Abstract:DESCRIPTION (provided by applicant): The long term goal is the development of better, longer hypothermic storage conditions for liver transplants than currently possible in clinical practice using novel insect antifreeze proteins. Hypothermic injury result
s in vascular dysfunction during liver… more
Abstract:DESCRIPTION (provided by applicant): More than 43,000 Americans die each year from liver disease, making it the 10th leading disease- related cause of death in the US. Cirrhosis with irreversible injury and scarring of the liver, is the most prevalent caus
e of liver failure and is attributable to… more
Abstract:DESCRIPTION (provided by applicant): Compared to current practice with whole-body-gradient coils, an advanced head gradient coil promises over twice the gradient strength (for higher resolution) and at least three times higher slew rates (for faster imagi
ng sequences), with an order of magnitude… more
Abstract:Mobile Ad Hoc Networks (MANETs) are expected to play a vital role in the network-centric warfare paradigm. Among the many technical challenges that must be solved before MANETs can fulfill their envisioned role is the issue of network management. Policy-based network management is an effective… more
Abstract:DESCRIPTION (provided by applicant): As recently as 2005-2006, a massive chikungunya (CHIK) outbreak occurred in the French Island of R union, infecting 35% of its 785,000 inhabitants and killing 237. Additionally, this disease is currently endemic in Indi
a, in which 1.4 to 6.5 million cases are… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop the production and application of low dielectric fibers for use in high frequency circuit board applications. As the frequency of digital communications approaches the frequency at which microwave ovens work, the… more
Abstract:The objective of this proposal is to demonstrate the feasibility of a direct laser diode array side pumped large mode area high power eye-safer fiber laser. Traditional laser diode end pumped single mode fiber laser designs are limited in terms laser power pumping and extraction. Double clad large… more
Abstract:The concept of decontaminating bilge water by a novel regenerative filtration technology incorporating easy cleaning by Back-Flush and combined with in-line inertial separation device was proposed for Phase I. A scaled down lab testing apparatus for demonstrating the feasibility of this concept was… more
Abstract:Nitek Inc. proposes to develop deep ultraviolet light emitting diodes having high quantum efficiency, long device lifetime, and large emission area to make usable for force protection objectives of bio-agent threat detection and maneuver sustainment objectives of potable water. The advancements in… more
Abstract:This Small Business Innovation Research project is to develop a novel semiconductor growth technique resulting in low dislocation density AlInGaN material that can be used to advance the current state of III-Nitride semiconductor device performance. The growth technique termed Metalorganic Hydride… more
Abstract:This SBIR Phase I research program will develop high power, large area, deep ultraviolet LEDs based on a novel vertically conducting geometry that is arbitrarily scalable. AlInGaN based deep ultraviolet LEDs have recently been developed and commercialized. The performance of these UV LEDs has… more
Abstract:The objective of this proposal is to develop enabling technology for the production of bulk scintillating nanocomposites that have gamma radiation detection properties of single crystal NaI but with the manufacturability of plastic scintillators. These performance criteria may be met by developing… more
Abstract:This Small Business Innovation Research Phase I project will develop a new discovery by Tetramer which indicates that the addition of a very small amount of nanotubes to poleable polymers can provide an 6X increase to the piezoelectric performance of the composite. This effect, called… more
Abstract:This Small Business Innovation Research Phase II project aims to develop a new gas separation polymer membrane technology created in Phase I to significantly improve the ability to separate carbon dioxide from methane. Successful utilization of this new technology to separation of these… more
Abstract:DESCRIPTION (provided by applicant): BTG1 is a transcription regulatory protein that interacts with different transcription factors and nuclear receptors. BTG1 acts as a tumor suppressor and as a mediator of myogenic and erythroid differentiation. BTG1 tra
nscription is positively regulated by… more
Abstract:DESCRIPTION (provided by applicant): This project is aimed at developing a new class of drugs, which act by inhibiting pathogenic activities of senescent cells. Cell senescence occurring as a result of aging or cellular damage, is associated with upregulat
ion and secretion of proteins implicated in… more
Abstract:The proposal calls for development of novel type of RF switches for JTRS using patented III-Nitride insulated gate heterostructure field-effect transistors (MOSHFETs). III-Nitride MOSHFETs are excellent candidates for high-power RF stages of JTRS. They possess the highest power densities, highest… more
Abstract:Two complementary approaches to develop next generation of large area, high-efficiency and high-power deep ultraviolet light emitting diodes (DUV LED) are being proposed. Firstly, due to the lack of adequate quality native substrates, DUV LEDs are made from heteroepitaxial AlGaN films grown on… more
Abstract:DESCRIPTION (provided by applicant): This proposal seeks to develop, test, gain regulatory approval and distribute for continuing evaluation, a lightweight, broadly useful children's wheelchair that is suited particularly for high-tone children. The chair
is comprised of a synthetic resin-based,… more
Abstract:This Small Business Innovation Research Phase I project is to develop methods of sorting metallic and semiconducting single-walled carbon nanotubes (SWNT) in an economically scalable manner and use them to form thin films. The goal of this proposal is to demonstrate the technological and commercial… more
Abstract:This Small Business Innovation Research Phase I project will prove out the concept that appropriately doped single crystals of lanthanide oxides (i.e. Yb:Sc2O3) can be grown via a commercially viable hydrothermal process. These crystals will enable the development of new high powered diode pumped… more
Abstract:DESCRIPTION (provided by applicant): The ability of islet transplantation to reproducibly reverse diabetes for extended periods has been demonstrated in recent clinical studies. However the need for 2-3 donor organs per transplant means that less than 1% o
f the insulin-dependent diabetes (IDDM)… more
Abstract:DESCRIPTION (provided by applicant): Transplantation of islets of Langerhans for the clinical treatment of Type I diabetes has had a resurgence of interest due to results obtained using the Edmonton protocol . However, at this time, procurement of donor p
ancreases for islet isolation and… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to develop a series of ultra-high-performance, double-tuned, cryogenic, cost-effective, MRI rf coil platforms, especially for improved MR spectroscopy (MRS) in pre-clinical studies in small
animals at high-fields. Substantial gains… more
Abstract:DESCRIPTION (provided by applicant): Available methods for molecular structure determination, based primarily on x-ray crystallography and Nuclear Magnetic Resonance (NMR) solution methods, have had limited success on the insoluble proteins that are critic
al to bio- logical function. Various recent… more
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