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Displaying 5076 – 5100 of 5805 Awards
Company: Triplex Pharmaceutical Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: TRIPLE HELIX FORMING OLIGONUCLEOTIDES (TFOS) OFFER THE POTENTIAL TO SPECIFICALLY MODULATE EXPRESSION OF ANY GENE IN A SEQUENCE DEPENDENT MANNER. AT PRESENT, TFOS CAN BE DESIGNED TO BIND TO CERTAIN TARGETS IN DUPLEX DNA, FORMING A LOCALIZED THREE-STRANDED STRUCTURE. SUCH STRUCTURES CAN BLOCK ACTION… more
Company: Triplex Pharmaceutical Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: THE PRIMARY GOAL OF THIS STUDY IS TO CHEMICALLY REFINE A CLASS OF SEQUENCE-SPECIFIC, DNA BINDING, TRIPLE HELIX-FORMING OLIGONUCLEOTIDES (TFOS). THE UNIQUE FEATURE OF THESE TFOS IS THAT BINDING OF THE THIRD STRAND TO ITS DUPLEX DNA TARGET IS PH INDEPENDENT AND IS STABILIZED BY GGC AND TAT TRIPLETS… more
Company: Vestec Corpon Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: THE OVERALL GOAL OF THIS PROJECT IS TO DEVELOP A NEW LASER DESORPTION TIME-OF-FLIGHT (LD/TOF) MASS SPECTROMETRIC TECHNIQUE FOR THE DETERMINATION OF METAL ISOTOPE RATIOS THAT CAN BE READILY APPLIED TO STUDIES OF THE METABOLISM OF BIOLOGICALLY SIGNIFICANT BULK AND TRACE ELEMENTS. THE PHASE I GOALS OF… more
Company: Viscoustech Inc Agency/Program/Year/Phase: DOE / SBIR / 1992 / 1
Abstract: N/A
Company: Lynntech, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 2
Abstract: WATER FOR PHARMACEUTICAL PREPARATION AND PARENTERAL THERAPY MUST BE OF HIGH CHEMICAL PURITY, STERILE, AND FREE FROM FEVER-PRODUCING BACTERIAL ENDOTOXINS. THE REMOVAL OF PYROGENS FROM WATER BY DISTILLATION IS EXPENSIVE. ACCEPTABLE ALTERNATIVES TO DISTILLATION REQUIRE METICULOUS MAINTENANCE, EXTENSIVE… more
Company: Lynntech, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1992 / 2
Abstract: "ADVANCED OZONATION PROCESSES" (I.E., THE COMBINATION OF OZONE WITH HYDROGEN PEROXIDE OR UV LIGHT), HAVE APPLICATIONS TO THE REMOVAL OF ORGANIC POLLUTANTS FROM WATER. ONE OF THE MAIN BARRIERS TO IMPLEMENTING AOPS HAS BEEN THE HIGH CAPITAL AND OPERATING COSTS FOR OZONE GENERATION. LYNNTECH, INC., HAS… more
Company: Lynntech, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1992 / 1
Abstract: FUEL CELLS OPERATING IN AQUEOUS ELETROLYTES (BELOW 200¿C, DEPENDING ON THE CHOSEN ELECTROLYTE TECHNOLOGY) NORMALLY OPERATE ON HYDROGEN FUEL AND OXYGEN (OR AIR) AS THE OXIDANT. HIGH-PERFORMANCE FUEL CELL ELECTRODES REQUIRE HIGH CATALYST SURFACE AREAS, GOOD ELECTRONIC CONDUCTIVITIES AND BROAD… more
Company: Lynntech, Inc. Agency/Program/Year/Phase: NSF / SBIR / 1992 / 1
Abstract: AT PRESENT GLUCOSE IS COMMERCIALLY REDUCED TO SORBITOL BUT THE OPERATING CONDITIONS USED (HIGH TEMPERATURE AND HIGH HYDROGEN GAS PRESSURE) ARE UNDESIRABLE AND DANGEROUS. AN ALTERNATIVE APPROACH IS THE PAIRED ELECTROCHEMICAL SYNTHESISOF SORBITOL AND GLUCONIC ACID IN AQUEOUS SOLUTIONS AT AMBIENT… more
Company: Lynntech, Inc. Agency/Program/Year/Phase: USDA / SBIR / 1992 / 1
Abstract: SORBITOL, GLUCONIC ACID AND METAL GLUCONATES ARE USED IN MANY DIVERSE FIELDS, INCLUDING FOODS, PHARMACEUTICALS, COSMETICS, TEXTILES, AND POLYMERS. AT PRESENT, GLUCOSE IS COMMERCIALLY REDUCED TO SORBITOL BUT THE OPERATING CONDITIONS USED (HIGH TEMPERATURE AND HIGH HYDROGEN GAS PRESSURE) ARE… more
Company: Lynntech, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1992 / 1
Abstract: N/A
Company: Lynntech, Inc. Agency/Program/Year/Phase: USDA / SBIR / 1992 / 1
Abstract: N/A
Company: Lynntech, Inc. Agency/Program/Year/Phase: NASA / SBIR / 1992 / 1
Abstract: N/A
Company: Annapolis Research & Dev Agency/Program/Year/Phase: DOD / SBIR / 1991 / 2
Abstract: THIS PROPOSAL WILL DEMONSTRATE (IN 2" TO 4" SIZE), A NOISE REDUCING TRIM THAT CAN BE UTOLIZED IN ROTARY CONTROL/ON-OFF BALL VALVES. THIS VALVE TRIM ADDRESSES NOISE AT THE SOURCE. THE BASIC DESIGN HAS A VARIABLE IMPEDENCE TRIM TO CAUSE A HIGH IMPEDENCE AT LOW ANGLES OF OPENING AND LOW IMPEDENCE (VERY… more
Company: Antropix Corpon Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: WE WILL DEVELOP A LASER SYSTEM THAT IS SUITABLE FOR PERFORMING PHOTOTHERMAL INTRASTROMAL KERATOPLASTY TO CORRECT OCULAR REFRACTIVE ERRORS. LASER PARAMETERS (WAVELENGTH, IRRADIANCE, AND IRRADIATION TIME) AND DELIVERY/GEOMETRY PARAMETERS (BEAM PROFILE, SPOT SIZE, PATTERN, AND SLEW RATE) SHALL BE… more
Company: Argus Pharmaceuticals Inc Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: CYTOTOXIC ACTIVATED MACROPHAGES SECRETE SOLUBLE FACTORS THAT HAVE A VARIETY OF EFFECTS ON TUMOR CELLS. INCLUDED IN THE TUMOR CELL RESPONSE ARE THE INHIBITION OF MITOCHONDRIAL RESPIRATION AND INHIBITION OF DNA SYNTHESIS. A MONOKINE CALLED RIF, WHICH WAS FOUND TO REPRODUCE THESE EFFECTS IN VITRO, HAS… more
Company: Aronex Pharmaceuticals, Inc Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: N/A
Company: Artificial Intelligence Resear Agency/Program/Year/Phase: DOD / SBIR / 1991 / 2
Abstract: THE LONG TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP AND IMPLEMENT A GENERAL SELF-EXTENSIBLE KNOWLEDGE BASED REASONING TECHNOLOGY SPECIFICALLY TARGETED FOR USE IN COMPREHENSIVE MANUFACTURING AND MANAGEMENT OPERATIONS SYSTEMS. THIS TECHNOLOGY SHOULD PROVIDE MANUFACTURING AND MANAGEMENT OPERATIONS… more
Company: Atlantia Energy Corp. Agency/Program/Year/Phase: DOE / SBIR / 1991 / 2
Abstract: COMMERCIAL DISCOVERIES OF OIL AND GAS DEPOSITS IN U.S. DOMESTIC WATERS, PRINCIPALLY GULF OF MEXICO, ARE MOVING TO SIGNIFICANTLY DEEPER WATERS (OVER 400 FT.) AS SHALLOW WATER RESERVES ARE BEING DEPLETED. DEEPWATER EXPLORATION IS CURRENTLY UNDERTAKEN PRIMARILY BY MAJOR OIL COMPANIES, DUE TO ITS VERY… more
Company: AVOX SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: THIS PROJECT WILL DEVELOP A SPECTROPHOTOMETRIC INSTRUMENT TO MEASURE THE TOTAL HEMOGLOBIN CONCENTRATION OF WHOLE BLOODAND THE RELATIVE CONCENTRATIONS OF OXY-, DEOXY-, CARBOXY-, MET-, AND SULFHEMOGLOBIN. THE CHIEF STRATEGY IS TO MAKE BEER'S LAW APPLY TO WHOLE BLOOD BY MINIMIZING THE EFFECTS OFLIGHT… more
Company: AVOX SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: N/A
Company: Baker Engineering and Risk Consultants Inc. Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: THE PROPOSED PROJECT INVOLVES A THOROUGH FEASIBILITY STUDY WHICH WILL RELY HEAVILY ON EXISTING TEST DATA, ANALYSES AND COMPUTER CODES ALREADY APPLICABLE TO THE MEASURE OF QUANTITY-DISTANCE RATIO, AND WHICH WILL LEAD DIRECTLY INTO DETAILED DESIGNS FOR FIELD TESTING FOR PHASE II. SPECIFICALLY, A… more
Company: Betac Corp Agency/Program/Year/Phase: NASA / SBIR / 1991 / 1
Abstract: A PROTOTYPE DIGITAL, VIDEO-INTERACTIVE-BASED, INTELLIGENT, COMPUTER-ASSISTED TRAINING SYSTEM (DVI-ICAT) OR MISSION PLANNING SYSTEM WILL BE DEVELOPED. THE SYSTEM WILL SERVE BOTH AS A LAUNCHING POINT FOR FURTHER PHASE II WORK ON THE SYSTEM AND FOR DEMONSTRATING TO NASA/JSC THE CAPABILITIES AND… more
Company: BIODYNAMIC RESEARCH CORP. Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: THE OPPORTUNITY EXISTS TO EXTEND THE CAPABILITIES OF THE USAF ADVANCED DYNAMIC ANTHROPOMORPHIC MANIKIN (ADAM) WHICH HAS BEEN DEVELOPED TO ASSESS THE INFLUENCE OF HUMAN RESPONSES ON EJECTION SEAT PERFORMANCE. THE MORE REALISTIC ARTICULATIONS AND VERTICAL SPINAL RESPONSE OF ADAM CAN BE SUPPLEMENTED… more
Company: Bioindustrial Technologies, In Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: MICROBIOLOGICALLY INFLUENCED CORROSION (MIC) OF MOST INDUSTRIALLY UTILIZED ALLOYS, INCLUDING THOSE USED IN MANY NAVAL APPLICATIONS, IS WELL ESTABLISHED. MIC OF COATED AND CATHODICALLY PROTECTED MATERIALS IS ALSO WELL DOCUMENTED. THE PROPOSED RESEARCH WOULD EXAMINE THE ROLES OF NATURALLY OCCURRING… more
Company: Cadsa Inc. Agency/Program/Year/Phase: USDA / SBIR / 1991 / 1
Abstract: N/A
Displaying 5076 – 5100 of 5805 Awards
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