Abstract:DESCRIPTION (provided by applicant): As cancer is one of the leading causes of death in the United States with some sub-types remaining essentially untreatable, expansion of available drug targets will provide significant new options for the development ofmore effective antineoplastic agents. The… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this project is to identify and validate biomarkers of mitochondrial dysfunction due to environmental stressors. Diverse acute insults from surgery, trauma, ischemia/reperfusion (I/R) and drug andenvironmental chemical toxicity lead to… more
Abstract:DESCRIPTION (provided by applicant): Resurfacing of articular cartilage with cold stored osteochondral allografts is employed clinically for repair of trauma and osteoarthritis-induced articular cartilage surface damage. Chondrocyte viability of transplanted articular cartilage is accepted as one of… more
Abstract:ABSTRACT Obesity is a major global health issue. According to a recent report in the Journal of the American Medical Association non-Hispanic blacks have the highest age-adjusted rates of obesity (49.5%) compared with Mexican Americans (40.4%), all Hispanics (39.1%) and non-Hispanic whites (34.3%).… more
Abstract:DESCRIPTION (provided by applicant): NMR is arguably the most powerful analytical technique for structure determination and function elucidation in molecules of all types, though the challenges are greater for biological macromolecules. Dynamic Nuclear Polarization (DNP) with Magic Angle Spinning… more
Abstract:This proposal presents a method and technology for continuous ionization of bio-aerosols and airborne particles in building protection applications to enable effective removal of the ionized particles from the air flow by an electrostatic collection device. The proposed ionization method is based on… more
Abstract:There is a Global Safeguards need for tamper-indicating coatings of varying complexity for use in the verification and authentication of nuclear security documents, materials, and equipment; however, current commercial coatings for anti-tampering seals lack the sophistication necessary for quick,… more
Abstract:This Small Business Innovation Research Phase II project will determine the technical feasibility and the commercial value proposition for high temperature, highly processable fiber optic coatings across a range of markets to include fiber lasers, fibers for oil and gas, avionics fiber, and medical… more
Abstract:ABSTRACT: We propose to develop novel high-temperature robust control ICs compatible with power SiC device using on insulated gate III-Nitride transistors MISHFETs - over SiC native nitride substrate. SET Inc patented GaN MISHFET technology offers radical device performance improvement over SiC… more
Abstract:DESCRIPTION (provided by applicant): Heart attacks (i.e. myocardial infarction or MI) occur in more than 1.2 million patients annually. Advances in pharmacological therapy have dramatically improved survival following the initial MI. Consequently, the number of patients with previous MI continues to… more
Abstract:The innovation is a novel Science, Technology, Engineering, and Math (STEM) science experimentation tool. This sensor-based tool is a smart and collaborative system that will offer a friendly introduction to science experiments for elementary aged children. The system will be developed as a… more
Abstract:This natural organic retention project proposes using lignin from emerging biorefineries to allow borates to be used as wood preservatives for exterior applications exposed to rain. Enhancing retention of environmentally-friendly borates has been the“holy grail” of the industry for decades. We… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is to establish the foundation for developing a computation-assisted redistricting product. Redistricting or zoning is the process of dividing space into districts or zones while optimizing a set of criteria under various spatial… more
Abstract:50/50 Nylon/Cotton (NyCo) fabric is currently used for many standard issue combat uniforms, such as the Marine Corps Combat Utility Uniform (MCCUU) and the equivalent ACU/ABU equivalents in other DoD services. While 50/50 NyCo fabrics are proven performers in combat uniforms and are a relatively… more
Abstract:Vaccines are the most effective therapeutic tools in preventing diseases and raising quality of human life. One of the infectious agents, measles virus, has been practically eliminated through vaccine programs in developed countries, but globally the virus still remains a threat to children in less… more
Abstract:DESCRIPTION (provided by applicant): In modern day medicine, cellular therapies, regenerative medicine and tissue engineering all involve technologies for harvesting, expanding, modifying and re-implanting live viable cells and tissues. Processes for preparing the therapeutic products that… more
Abstract:DESCRIPTION (provided by applicant): Autologous regenerative medicine tissue therapy costs are very high because when individual tissues are manufactured all the costs fall on a single patient. Allogeneic tissues are cheaper because large tissue batches can be made and the costs are shared by many… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is a feasibility assessment of the ocular delivery of a synthetic peptide, ACT1, for the treatment of Age-Related Macular Degeneration (AMD). AMD is a retinal disease in patients who progressively lose their central vision through… more
Abstract:DESCRIPTION (provided by applicant): According to the World Health Organization, at least 171 million people worldwide are living with diabetes and this figure is likely to more than double by the year 2030. Because of its chronic nature, the severity of its complications and the means required to… more
Abstract:We propose to develop and implement a full-field, non-contacting deformation and strain measurement system capable of operating at frequencies above 1 MHz with unprecedented accuracy. The system will incorporate two ultra-high speed cameras in order to obtain three-dimensional shape and deformation… more
Abstract:ABSTRACT: Kigre proposes to develop and integrate unique radiation hardened, athermal, 1.5um laser gain materials and pumping architectures into high performance optical laser amplifier devices for SATCOM applications. The approach employs long life radiation tolerant pump diodes configured for… more
Abstract:This project targets improved efficiency and lower cost of proton exchange membrane fuel cells through the development of improved water vapor management. Fuel cells are highly efficient, non-polluting source of energy that can significantly decrease the US dependence on foreign oil while reducing… more
Abstract:There is a Global Safeguards need for tamper-indicating coatings of varying complexity for use in the verification and authentication of nuclear security documents, materials, and equipment. Current commercial coatings for seals used in this type of application lack the sophistication necessary for… more
Abstract:This Small Business Innovation Research Phase I project will determine the technical feasibility and the commercial value proposition of a high temperature fiber optic laser coatings for photonic crystal (PC) fiber lasers and large mode area (LMA) double-clad laser. Fiber lasers hold great potential… more
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