… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project develops a novel surgical closure system for closing internal incisions in endoscopy. The initial application is closing the vaginal cuff in laparoscopic hysterectomy. Sutures are typically used to close internal incisions in… more
Abstract:DESCRIPTION (provided by applicant): Development of a urine test for the early detection of liver cancer. The need to develop an effective method of detecting hepatocellular carcinoma (HCC) is urgent. HCC is the third leading cause of cancer deaths and hasa 5-year survival rate of less than 15%. If… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop novel high energy/power density polymer based cathode material for Li-ion battery. There is great demand for inexpensive, lightweight, and environmentally friendly Li-ion batteries for emerging applications such as… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop innovative baby food products with optimized nutritional value. The research objective is to establish optimized processing methods through mechanics-based approaches to enhance nutrient bioavailability and… more
Abstract:Elevated levels of human butyrylcholinesterase (BuChE) confer protection from chemical warfare nerve agents and other organophosphorous chemicals. As a prophylactic, the key to enabling this protection is the ability to maintain elevated concentrations of BuChE in the plasma for days or weeks. … more
Abstract:DESCRIPTION (provided by applicant): Controlled release formulations can improve patient adherence and drug safety or even enable new types of basic medical research. The key to realizing these benefits is the ability to design and produce these formulations in a cost-effectiv and timely manner.… more
Abstract:While unmanned air vehicles are starting to operate in complex urban and indoor environments, many challenges still remain. Our proposed project will address three key challenges through the development of algorithms. First, we reduce operator workload in the operation of autonomous vehicles in GPS… more
Abstract:This Small Business Innovation Research Program (SBIR) Phase I project will develop a "Fiber-loop Cavity Ring-down spectrometer" to address the critical need for an in situ means to measure contaminants in cryogenic liquids. Lacking a way to measure impurities in the liquid phase,… more
Abstract:The innovation is an agent-based, data-driven guiding technology that will augment the human facility to evaluate task performance by overcoming human limitations to recall complex processes that require high expertise. The cloud-based, mobile technology will assist teams of varying expertise and… more
Abstract:This Small Business Innovation Research Phase 1 project aims to develop a device to reliably and safely close laparoscopic port sites. Laparoscopy is becoming the gold standard for all abdominal procedures. Laparoscopy requires small incisions to be made in the abdominal wall to allow access to the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes a new expression platform in Escherichia coli applicable to both drug discovery and biopharmaceutical manufacturing. It solves and leverages recombinant protein misfolding in E. coli. Small molecular weight compounds are used in… more
Abstract:DESCRIPTION: We identified the Myrica cerifera (Southern Bayberry) extract using a systematic screen as a potent reducer of the structural protein tau, which accumulates in a group of diseases called the tauopathies . The most prevalent tauopathy is Alzheimer's disease, for which there is… more
Abstract:DESCRIPTION (provided by applicant): Multiple Myeloma (MM) is a deadly plasma cell malignancy. Treatment advances have improved clinical outcomes over the past decade, but the disease remains incurable, thus creating a need for new and innovative treatmentoptions. The MM drug pipeline includes… more
Abstract:A new Field-Microphone in Real Ear (F-MIRE) Field Attenuation Estimation System (FAES) is proposed. The insertion loss measurements will utilize a sub-miniature microphone mounted deep in the ear canal. An ultra-thin flat flexible cable (FFC) will connect the microphone to the PC-based analysis… more
Abstract:Transit Agency Information required for managing Service centers on resources and assets that need to be available to operate the transit service as designed. An opportunity exists to design an Integrated Framework providing Service delivery and Maintenance Management Information to quantify the… more
Abstract:Robots need to know their location to map of their surroundings but without global positioning data they need a map to identify their surroundings and estimate their location. Simultaneous localization and mapping (SLAM) solves these dual problems at once. SLAM does not depend on any kind of… more
Abstract:Recently, the availability of the high performance rare earth based magnets (Nd-Fe-B and Sm-Co) was jeopardized due to the Chinese monopoly of rare earth production, which undermines our national security and competitiveness in the defense and clean energy sectors and creates a strategic… more
Abstract:The objective of this project is to design and develop an innovative miniature actuation system for use in a 40mm guided, extended flight, surveillance projectile. Included in the design will be a miniature control and actuation system, an on-board surveillance system, and an on-board autopilot… more
Abstract:DESCRIPTION (provided by applicant): The C-PACE Project (Communications Processes for Accountable Care Enhancement) will develop a new and innovative form of social computing that is customized for the care of frail, elderly patients. A successful C-PACE system will improve patient-centered health… more
Abstract:Looking Glass is an immersive, story-driven game experience that enables computer science education for students K-12. It presents learning in a game-based series of challenge levels that permit a high degree of player choice in tailoring educational progression and adapting game systems that… more
Abstract:DESCRIPTION (provided by applicant): Epilepsy is a serious and costly neurologic condition that affects approximately 3% of the US population, and is often both costly and difficult to diagnose. Presently, a physician's diagnosis is based on a combinationof the physician's clinical… more
Abstract:This Small Business Innovation Research Phase I project will investigate the harvesting of kinetic river energy to produce electricity using a morphing structure designed to exhibit hydroelastic gallop. Most hydroelectric harvesters require damming a river to create head, while the exceptions that… more
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