Abstract:DESCRIPTION (provided by applicant): The purpose of this Phase II STTR project is to develop a polymeric system for the combination delivery of two antineoplastic agents, gemcitabine and paclitaxel. Based on the successful results of the STTR Phase I award, this Phase II proposal details the… more
Abstract:Analog-to-digital converters (ADCs) are necessary for many applications, including sensors, hardware based radio station, wireless systems, instrumentation, and power. These applications are often used in harsh environments which magnify the difficulty of designing complex ADCs due to the fact that… more
Abstract:Silicon Technologies Inc. (STI) proposes to develop a data conversion architecture using radiation hardened ADC and DAC converter technologies. The circuit topology will be based on a fully differential, redundant SAR ADC which utilizes three high speed comparators to enable single clock conversion… more
Abstract:ABSTRACT: Cache memory is normally built with Static Random-Access Memories (SRAM ) and are necessary for many applications, including sensors, hardware based radio station, wireless systems, instrumentation, video, and power. These applications are often used in harsh environments including the… more
Abstract:ABSTRACT: Non Volatile Memories (NVM) are necessary for many applications, including sensors, hardware based radio station, wireless systems, instrumentation, video, and power. These applications are often used in harsh environments including the medical radiological, nuclear, space, and military… more
Abstract:The Navy and USMC are embarking on an aggressive power and energy program for applications in surface and underwater vehicles as well as expeditionary systems. Limited by either shipboard space and weight or portability, the Navy and USMC require innovative technology solutions to increase… more
Abstract:ABSTRACT: With shrinking facility budgets and increasingly stringent environmental regulations, United States Department of Defense (DoD) weapon system maintenance facilities are faced with the difficult challenge of maintaining regulatory compliance with limited resources. Moreover, the growing… more
Abstract:The development of large-area (m2) photodetectors with time resolutions of picoseconds (10-12 seconds) and submillimeter space resolutions would open new opportunities in collider detectors at the Energy Frontier, kaon and neutrino experiments at the Intensity Frontier, photon detection in… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will prove the feasibility of a low-dose 4D cone beam tomosynthesis reconstruction algorithm for use in medical image-guided interventions. Despite the availability of highly accurate 3D guidance systems, most image-guided interventions… more
Abstract:A chemical threat agent mode of action is often initiated through a selective interaction with a biological molecule or structure. The agent binding mimics normal cellular processes, but then overruns natural control mechanisms leading to toxic and even lethal effects. The binding may be used as a… more
Abstract:Thermal batteries are single discharge reserve batteries that provide very long shelf life, minimal self-discharge, wide storage temperature range, fast activation under sudden power demand, and also wide range of temperature operating conditions. Such unique properties among electrochemical power… more
Abstract:This Small Business Technology Transfer Phase I project will develop a new Present Weather Sensor (PWS). The impact of this project will be felt in the transportation sector where, annually, 1.4 million traffic accidents are caused by weather at an estimated cost to the nation of $42 billion.… more
Abstract:Energy storage devices in many aerospace applications are facing unique challenges. Most of such applications, including remote surveillance, satellites, reusable launch vehicles, etc. depend on high-performance, highly specialized batteries. In Phase I, STI prepared and tested several sulfur-carbon… more
Abstract:The broader impact/commercial potential of this Small Business Innovation Research (SBIR) phase II project is in removing key manufacturing barriers that are currently hindering commercialization of semiconductor nanocrystals in diverse market segments worldwide. The unique size- and shape-related… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will develop a working prototype of a handheld detector for trace explosives that is smaller, more sensitive, and has faster response times than any commercially available portable device today. Under NSF Phase I SBIR funding of this… more
Abstract:DESCRIPTION (provided by applicant): A range of neurological diseases are now being researched or treated using fully implantable electronic systems to either record or modulate brain activity in humans. These implants are currently being protected using polymer coatings that envelop the implant and… more
Abstract:DESCRIPTION (provided by applicant): The goal of the proposed project is to alleviate the enormous public health burden of heart failure. Heart failure leads to significant morbidity and mortality, affects almost five million Americans, and results in morethan 35 billion dollars in annual healthcare… more
Abstract:With no moving parts other than a syringe pump, this tool will allow for the reliable measurement of flow rate as a function of depth within a geothermal wellbore and thus provide for improved reservoir management. By improving wellbore flow measurements, predictions of well performance will… more
Abstract:DESCRIPTION (provided by applicant): Epoch Telemetry System for Long-Term Monitoring of Biopotentials ABSTRACT Epoch is a wireless, multi- channel biopotential recording system designed for small animal translational research models of human disease developed in Phase I and II. Obtaining long- term… more
Abstract:DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) infection is a significant human health issue, accounting for 50% of liver transplants in the US, with approximately 170 million persons infected worldwide. The current standard of care therapy of PEGylated-interferon and ribavirin is… more
Abstract:The Haber-Bosch process is the dominant industrial method for nitrogen fixation in the world, with production exceeding 140MM tons in 2009. This process of converting nitrogen and hydrogen to ammonia is one of the great scientific achievements in the modern world. However, Haber-Bosch process is… more
Abstract:Advances in soft X-ray detector technology have enabled higher count rates while maintaining high spectral resolution. These new superconducting detectors share the common form of a pixilated active area that must be operated in the milli-Kelvin temperature range below the boiling temperature of… more
Abstract:This Small Business Innovation Research (SBIR) phase I project proposes to develop a novel alternative to sutures for the repair of lacerated digital flexor and extensor tendons. Over 70,000 flexor and extensor tendon repair surgeries are performed yearly in the US, often with sub optimal outcomes.… more
Abstract:The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project derives from the fact that modern Real Time Location Service (RTLS) systems offer the potential to improve the efficiency of warehouses, offices, and hospitals, and to increase the safety of… more
Abstract:The proposed research innovation will create a low-cost, intuitive means for people to have multi-fingered interaction with Robonaut 2 and training simulations via tactile shear feedback. This work builds on the PI's prior university research. Tactile shear feedback imparts friction and shear… more
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