Abstract:DESCRIPTION (provided by applicant): Calista Therapeutics has discovered a first-in-class, proprietary PDZ1-2 lead drug, AT010, that is being optimized and developed as an inhaled daily therapy for cystic fibrosis (CF). CF is a deadly inherited genetic disorder that disrupts chloride channel… more
Abstract:Propel LLC proposes to systematically investigate novel stitchless seam technologies with the potential to be used for the design and engineering of existing US Navy clothing end-items. Propel will develop sample seams using the identified stitchless technologies and use these samples to evaluate… more
Abstract:ABSTRACT: A key requirement for a practical/scalable airborne passive radar system using opportunistic ground emitters such as broadcast TV is the ability to effectively isolate the high-powered direct-path signals from much weaker target reflected ones. Previous passive radars rely on array… more
Abstract:Current monostatic radar systems suffer fine tracking and discrimination performance degradation when encountering mainlobe jammers deployed within a reentry complex. As a result our forces may be vulnerable to attack. During Phase I, we have developed distributed aperture techniques for mitigating… more
Abstract:Applied Radar, Inc. is developing the Single Channel Open Source Architecture (SCORE) digital receiver/exciter (DREX) card which represents a revolutionary step leap in SWAP-C reduction. The SCORE card is a 3U OpenVPX card which incorporates a single channel of waveform generation, RF Upconversion,… more
Abstract:The proposal will develop multiple design concepts, conduct a trade study, and identify the three (3) most promising concepts for affordable low-profile and wideband satellite communication antennas (LPWSA) with high data rate capability and minimum airstream protrusion for airborne platforms. … more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase II project is to advance the development of novel tolerance-inducing peptides (Tregitopes) to prevent and/or treat Type 1 diabetes (T1D) by optimizing the clinical delivery vehicle and treatment protocol, and by identifying correlates of… more
Abstract:DESCRIPTION (provided by applicant): Inducing Tolerance to Enzyme Replacement Therapy for Pompe Disease Pompe disease is a lysosomal storage disorder caused by defects in the enzyme acid alpha-glucosidase (GAA) that leads to glycogen accumulation affectingheart and skeletal muscle.… more
Abstract:DESCRIPTION (provided by applicant): The goal of this new SBIR program is to produce a combined clotting Factor VIII replacement and immunomodulatory therapy that will provide FVIII-specific tolerance induction at therapeutic doses for Hemophilia A patients. Hemophiliacs with lt 1% functional FVIII… more
Abstract:DBV Technology, LLC proposes to design, build, integrate and test an array of undersea acoustic instruments capable of scoring multiple projectiles impacting the ocean surface closely spaced in both position and time using algorithms developed during Phase I. A 48 month period of performance is… more
Abstract:DESCRIPTION (provided by applicant). Several leading authorities, including the World Health Organization (WHO) and the U.S. Department of Health and Human Services (DHHS), have identified asthma as a priority disease area, and have called for action to reduce chronic disability and premature death… more
Abstract:DESCRIPTION (provided by applicant): Researchers and contractors are under increasing pressure to produce rapid turnaround times for data releases and publications. Inadequate data management is a common threat to good research and impedes the quick release of high value data. Despite its importance… more
Abstract:DESCRIPTION (provided by applicant): Excessive alcohol use is associated with a range of serious and costly health, social, and economic consequences at the individual and societal level. This program of research serves as a venue by which to produce and test an innovative, science-based, and… more
Abstract:DESCRIPTION (provided by applicant): Juvenile crime imposes enormous costs on victims, on society, and on juvenile offenders themselves. However, research assessing the efficacy of interventions for young offenders show, on average, only small effects on recidivism, substance abuse, and other… more
Abstract:DESCRIPTION (provided by applicant): The primary goal of this proposed research is to develop a rapid point-of-care (POC) test that can be used to identify neonatal sepsis in high-risk infants in a simple, user-friendly and portable device suitable for usein the NICU setting. Since sepsis presents a… more
Abstract:US Navy submarine forces currently employ an independent team to test, measure, calibrate and certify radio frequency (RF) signal paths through sail mounted antennae to the inboard radio rooms in a process that can take in excess of 60 man-days to complete. Ships personnel have no means of… more
Abstract:This effort to improve the capabilities of the ESM system will increase the reliability and reduce lifecycle support costs of the Radar Wideband (RWB) subsystem on submarines. Analog to digital converter (A/D) based digital receivers will be applied to yield improvements in Radar signal acquisition… more
Abstract:Since the advent of impulse launching various payloads from Navy and other military combatants, the source of the impulse energy has been either an explosive gas generator (propellant) or stored high pressure gas in a flask. Both of these methods have high maintenance and/or clean-up costs and are… more
Abstract:The objective of this Phase 1 effort is to develop an asymmetric supercapacitor (ASC) that provides>10 Wh/kg energy density and a high power density, and maintains this performance down to -55 degrees C. Yardney Technical Products (YTP), a recognized specialty high energy battery manufacturer in… more
Abstract:The objective of this proposal is to develop a high-energy and high-power hybrid system consisting of a lithium ion (Li-ion) battery in conjunction with an ultracapacitor (UCAP) for advanced power storage systems for interceptors. Yardney Technical Products (YTP), the world leader in cutting-edge… more
Abstract:Yardney Technical Products in conjunction with Johns Hopkins University Applied Physics Laboratory is proposing to progress development of an advanced monitoring system for batteries, provide a modular battery unit, and develop a system approach to monitor and control multiple power sources and… more
Abstract:Yardney Technical Products, Inc., with SBIR partners, Brown University and Fraunhofer LLC, propose to develop a high energy density, high power, bipolar battery. Bipolar battery designs are inherently the most volumetrically efficient batteries. Further, the elimination of the external intercell… more
Abstract:The goal of this project is to take silver-zinc battery technology to a new level for programs important to the Navy. Silver-Zinc batteries provide high energy and power density cells, and since the electrolyte is a water-based alkaline fluid, provide a comparatively safe battery. A disadvantage to… more
Abstract:ABSTRACT: Multi-sensor fusion is a key capability required for effective inferences for timely and accurate strategy and tactical planning. A multi-sensor fusion technology needs to appropriately weigh different image streams according to the uncertainties and errors across different inputs and… more
Abstract:Missile threats faced by our country are constantly increasing in lethality. The weapon used to counter such missiles is the kinetic interceptor. To work effectively, the reentry vehicle (RV) location must be precisely known. Confusing objects within the reentry complex make the key discrimination… more
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