Abstract:DESCRIPTION (provided by applicant): Molecular interactions form the foundation of biology and chemistry. They are central to life itself and determine catalytic activity, cellular function, and therapeutic efficacy. The vast majority of diagnostic procedures depend on some type of specific… more
Abstract:This Small Business Innovation Research (SBIR) Phase I Project seeks to solve the problems of limited voltage, energy density, and lifetime in Electric Double Layer Capacitors (EDLCs). These issues have largely lead to the failure of EDLCs to become a significant part of the energy storage landscape… more
Abstract:DESCRIPTION (provided by applicant): Expressing bacterial bioluminescence in human cell lines: Engineering autobioluminescent reporter cells to screen for endocrine disruptor chemicals Project Summary This Small Business Innovation Research Phase I projectproposes to engineer an autobioluminescent… more
Abstract:Microfabricated chemical and biological sensors serve as an interface between biologic and electronic systems. Previously, through TATRC-funded research grants (W81XWH-05-2-0064, W81XWH-10-1-0358), we have investigated the behavior and detection of propofol using electrochemical (EC) methods. Using… more
Abstract:Diabetes is an epidemic disease in the United States and worldwide. Diabetes care accounts for 10% of all U.S. healthcare costs, most of which is consumed in the care of complications from diabetes, but also includes lost economic productivity from illness, disability and blindness. Despite the high… more
Abstract:Rotavirus is the most common cause of debilitating diarrhea, dehydration and death in infants and young children around the globe. Currently approved live oral vaccines (Rotarix® and RotaTeq®) are only -50% or less effective in children from developing countries. This reduced efficacy is due to… more
Abstract:The market for natural colorants is growing. Trends in food, cosmetics, and textiles show consumers are concerned over the use of synthetic, petroleum-derived dyes and seek a more environmentally friendly option. However, manufacturers cannot compromise on quality, stability, or functionality of… more
Abstract:Constitutively activated forms of ALK caused by genetic aberrations have been shown to cause an expanding variety of human cancers. The FDA recently approved the Pfizer drug Xalkori (crizotinib) to treat patients with non-small cell lung cancers (NSCLC) that express ALK. Numerous other… more
Abstract:Lung cancer is the main cause of cancer mortality worldwide with 80% non-small cell lung cancer (NSCLC) in type and mainly driven by three mutually exclusive oncogenes, EGFR, KRAS and ALK (collectively between 30-60% of all NSCLC cases). Oncogenic driverssuch as ROS1 and RET fusions and DEPDC1… more
Abstract:Utilizing directed energy weapons effectively in an offensive situation or determining the level of protection needed for defense requires the ability to select the proper DEW source characteristics and method of delivery based on the target, any shielding and the desired effect. This is an… more
Abstract:Accurate Automation Corporation proposes an innovative application of virtualization tools to complex information systems, especially the Joint Multi-mission Protection System (JUMPS). The program includes three parts. 1. A plan will be developed and implemented to facilitate the operation and to… more
Abstract:Accurate Automation Corporation proposes to develop a system for a self-contained missile launchable RF Generator based on a frozen wave transmission line technique. The RF transmission line will be charged through an optically activated switch fabricated from silicon carbide. A high energy pulsed… more
Abstract:Aging and obsolescence issues have recently led to problems with the rod control systems of existing pressurized water reactors. These issues, along with plans for plant life extension, have prompted the industry to actively seek viable options to monitor the health of these systems in order to… more
Abstract:Current designs of Light Water Reactors (LWR) are equipped with control and shutdown rods that are inserted and withdrawn from the reactor core for reactivity control. In particular, the Control Element Drive Mechanism (CEDM) system is widely used for regulating plant power levels and core power… more
Abstract:Small modular reactors (SMRs) are at the forefront of the nuclear industrys options for deployment of new reactors to meet the growing electricity needs of the world. However, the designs of SMR plants are not yet far along enough to know the type and number of instruments that will be included in… more
Abstract:Cryogenic fluid handling applications require a reliable actuation technology that can handle very low temperatures. A novel EM hammer drive technology is proposed for use in cryo-propellant fuel storage and regulation valves/devices. In addition to high force, the new drive technology offers… more
Abstract:With tissue engineering science offering promising biomedical interventions for previously untreatable injuries or diseases, many researchers are investigating the use of nanofiber-based medical vehicles for regenerative medicine. The challenge is to produce such vehicles outside of a small-scale… more
Abstract:The overall objective of the Phase II effort is to enhance the capability of the UCDS process to simulate and predict the characteristics of combustion instability in propulsion devices, specifically focusing on the propulsion devices used in missile defense applications. GTL shall apply proven… more
Abstract:The UCDS process is the result of 50 years of research into combustion instability by the worlds leading scientists and engineers. The breakthroughs that created UCDS have provided a solid analytical foundation upon which tools can be developed and applied. One of these is the UCDS nonlinear tool,… more
Abstract:The Advanced FlywheelTM (AF) technology utilizes an innovative configuration in conjunction with modern materials to deliver a flywheel energy storage system with an energy density in excess of 500 W-hr/kg and over 420 W-hr/liter. Using this technology, GTL proposes to develop an FOB scale (150 KWh)… more
Abstract:In the Phase II effort, GTL will build upon the foundation provided by the Phase I effort to develop a family of SMFB products that can be used by thermoplastic matrix composite (TPMC) developers and manufacturers to efficiently and affordably fuse TPMC components together. The effort will seek to… more
Abstract:DESCRIPTION (provided by applicant): Deep brain stimulation has risen as a neurosurgical procedure of choice for patients with disabling neurological or psychiatric disorders for its abiliy to modulate improvement in the activity of certain circuits. The procedure is currently approved for treatment… more
Abstract:Large area neutron detectors with high efficiency, high resolution, high count-rate capability, and fast timing capabilities are required to meet the specific neutron diffraction and imaging needs of the Spallation Neutron Source (SNS) at the Oak Ridge National Laboratory. Due to the current… more
Abstract:DOE Nuclear Physics low-background rare-particle detection arrays require germanium detectors having the minimum possible background and maximum sensitivity. Larger p-type point-contact germanium detectors having better performance are being experimentally developed through collaboration with DOE… more
Abstract:ABSTRACT: A Novel Superconducting Magnetic Energy Storage (SMES) system is proposed. The Tai-Yang Research Company (TYRC) of Tallahassee, FL in collaboration with the Center for Advanced Power Systems (CAPS) also of Tallahassee, FL proposes in Phase 1 to design a prototype SMES system with… more
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