Abstract:DESCRIPTION (provided by applicant): Hemophilia A patients are prone to develop inhibitory immune responses to the very therapy they require: Factor VIII protein replacement. Up to 30% of all hemophiliacs and greater than 50% of severe hemophiliacs produce
antibodies (inhibitors) in response to… more
Abstract:This SBIR Phase I proposal requests $99739 for Flight Safety Technologies, Inc. to investigate the feasibility and all-weather capability of a novel radar concept as an active, non-cooperative SAA sensor for UAVs. The concept radar, which we call Unicorn, is a narrow-band pulsed radar operating… more
Abstract:We propose to develop a means of combining unit-level and entity-level combat simulations that combines the best features of both and avoids the problems and overhead of multi-resolution simulations and inter-level interactions. The essential idea, which will be elaborated in the following sections… more
Abstract:Yb double clad lasers are the "work horse" of high power systems. By codoping with Sm to quench stimulated emission at 1,070 nm (4 level system), Yb/Sm can be forced to lase efficiently at 980 nm. By further using HOM (Higher Order Mode) fiber design, greater energy storage/length can be achieved,… more
Abstract:KVH Industries plans to take advantage of the work performed in Phase I, as well as some extensive internally-funded R&D, to create an affordable, accurate, FOG-based Northfinder. The Phase II approach entails designing a true null seeking servo driven system, using a highly accurate single-axis FOG… more
Abstract:DESCRIPTION (provided by applicant): SBIR Abstract for DATACORP's Data Documentation Database (D3) Data documentation is an intricate and time-consuming task. Practical experience has shown that research studies frequently save time and financial costs by
delegating the task to less experienced… more
Abstract:DESCRIPTION (provided by applicant): Myomics' drug screening technology to be developed in this Phase 1 SBIR project for Duchene muscular dystrophy (DMD) is based upon an in vitro skeletal muscle tissue force measurement technique for high content screenin
g (HCS) of compounds to attenuate muscle… more
Abstract:This Small Business Innovation Research (SBIR) Phase II research develops an innovative high-throughput/high content drug screening platform that utilizes three-dimensional human skeletal muscle tissue constructs that mimic in vivo skeletal muscle to quantify muscle force generation. Significant… more
Abstract:DESCRIPTION (provided by applicant): The rationales for the development of technology that will enable extremely cheap, high speed sequencing are well established. Chief among these is the enablement of personalized medicine. There are currently in develop
ment several technologies that promise to… more
Abstract:DESCRIPTION (provided by applicant): Low birthweight and preterm birth are unfavorable birth outcomes that translate into serious and costly health issues, including infant morbidity and infant mortality. Research demonstrates that the health behaviors of
pregnant women are associated with not only… more
Abstract:DESCRIPTION (provided by applicant): Plasma fractionation is one of the largest industry segments in global therapeutic protein manufacture. The United States plays an important role in this industry since it represents the largest plasma collection and ma
nufacturing base that accounts for more… more
Abstract:DESCRIPTION (provided by applicant): Development of a Functional Health CAT for Managing Obesity Abstract In recent decades the prevalence of obesity has increased dramatically in the United States, causing a great burden for the individual and society. Al
though behavioral factors are among the… more
Abstract:DESCRIPTION (provided by applicant): With improvements in the survival of patients with HIV and AIDS, maximizing patients' functional status and well-being is increasingly an important treatment goal. Existing instruments for assessing HIV patients' self-
reported functional status and well-being… more
Abstract:DESCRIPTION (provided by applicant): Several recent initiatives have emphasized the importance of developing and testing new technologies to measure patient-reported outcomes (PRO). PRO measures for asthma can be substantially improved using item response
theory (IRT), and competing objectives of… more
Abstract:Mass spectrometry is a technology with wide-ranging applications in defense and homeland security. The technique is widely applicable and exceedingly sensitive, but for many molecules there can be ambiguities regarding the isomeric and conformeric form. As the number of atoms in a molecule… more
Abstract:Current shipboard emergency flow control devices for fluid systems use either pneumatic power or electric motors to close valves when a rupture is detected. These systems are dependent on the availability of the electric power or low pressure air systems. In a casualty situation, these support… more
Abstract:Present sonobuoys require manual selection and verification of functions such as RF Channel, Depth, etc. with selection and verification impossible while the sonobuoys are loaded in the launcher or in the storage racks onboard. The capability to select and verify functions while the sonobuoys are… more
Abstract:Lithium-ion (Li-ion) batteries are attractive candidates for use as power sources in military, aerospace, commercial, and vehicular applications because they have high specific energy (up to 200 Wh/kg) and energy density (~ 500 Wh/L) and long cycle life (1,000 - 80,000 cycles currently depending on… more
Abstract:The objective of this proposal is to demonstrate the feasibility of producing a novel nano-engineered anode material that significantly shortens the Li+ diffusion length and enable lithium ion batteries capable of being quickly recharged in less than 15 minutes. A nanostructured electrode will be… more
Abstract:Many missions in remote locations are currently limited by the amount of power that can be carried on foot and/or left in place for unattended equipment operation. To solve the soldier's battery weight burden, advanced metal-air batteries are being developed. The monitoring of the effective battery… more
Abstract:This Small Business Innovation Research Phase I project will advance an efficient and lightweight energy storage device for Unmanned Air Vehicles (UAV) by developing a high energy density lithium-air cell with a radical new design. Specifically, the project advances high energy density cells by… more
Abstract:One of the problems with Li-ion technology is its somewhat limited ability to charge at high rates. At high charge rates lithium plating on the negative electrode can occur, which will hurt cycle life and could present safety risks. There is a need within the Army, Navy, other military services,… more
Abstract:One of the major challenges of developing aircraft is the development of an appropriate energy system. The energy system ideally has a large amount of energy with a very low weight. This equates to a high specific energy (Wh/kg). Lithium-air batteries offer the greatest theoretical specific energy… more
Abstract:This project will develop inexpensive and environmentally benign LiMnPO4 cathodes for applications to lithium-ion batteries (LIB) used in electric and hybrid electric vehicles. This cathode material is expected to be far safer than Li-ion batteries employing traditional layered LiMO2 (M=Co, Ni)… more
Abstract:Lithium-ion batteries are promising energy storage devices for hybrid and electric vehicles, providing high specific energy (approximately 150 Wh/kg), energy density (approximately 400 Wh/L), and long cycle life (greater than 15 years). However, these applications require further increases in… more
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