Abstract:DESCRIPTION (provided by applicant): Autoimmune diseases are thought to arise from abnormalities in innate or adaptive immune responses and most likely have both genetic and environmental components. Diagnosis of autoimmune disease is often difficult, as t
he symptoms can be relatively nonspecific.… more
Abstract:DESCRIPTION (provided by applicant): The aim of the proposed research is to develop an enabling technology that will allow development of a molecular diagnostic for identification and discrimination among closely related bacterial species that cause signif
icant disease at low microorganism numbers.… more
Abstract:Phase II will evaluate the four most promising training interventions determined from Phase I and their impact on the HF skill deficiencies of Channelized Attention, Task Misprioritization, Selected the Wrong Course of Action, and Crew Coordination. The training interventions that will be… more
Abstract:Existing and planned neutron facilities, such as the Spallation Neutron Source, generate bursts of cold neutrons for materials research. The efficiency of the beam line components, which convert the fast neutrons to a cold neutron beam, determines the usefulness of the facility. Existing solid… more
Abstract:This Phase II proposal applies the optimization strategy researched and developed from Phase I. The research conducted in Phase I defined optimization strategies for use within logistical planning models that focused on resource usage against resource availability within a dynamic environment where… more
Abstract:Space Mechanism testing often requires precision motion control in a cryogenic and high vacuum environment. Precision position devices that can provide motion over large distances and with relatively high forces are required. DSM proposes a revolutionary piezoelectric motorized stage that is… more
Abstract:Piezoelectric motors operate on the principal of high frequency oscillation of high force precision ceramic elements. The high power oscillations are converted to rotary motion through a novel conversion mechanism to produce high torque precision motion when compared with traditional… more
Abstract:Military personnel are often subjected to significant vertical acceleration while carrying out their duties. Such acceleration can interfere with the individual's ability to view platform-fixed displays by inducing spatial disorientation and/or motion sickness. The resulting decrease in personnel… more
Abstract:Dynamic Structures and Materials, LLC (DSM) proposes the development of a compact, proportional piezoelectric motor actuation technology with miniature electronics, optimized actuator hardware and integrated position feedback capability. The new actuation system will be optimized and characterized… more
Abstract:Military personnel on the Expeditionary Fighting Vehicle (EFV) may be subjected to significant levels of shock and vibration loading in the course of a military maneuver. The shock and vibration loading can interfere with crew duties and cause fatigue and distraction. Dynamic Structures and… more
Abstract:This Small Business Innovation Research Phase I research project will develop a low cost plasma treatment methodology capable of increasing adhesive strength between electrospun nanofibers and substrates, as well as change the functionality of nanofibers to develop functional textile material for… more
Abstract:Characterizing turbine engine rotor vibratory characteristics is becoming increasingly complex with the introduction of advance technologies, such as integrally bladed rotors (IBR), low aspect ratio airfoils, 3-D aerodynamic computational fluid dynamics (CFD) design blades, and advance materials. … more
Abstract:Manufacturing processes are typically delayed from several minutes to several hours while coatings, sealants, and adhesives sufficiently cure to allow subsequent operations. Local environmental conditions can accelerate or decelerate cure depending on the chemistry of the materials, which makes… more
Abstract:DESCRIPTION (provided by applicant): Much efforts in gene expression analysis in the past have been focused mainly on the messenger RNAs (mRNAs), thanks to the availability of Differential Display (DD), SAGE and DNA microarray technologies, which all targ
et the poly(A) tails present in most… more
Abstract:Gloyer-Taylor Laboratories has identified a suite of technologies that can provide a tactical missile with a high degree of energy management capability and proposes to demonstrate these technologies by developing the AVATAR (Adaptive VAriable Trajectory Attack and Reconnaissance) Multi-role… more
Abstract:The seats used to carry troops in large Special Operation or Search & Rescue helicopters only provide limited protection in the event of a crash. These troop seats do not adequately attenuate the energy during a crash pulse or restrain the crewmember during impact and roll-over events. The… more
Abstract:Government digital libraries have a unique opportunity to facilitate communication between scientific communities of common interest. These libraries can add functionality to their electronic dissemination products, providing a catalyst for communication and collaboration among users. However, to… more
Abstract:Users of federated search systems need to have direct access to the publisher's copy of the electronic full text or, at a minimum, a direct link to the publisher's website. In many cases, there exists a disparity between the data collections of the underlying databases, or collection nodes, which… more
Abstract:This SBIR Phase II, Requirements-Based Cost Models, will develop software to enable cost managers to extrapolate costs of complex systems with higher fidelity than current approaches. Identifying the true costs of transitioning technologies from concept to production is complicated by many factors… more
Abstract:DESCRIPTION (provided by applicant): MDI 301 is a synthetic retinoid that is similar to all-trans retinoic acid (RA) in its ability to stimulate collagen synthesis and inhibit the major collagen-degrading enzymes in skin. A feature that distinguishes MDI
301 from RA is its lack of irritation when… more
Abstract:DESCRIPTION (provided by applicant): MDI-301 is a synthetic retinoid. MDI-301, like RA, induces collagen synthesis and reduces expression of collagen-degrading matrix metalloproteinases in the skin. This agent also induces epidermal thickening. However, un
like RA, MDI-301 is non-irritating when… more
Abstract:A 2nd harmonic compact low voltage gyrotron operating in the TE021 mode at 94 or 95 GHz on the second cyclotron harmonic produced by a compact normal magnet will produce 100kWCW or more at high efficiency (35% or better before collector energy recovery) using a 50 kV magnetron injection gun (MIG)… more
Abstract:Electronic waste (e-waste) is one of the most rapidly growing waste problems worldwide. Improper handling of e-waste results in vast amounts of toxic waste being sent to landfills and leaching into the water supply. Because of these concerns, e-waste recycling is a rapidly growing industry.… more
Abstract:DESCRIPTION (provided by applicant): Our long-term research goal is to develop an ophthalmic, nanofiber-based, biodegradable device that will provide extended release of therapeutic agents to the posterior segment of the eye via transscleral and intravitr
eal approaches. This platform device will… more
Abstract:Currently available neutron detectors are limited in their ability to be used with the intense neutron beams used for the advanced study of materials at large-scale national facilities. A large number of neutron-scattering experiments require beam monitors to operate in an intense neutron beam flux… more
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