Abstract:Our missile defense capability crucially depends on radar performance to detect, track and discriminate hostile targets. New radar designs being developed offer enhanced capability. However, a significant impediment to the deployment of these new radars is the high cost of active electronically… more
Abstract:DESCRIPTION (provided by applicant): BCR Diagnostics, Inc. (BCR) has recently developed and patented a technology platform for engineering fluorogenic functionality into living Bacillus spores. Fluorogenic spores (F-spores) produced at
BCR appear to be physiologically identical… more
Abstract:We propose a compact broadband underwater cylindrical transducer with directional capabilities for acoustic communications (ACOMMS) for unmanned underwater vehicles (UUVs) and gliders. Our proposed solution is to incorporate single crystals and directional capabilities into the acoustic modem… more
Abstract:We propose a compact broadband underwater cylindrical transducer with integrated power amplifier for multiple applications, including acoustic communications (ACOMMS) for unmanned underwater vehicles (UUVs) and gliders. Such compact, modular devices could be used alone or arranged into various array… more
Abstract:This proposal is for the design and development of a new low cost directional acoustic sensor technology with integrated acoustic modem capabilities for distributed sensor systems. The study addresses the feasibility to significant improve legacy performance of current A-size directional sonobuoy… more
Abstract:The objective of this program is to demonstrate and miniaturize a new type of cryogenic expander, thermoacoustic expander (TAE), for space cryocoolers which provide the cooling power less than 50 mW and operate in the low temperature range between 40K and 10K for cooling SWIR, MWIR, and LWIR… more
Abstract:A "Small Buoy for Energy Harvesting" has applications for use on current and future buoy systems used by the submarine fleet of the United States Navy. This work proposes to meet the requirements by converting mechanical wave energy to electrical energy using a generation system housed in a spar… more
Abstract:DESCRIPTION (provided by applicant): This new Phase I SBIR proposal addresses the continuing worldwide need for a tuberculosis (TB) vaccine. We detail a novel multivalent strategy that aims to elicit immunity to prevent reactivation of latent TB. This epit
ope-driven, DNA-prime, protein-boost TB… more
Abstract:DESCRIPTION (provided by applicant): Hemophilia A patients are prone to develop inhibitory immune responses to the very therapy they require: Factor VIII protein replacement. Up to 30% of all hemophiliacs and greater than 50% of severe hemophiliacs produce
antibodies (inhibitors) in response to… more
Abstract:This SBIR Phase I proposal requests $99739 for Flight Safety Technologies, Inc. to investigate the feasibility and all-weather capability of a novel radar concept as an active, non-cooperative SAA sensor for UAVs. The concept radar, which we call Unicorn, is a narrow-band pulsed radar operating… more
Abstract:We propose to develop a means of combining unit-level and entity-level combat simulations that combines the best features of both and avoids the problems and overhead of multi-resolution simulations and inter-level interactions. The essential idea, which will be elaborated in the following sections… more
Abstract:Yb double clad lasers are the "work horse" of high power systems. By codoping with Sm to quench stimulated emission at 1,070 nm (4 level system), Yb/Sm can be forced to lase efficiently at 980 nm. By further using HOM (Higher Order Mode) fiber design, greater energy storage/length can be achieved,… more
Abstract:KVH Industries plans to take advantage of the work performed in Phase I, as well as some extensive internally-funded R&D, to create an affordable, accurate, FOG-based Northfinder. The Phase II approach entails designing a true null seeking servo driven system, using a highly accurate single-axis FOG… more
Abstract:DESCRIPTION (provided by applicant): SBIR Abstract for DATACORP's Data Documentation Database (D3) Data documentation is an intricate and time-consuming task. Practical experience has shown that research studies frequently save time and financial costs by
delegating the task to less experienced… more
Abstract:DESCRIPTION (provided by applicant): Myomics' drug screening technology to be developed in this Phase 1 SBIR project for Duchene muscular dystrophy (DMD) is based upon an in vitro skeletal muscle tissue force measurement technique for high content screenin
g (HCS) of compounds to attenuate muscle… more
Abstract:This Small Business Innovation Research (SBIR) Phase II research develops an innovative high-throughput/high content drug screening platform that utilizes three-dimensional human skeletal muscle tissue constructs that mimic in vivo skeletal muscle to quantify muscle force generation. Significant… more
Abstract:DESCRIPTION (provided by applicant): The rationales for the development of technology that will enable extremely cheap, high speed sequencing are well established. Chief among these is the enablement of personalized medicine. There are currently in develop
ment several technologies that promise to… more
Abstract:DESCRIPTION (provided by applicant): Low birthweight and preterm birth are unfavorable birth outcomes that translate into serious and costly health issues, including infant morbidity and infant mortality. Research demonstrates that the health behaviors of
pregnant women are associated with not only… more
Abstract:DESCRIPTION (provided by applicant): Plasma fractionation is one of the largest industry segments in global therapeutic protein manufacture. The United States plays an important role in this industry since it represents the largest plasma collection and ma
nufacturing base that accounts for more… more
Abstract:DESCRIPTION (provided by applicant): Development of a Functional Health CAT for Managing Obesity Abstract In recent decades the prevalence of obesity has increased dramatically in the United States, causing a great burden for the individual and society. Al
though behavioral factors are among the… more
Abstract:DESCRIPTION (provided by applicant): With improvements in the survival of patients with HIV and AIDS, maximizing patients' functional status and well-being is increasingly an important treatment goal. Existing instruments for assessing HIV patients' self-
reported functional status and well-being… more
Abstract:DESCRIPTION (provided by applicant): Several recent initiatives have emphasized the importance of developing and testing new technologies to measure patient-reported outcomes (PRO). PRO measures for asthma can be substantially improved using item response
theory (IRT), and competing objectives of… more
Abstract:Mass spectrometry is a technology with wide-ranging applications in defense and homeland security. The technique is widely applicable and exceedingly sensitive, but for many molecules there can be ambiguities regarding the isomeric and conformeric form. As the number of atoms in a molecule… more
Abstract:Current shipboard emergency flow control devices for fluid systems use either pneumatic power or electric motors to close valves when a rupture is detected. These systems are dependent on the availability of the electric power or low pressure air systems. In a casualty situation, these support… more
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