Abstract:Triple helix formation between duplex DNA and oligonucleotides has been observed for over twenty years for synthetic polymers and more recently for genomic DNA. Triplex formation prevents the association of proteins with DNA including transcription factors and RNA polymerase. Triple helix formation… more
Abstract:The aim is to test the feasibility of using triple helix (triplex)-forming oligonucleotides as antiviral agents against human cytomegalovirus. Oligonucleotides have long been known to be capable of binding to duplex DNA to form triple helix complexes. Advances in triplex technology now allows the… more
Abstract:Speech disorders affect over 22 million Americans. Many of these individuals suffer from physical or mental handicaps which prevent the more common speech substitutes of sign language or conventional text-to- speech devices. The device, which is extremely flexible and economical, can reproduce words… more
Abstract:An important aspect in the design of aircraft structure and aeropropulsion components made of high temperature composite materials is damage tolerance and life prediction. Many components contain joints between co posites and metals. There is a need to develop methods for predicting life of such… more
Abstract:LIGHT SCATTERING (LS) IS ONE OF THE MOST COMMON TECHNIQUES FOR POLYMER CHARACTERIZATION. THE LS INTENSITY AND ITS ANGULAR DISSYMMETRY ARE THE TWO EXPERIMENTAL RESULTS THAT GIVE THE POLYMER MOLECULAR WEIGHT (MW) AND MOLECULAR SIZE (RADIUS-OF-GYRATION RG) INFORMATION RESPECTIVELY. WHEN A MULTI-ANGLE… more
Abstract:THE PROCESSES AND EQUIPMENT FOR HANDLING SOLIDS AND SLURRIES ARE QUITE INEFFICIENT WHEN COMPARED WITH EQUIPMENT THAT HANDLES LIQUIDS AND GASES. THIS IS LARGELY BECAUSE DESIGNERS DO NOT CLEARLY UNDERSTAND THE BEHAVIOR OF GRANULAR SOLIDS AND SLURRIES SUCH AS COAL-WATER SLURRIES. IN PHASE I OF THIS… more
Abstract:The long term objective of this research is to develop high performance instrumentation for multiple channel neuronal waveform acquisition and data analysis. This plan builds on the Multichannel Neuronal Acquisition Processor (MNAP) hardware platform capable of acquiring spike intervals, waveforms… more
Abstract:THERMOPLASTIC ELASTOMER (TPE) BY INJECTION MODLING OFFERS AN ALTERNATE METHOD FOR FORMING CHEMICAL PROTECTIVE GLOVES A SOCMPARED TO THE CONVENTONAL DIP PROCESS USING BUYTL RUBBER SOLUTIONS. THE ADVENT OF VARIOUS TPES WITH OLEFINIC, STYRENIC, URETHANE, ENGINEERING RESINS AND ALLOYS AND BLENDS OFFER… more
Abstract:A VARIETY OF DIFFERENT APPROACHES ARE BEING TAKEN TO INCREASE THE SPED AND DECREASING THE SPEED AND DECREASE THE COST OF DNA SEQUENCING. ONE OF THE MAJOR CURRENT SEQUENCING TECHNOLOGIES IS THE DIDEOXYNUCLEOTIDE CHAIN-TERMINATING APPROACH ORIGINALLY DEVELOPED BY SANGER. WE WILL USE A VARIANT OF THIS… more
Abstract:AN ELECTROMECHANICALLY DRIVEN TOTALLY IMPLANTABLE TOTAL ARTIFICIAL HEART (TAH) WAS DEVELOPED RECENTLY AT BAYLOR COLLEGE OF MEDICINE. THIS EXPERIMENTAL PROTOTYPE WAS PROVED TO BE RELIABLE AND EFFECTIVE, YET SMALL ENOUGH TO IMPLANT INSIDE THE CHEST CAVITY OF AN AVERAGE HUMAN PATIENT. THIS TAH SYSTEM… more
Abstract:THE PROPOSED INNOVATION CONSISTS OF A PROGRAMMING ENVIRONMENT WHERE EXECUTION TAKES PLACE THROUGHOUT A (PERHAPS HETEROGENEOUS) NETWORK OF COMPUTING DEVICES. FROM THE PROGRAMMER'S POINT OF VIEW, THE LANGUAGE APPEARS AS AN ICONIC OBJECT FLOW LANGUAGE (SUCH AS PROGRAPH) WITH A FEW EXTENSIONS FOR… more
Abstract:IN THIS PHASE I EFFORT, WE WILL DEMONSTRATE THE ABILITY TO SCALE UP THE PRODUCTION OF A LEAD LIPOSOMAL FORMULATION CANDIDATE OF ACYLATED, LIPOPHILIC RHUTNF. WE WILL SUBJECT THE BACTERIAL RECOMBINANT PROTEIN TO ACYLATION WITH THE N-HYDROXYSUCCUNIMIDE ESTER OF CAPRYLIC ACID (C3) TO ACHIEVE LIMITED… more
Abstract:MITOCHONDRIAL RESPIRATION INHIBITION IN TUMOR CELLS MAY OCCUR IN TWO MANNERS. ONE MECHANISM INVOLVES THE SYNTHESIS OF NITRIC OXIDE (NO) BY MACROPHAGES OR IFN-GAMMA MEDIATED INDUCTION OF NO SYNTHESIS IN TUMOR CELLS. WE HAVE RECENTLY ESTABLISHED A MURINE MACROPHAGE CELL LINE, EA13.5, THAT RELEASES A… more
Abstract:COMMERCIAL AND GOVERNMENT SPACE TRANSPORTATION SYSTEMS DEPEND ON GROUND SUPPORT FOR NAVIGATION. THE GROUND SOLUTION CAN BE COSTLY AND MAY PROVIDE LESS ACCURACY THAN NEEDED. A GPS-BASED REAL-TIME AUTONOMOUS SPACECRAFT NAVIGATION SYSTEM IS PROPOSED. AN ALGORITHM WILL BE DEVELOPED WHICH COMBINES… more
Abstract:Microbiologically influenced corrosion (MIC) of most industrially utilized alloys, including those used in many Naval installations, is well established. However, the diagnosis of MIC type corrosion is often difficult to make using the techniques commonly employed requiring large amounts of tiem and… more
Abstract:THE PROPOSED PROJECT WILL DETERMINE THE FEASIBILITY OF COMMERCIALIZING RURAL INTEGRATED TECHNOLOGY CENTERS (RITC'S)IN LOCAL COMMUNITIES FOR MODERNIZATION OF SERVICES AND GREATER ACCESS TO EXISTING AND FUTURE PROGRAM AND INFORMATION RESOURCES. RURAL COMMUNITIES FACE CHALLENGES INOBTAINING THE… more
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