Abstract:Bumper systems having lower cost and high performance are the goal of this research effort. To achieve this goal the use of recycled materials and advanced processing techniques will be investigated. These bumper systems will serve to protect the structural integrity of ships, piers, and offshore… more
Abstract:Elastomeric O-rings provide a critical sealing funcion in a myriad of devices of military and commerical interest. A critical problem with currently available O-rings occurs when the O-ring material stiffens at low temperatures, causing a failure in sealing. Previous work by the Army has indicated… more
Abstract:Phased array designs for microwave and communication applications incorporate large numbers of transmit/receive (T/R) modules. High part counts lead to concern about T/R module reliability and improvements in semiconductor device manufacturing techniques and materials technology make lifetime… more
Abstract:The use of lead projectile cores in current U.S. Army small caliber ammunition has caused increasing concern over the environmental contamination of military firing ranges and surrounding areas. A number of military firing ranges are in danger of being closed due to high levels of lead… more
Abstract:Sudden, catastrophic fatigue failures in 40 to 50 year old Navy cranes pose a significant danger to personnel and facilities. These aging cranes are currently used to lift nuclear materials and other sensitive payloads. Nondestructive Evaluation (NDE) methods of fatigue crack analysis are… more
Abstract:AIDS is a fatal disorder of the immune system caused by the HIV and is a widespread epidemic. The lobjective of this work is to treat human AIDS patients with a novel oligonucleotide (T30177) that haanti-HIV activity. We will perform preclinical animal pharmacology studies, including… more
Abstract:Cytomegalovirus (CMV) causes severe infections in infants, organ transplant recipients and AIDS patlong term objective of this work is to treat humans who have cytomegalovirus infections with a novelspecific aims of this grant are to perform animal pharmacology studies, including efficacy,… more
Abstract:We will develop a new class of oligonucleotides, which fold themselves into ordered structures andmainly of deoxyguanosine and deoxythymidine (GTOs), as therapeutic antiviral agents active against HGTOs as antiviral agents represents the results of a productive investigation into the mechanism… more
Abstract:We will develop certain structure activity relationships with respect to a novel class of antiviralconduct preliminary experiments designed to define the mechanism of action for these drugs. Preliminestablished that certain alkenes, when attached to a guanine congener, provide potential antiviral… more
Abstract:Antisense and triple helix-forming oligonucleotides (TFOs) have great potential as therapeutic agenspecifically block the expression of deleterious genes. We will develop novel delivery vehicles, tointernalization and membrane permeability of oligonucleotides. These compounds are polyaminolipids… more
Abstract:This project will produce a single CD-ROM containing all of the March Current Population Survey data from 1964Â¿1993. The project will be combined with software that will permit easy access to the coding, universe information, and questionnaire context of all variables. The foundations for this… more
Abstract:The purpose is to make available to the scientific community recent statistical and econometric techniques for the modeling of demographic behavior. The software developed as part of the project will allow demographers, sociologist, economists, epidemiologist, and researchers in other fields to… more
Abstract:It is the purpose of this proposal to develop the key technologies required to construct a man-portable advanced multimedia imaging helmet system. We will develop and demonstrate three helmet designs including a monocle headset, a goggle headset, and a face plate. These three helmet platforms will… more
Abstract:This research will develop an effective topical medication for the treatment of genital herpes lesitetracaine as the active. ViroTex has found clinically that a topical cream containing 2% tetracainesulfate (the OTC product Viractin/Â¿) reduces the time to healing of herpes labialis lesions by 30%… more
Abstract:ZC&H Dynamic Systems proposes the design, prototype and test of an instantaneous RAIM algorithm based on nonlinear regression that will exploit both pseudorange-based position-bias information and delata- pseudorange-based velocity-frequency offset information. This is in contrast to the RTCA's… more
Abstract:We will develop porous silicon based detector chips for the identification of biomoleculefragments. Patches of porous silicon on a silicon wafer act as active sieves, loaded with taggingmolecules, where during passage through it biomolecule fragments are identified by their response afterattachment… more
Abstract:Nucleic acid hybridization reactions are at the heart of a number of powerful assays used in molecular biology research and increasingly in diagnostic applications. Hybridization reactions typically require long incubation times, i. e. overnight. Recent work has demonstrated that a ribonucleoprotein… more
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