Abstract:Rotavirus is the most common cause of debilitating diarrhea, dehydration and death in infants and young children around the globe. Currently approved live oral vaccines (Rotarix® and RotaTeq®) are only -50% or less effective in children from developing countries. This reduced efficacy is due to… more
Abstract:The market for natural colorants is growing. Trends in food, cosmetics, and textiles show consumers are concerned over the use of synthetic, petroleum-derived dyes and seek a more environmentally friendly option. However, manufacturers cannot compromise on quality, stability, or functionality of… more
Abstract:Constitutively activated forms of ALK caused by genetic aberrations have been shown to cause an expanding variety of human cancers. The FDA recently approved the Pfizer drug Xalkori (crizotinib) to treat patients with non-small cell lung cancers (NSCLC) that express ALK. Numerous other… more
Abstract:Lung cancer is the main cause of cancer mortality worldwide with 80% non-small cell lung cancer (NSCLC) in type and mainly driven by three mutually exclusive oncogenes, EGFR, KRAS and ALK (collectively between 30-60% of all NSCLC cases). Oncogenic driverssuch as ROS1 and RET fusions and DEPDC1… more
Abstract:Utilizing directed energy weapons effectively in an offensive situation or determining the level of protection needed for defense requires the ability to select the proper DEW source characteristics and method of delivery based on the target, any shielding and the desired effect. This is an… more
Abstract:Accurate Automation Corporation proposes an innovative application of virtualization tools to complex information systems, especially the Joint Multi-mission Protection System (JUMPS). The program includes three parts. 1. A plan will be developed and implemented to facilitate the operation and to… more
Abstract:Accurate Automation Corporation proposes to develop a system for a self-contained missile launchable RF Generator based on a frozen wave transmission line technique. The RF transmission line will be charged through an optically activated switch fabricated from silicon carbide. A high energy pulsed… more
Abstract:Aging and obsolescence issues have recently led to problems with the rod control systems of existing pressurized water reactors. These issues, along with plans for plant life extension, have prompted the industry to actively seek viable options to monitor the health of these systems in order to… more
Abstract:Current designs of Light Water Reactors (LWR) are equipped with control and shutdown rods that are inserted and withdrawn from the reactor core for reactivity control. In particular, the Control Element Drive Mechanism (CEDM) system is widely used for regulating plant power levels and core power… more
Abstract:Small modular reactors (SMRs) are at the forefront of the nuclear industrys options for deployment of new reactors to meet the growing electricity needs of the world. However, the designs of SMR plants are not yet far along enough to know the type and number of instruments that will be included in… more
Abstract:Cryogenic fluid handling applications require a reliable actuation technology that can handle very low temperatures. A novel EM hammer drive technology is proposed for use in cryo-propellant fuel storage and regulation valves/devices. In addition to high force, the new drive technology offers… more
Abstract:With tissue engineering science offering promising biomedical interventions for previously untreatable injuries or diseases, many researchers are investigating the use of nanofiber-based medical vehicles for regenerative medicine. The challenge is to produce such vehicles outside of a small-scale… more
Abstract:The overall objective of the Phase II effort is to enhance the capability of the UCDS process to simulate and predict the characteristics of combustion instability in propulsion devices, specifically focusing on the propulsion devices used in missile defense applications. GTL shall apply proven… more
Abstract:The UCDS process is the result of 50 years of research into combustion instability by the worlds leading scientists and engineers. The breakthroughs that created UCDS have provided a solid analytical foundation upon which tools can be developed and applied. One of these is the UCDS nonlinear tool,… more
Abstract:The Advanced FlywheelTM (AF) technology utilizes an innovative configuration in conjunction with modern materials to deliver a flywheel energy storage system with an energy density in excess of 500 W-hr/kg and over 420 W-hr/liter. Using this technology, GTL proposes to develop an FOB scale (150 KWh)… more
Abstract:In the Phase II effort, GTL will build upon the foundation provided by the Phase I effort to develop a family of SMFB products that can be used by thermoplastic matrix composite (TPMC) developers and manufacturers to efficiently and affordably fuse TPMC components together. The effort will seek to… more
Abstract:DESCRIPTION (provided by applicant): Deep brain stimulation has risen as a neurosurgical procedure of choice for patients with disabling neurological or psychiatric disorders for its abiliy to modulate improvement in the activity of certain circuits. The procedure is currently approved for treatment… more
Abstract:Large area neutron detectors with high efficiency, high resolution, high count-rate capability, and fast timing capabilities are required to meet the specific neutron diffraction and imaging needs of the Spallation Neutron Source (SNS) at the Oak Ridge National Laboratory. Due to the current… more
Abstract:DOE Nuclear Physics low-background rare-particle detection arrays require germanium detectors having the minimum possible background and maximum sensitivity. Larger p-type point-contact germanium detectors having better performance are being experimentally developed through collaboration with DOE… more
Abstract:The Navy incurred approximately $3 billion in aircraft corrosion maintenance costs. Design analysis tools are largely empirical and are derived from physical testing of the basic material specimens, which do not have the capability to account for degradation of these properties due to operational… more
Abstract:DESCRIPTION (provided by applicant): This SBIR Phase I project will design, build, and test the Atmospheric Plasma Produce Disinfection System (APPDS), an in-line processing unit that will operate continuously to treat fresh produce. The APPDS will reducethe risk of foodborne infections by… more
Abstract:DESCRIPTION (provided by applicant): Germanium gamma-ray imaging detectors will improve the quality of in-vivo molecular-imaging applications. The objective of this program is the development of the Germanium Gamma Cameras (GGCs) as modular component detector heads suitable for convenient… more
Abstract:DESCRIPTION (provided by applicant): Stroke is the 3rd leading cause of death and the primary cause of severe, long term disability. Each year 795,000 Americans have a stroke and the annual costs to the economy are 57.9 billion. The vast majority of acute ischemic strokes are caused by a thrombus… more
Abstract:DESCRIPTION (provided by applicant): Each year, as many as 2 million Americans develop venous thromboembolism (VTE). VTEs are blood clots in the legs (venous thrombosis) that may travel to the lungs (pulmonary embolism). It is estimated that 10-20% of VTEpatients die, and the annual direct costs are… more
Abstract:The variation between peak and off-peak electricity demand fluctuates up to 70 percent over the course of a 24 hour cycle. This degree of variability is a driver for costly inefficiencies within the power gridto prevent blackouts and meet customer demandas well as power sell offs to consume excess… more
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