Abstract:DESCRIPTION (provided by applicant): We propose to apply item response theory (IRT) and computerized adaptive testing (CAT) to achieve major advances in the standardization of Chronic Kidney Disease (CKD) health-related quality of life (HRQOL) metrics, in the efficiency of data collection and… more
Abstract:DESCRIPTION (provided by applicant): We propose a tool for evaluating the functional impact of headaches that uses computerized adaptive testing (CAT) to achieve more practical and more precise assessments by matching the questions to each patient's headache severity level. In previous work, we… more
Abstract:DESCRIPTION (provided by applicant): Mental disorders are among the most prevalent conditions in the United States, and their burden for the individual and the society is tremendous. Nevertheless, they are still widely under-diagnosed in community based health care systems. One way to help general… more
Abstract:DESCRIPTION (provided by applicant): Our objective is to achieve a major advance in the technology used to assess patient reported outcomes in heart failure (HF). Numerous questionnaires currently are being used to measure outcomes of HF patients, but scores from these instruments can not be… more
Abstract:Present sonobuoys allow for the selection of functions such as RF Channel, Depth, etc. by use of a single selector button and LED display along with a second button used for verification located on the side of the sonobuoy. Selection or verification requires access to the buttons and cannot be… more
Abstract:Some of the challenges of manufacturing batteries for military applications are: low quantities, sporadic demand, high price and various power sources. If a Multi-Functional Cell Case for Metal-Air Batteries, such as Lithium-Air, Aluminum-Air, and Zinc-Air could be created, then it would be possible… more
Abstract:Lithium-ion (Li-ion) batteries are attractive candidates for use as power sources in aerospace applications because they have high specific energy ( up to 200 Wh/kg) and energy density ( 500 Wh/L) and long cycle life (1,000 ? 30,000 cycles currently depending on the depth of cycling). However, at… more
Abstract:This SBIR Phase I effort will be to construct and evaluate a high specific energy and high power lithium-air/ lithium-ion hybrid battery system. One of the challenges of incorporating metal-air batteries into existing equipment is the power requirements. Metal-air systems are typically very high in… more
Abstract:Lithium-ion batteries have been widely used and intensely investigated for the last decade. However, commercial cells have several problems including loss of power and capacity upon storage or prolonged use at elevated temperatures. In order to develop high-energy power sources for Army… more
Abstract:75336S A broad category of experiments in astro-particle and high energy physics requires the construction of ultra-high-purity and ultra-low-radioactive-background, cubic-meter-scale vessels to be used as containers for ionization and scintillation media. Double-beta decay experiments, solar… more
Abstract:Applied Radar Inc. proposes the development of active MMIC-based circulators in order to achieve high isolation between transmit and receive paths for simultaneous transmit and receive (STAR) phased-array radar system architectures. This technology will enable increased persistence in intelligence,… more
Abstract:Applied Radar proposes to investigate a new method of incorporating microwave antenna and feed components directly into airframe structural members. This method is based on the 3-D weaving of a resin transfer molded (RTM) fiber reinforcement preform that meets both RF and structural requirements.… more
Abstract:The Defense Threat Reduction Agency has expressed the need for waterborne transport and dispersion capability to compliment its existing models for Chemical, Biological, Radiological and Nuclear (CBRN) releases. DTRA's current capability is limited to the atmospheric transport of CBRN agents using… more
Abstract:This project is the development of a single crystal underwater acoustic modem transducer for Unmanned Underwater Vehicles (UUV) which is compact in size, operates at low to moderately low center frequencies, in a broad band frequency range to accommodate state-of-the-art binary, FSK and spread… more
Abstract:DESCRIPTION (provided by applicant): EpiVax discovers and develops epitqpe-driven vaccines by screening microbial genomes for protective epitopes. In this application, we describe a genome-based approach for the development of a therapeutic vaccine against Helicobacter pylori disease. First, the H.… more
Abstract:DESCRIPTION (provided by applicant): EpiVax specializes in the development of epitope-driven vaccines by screening whole genomes for candidate vaccine components. In this application, we propose to develop a safe, new smallpox vaccine based on epitopes conserved between the vaccinia virus (VV) and… more
Abstract:FarSounder proposes to develop a low cost 3D sonar system for underwater threat detection. This system will be based on the FarSounder 3D sonar technology and will utilize COTS components which will leverage FarSounder`s advanced processing techniques to increase the system`s performance when… more
Abstract:Trait improvement of turfgrass through genetic engineering is important to the turfgrass industry and the environment. However, the possibility of transgene escape to wild and non-transformed species raises commercial and ecological concerns. The purpose of this project is to determine the… more
Abstract:In the proposed Phase I effort, KVH Industries will develop an Electronic Pointing Device (EPD) by implementing Northfinding software in its TG6000 Inertial Measurement Unit(IMU) product that is substantially smaller than the existing solution. Specifically, KVH will build three modified coils into… more
Abstract:Underwater acoustic modeling plays an essential role in the design, development, test, and operation of sonar systems. Active acoustic clutter can increase the sonar false alert rate or equivalently decrease the probability of detection/classification, and is a key issue in the development and… more
Abstract:DESCRIPTION (provided by applicant):
Sepsis is the systematic and overwhelming response to infection. Once triggered, an uncontrolled cascade of coagulation, impaired fibrinolysis, and inflammation drive disease progression. This results in damage to the lungs, liver, kidney and cardiovascular… more
Abstract:DESCRIPTION (provided by applicant): Obesity is recognized as a major public health concern and has become a national health priority. With the prevalence of adolescent obesity nearly triple what it was two decades ago, effective interventions to prevent and treat overweight and obesity among… more
Abstract:DESCRIPTION (provided by applicant): Unhealthy eating, lack of exercise, and poor stress management habits are started in adolescence and have been shown to initiate or promote chronic diseases. Well-designed health promotion programs are needed to assist college students in shaping a foundation of… more
Abstract:DESCRIPTION (provided by applicant): Male-to-female intimate partner violence accounts for 26% of violence-related injuries in women presenting in hospital emergency departments and 30% of all female homicides. Early to mid-adolescence provides an excellen
t window of opportunity for the… more
Abstract:DESCRIPTION (provided by applicant) The overall goal is to develop a marketable novel predictive marker based on inter-alpha inhibitor proteins (laIp) in cerebrospinal fluid (CSF) that can be utilized in the management of CNS cancer. Cost effective care, successful palliation of symptoms and new… more
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