Abstract:DESCRIPTION (provided by applicant): Several recent initiatives have emphasized the importance of developing and testing new technologies to measure patient-reported outcomes (PRO). PRO measures for asthma can be substantially improved using item response
theory (IRT), and competing objectives of… more
Abstract:Mass spectrometry is a technology with wide-ranging applications in defense and homeland security. The technique is widely applicable and exceedingly sensitive, but for many molecules there can be ambiguities regarding the isomeric and conformeric form. As the number of atoms in a molecule… more
Abstract:Current shipboard emergency flow control devices for fluid systems use either pneumatic power or electric motors to close valves when a rupture is detected. These systems are dependent on the availability of the electric power or low pressure air systems. In a casualty situation, these support… more
Abstract:Present sonobuoys require manual selection and verification of functions such as RF Channel, Depth, etc. with selection and verification impossible while the sonobuoys are loaded in the launcher or in the storage racks onboard. The capability to select and verify functions while the sonobuoys are… more
Abstract:DESCRIPTION (provided by applicant): Cell Cures' technology utilizes easily isolated and well characterized adult human skeletal muscle stem cells (satellite cells or myoblasts). These striated muscle progenitor cells provide an expandable source of prolif
erating cells which have already been… more
Abstract:The overall objective of this effort is to address a nagging void in the study of Information Age Warfare: there is no coherent set of tools that military analysts can use to visualize, measure, understand and asses networked military systems. While there has been a great deal of effort expended to… more
Abstract:New missions require that airborne radars operate at increasing ranges with higher target resolution. This combination necessitates the cost-effective deployment of large apertures while maintaining aerodynamic performance. Externally mounted antenna arrays are not a satisfactory solution due to the… more
Abstract:The objective of the proposed effort is to develop a digital beamforming (DBF) processor capable of generating multiple simultaneous receive beams with a wide (>500 MHz) instantaneous bandwidth (IBW). This would offer a significant improvement over a similar DBF processor with 15 MHz IBW that… more
Abstract:The proposed Phase II project is to provide an advanced operational waterborne transport modeling capability of chemical agents within four-dimensional marine and fresh water environments. Based upon the findings of Phase I, we propose to further enhance the operational capabilities of ASA's… more
Abstract:Existing near-field calibration methods for cylindrical MF and HF bow arrays are not easily applied to combatant ships with complex hull forms. The objective of this proposed project is to develop and deliver a cost effective in-situ system for providing sonar transducer acoustic calibration and… more
Abstract:FarSounder proposes to develop a low cost 3D sonar system for underwater threat detection. This system will be based on the FarSounder 3D sonar technology and will utilize COTS components which will leverage FarSounder`s advanced processing techniques to increase the system`s performance when… more
Abstract:Marine Acoustics, Inc., will design and develop a sonar screening, detection, and classification system using a MATLAB-based format. Existing software components such as a cepstrum-based screener and a wavelet-based signal processing algorithm, as well as new components to be designed, will be… more
Abstract:DESCRIPTION (provided by applicant): Insulin-dependent diabetes mellitus is an autoimmune disease characterized by T cell attack of pancreatic islet cells leading to irreversible loss of the insulin secreting cells. One potential strategy for combatting the autoimmune process involves the… more
Abstract:The Small Business Innovation Research (SBIR) Phase I project will develop an innovative high-throughput/ high content drug screening platform utilizing three-dimensional human skeletal muscle tissue constructs which mimic in vivo skeletal muscle to quantify muscle force generation. The proposed… more
Abstract:DESCRIPTION (provided by applicant): Myomics? technology to be developed in this Phase 1 project is based upon an in vitro skeletal muscle tissue force measurement technique for high throughput screening (HTS) of compounds to attenuate muscle weakness. The technology, termed Patterned… more
Abstract:DESCRIPTION (provided by applicant): The U.S. Surgeon General and the U.S. Department of Health and Human Services identified heavy drinking among college students as a major public health problem. Existing interventions generally provide alcohol education focusing on skills building, rather than… more
Abstract:DESCRIPTION (provided by applicant): The primary goal of this proposal is to demonstrate the feasibility of utilizing Inter-alpha Inhibitor proteins (lalp) as an effective protective agent against exposure to anthrax, a lethal biological warfare agent. Inter-alpha inhibitor proteins are natural… more
Abstract:DESCRIPTION (provided by applicant): Experts in the treatment of depression have emphasized the importance of striving for remission. Studies have shown that depressed patients who respond to treatment but do not achieve remission, currently defined as a lack of symptoms, continue to experience… more
Abstract:DESCRIPTION (provided by applicant): We propose to apply item response theory (IRT) and computerized adaptive testing (CAT) to achieve major advances in the standardization of Chronic Kidney Disease (CKD) health-related quality of life (HRQOL) metrics, in the efficiency of data collection and… more
Abstract:DESCRIPTION (provided by applicant): We propose a tool for evaluating the functional impact of headaches that uses computerized adaptive testing (CAT) to achieve more practical and more precise assessments by matching the questions to each patient's headache severity level. In previous work, we… more
Abstract:DESCRIPTION (provided by applicant): Mental disorders are among the most prevalent conditions in the United States, and their burden for the individual and the society is tremendous. Nevertheless, they are still widely under-diagnosed in community based health care systems. One way to help general… more
Abstract:DESCRIPTION (provided by applicant): Our objective is to achieve a major advance in the technology used to assess patient reported outcomes in heart failure (HF). Numerous questionnaires currently are being used to measure outcomes of HF patients, but scores from these instruments can not be… more
Abstract:Present sonobuoys allow for the selection of functions such as RF Channel, Depth, etc. by use of a single selector button and LED display along with a second button used for verification located on the side of the sonobuoy. Selection or verification requires access to the buttons and cannot be… more
Abstract:75336S A broad category of experiments in astro-particle and high energy physics requires the construction of ultra-high-purity and ultra-low-radioactive-background, cubic-meter-scale vessels to be used as containers for ionization and scintillation media. Double-beta decay experiments, solar… more
Abstract:Applied Radar Inc. proposes the development of active MMIC-based circulators in order to achieve high isolation between transmit and receive paths for simultaneous transmit and receive (STAR) phased-array radar system architectures. This technology will enable increased persistence in intelligence,… more
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