Abstract:DESCRIPTION (provided by applicant): This Phase I proposal addresses the significant need for improved treatment options for patients with liver cancer, the fifth highest incidence of cance in the world. Because of the lack of symptoms, hepatocellular carcinoma (HCC) is detected at advanced stages… more
Abstract:ABSTRACT: Select Engineering Services (SES) has developed a composite Instrument Landing System (ILS) tower that improves sustainability (by eliminating costly maintenance) and increases airfield safety through a frangible design. Current ILS towers are made from steel components and require costly… more
Abstract:ABSTRACT: During Phase I, SES modeled the fuel consumption of a baseline shelter and then modeled the interactive effects of using fuel efficient technologies (lighting, climate control, etc.) instead of the baseline technologies. This work demonstrated the feasibility of improving the fuel… more
Abstract:This project team is developing a prototype of a web-based pre-algebra math game for middle school students for use on tablet and personal computer platforms. The game, called Empires, will be story-based, strategic, and will enable peer-to-peer interactions. The games will be integrated within… more
Abstract:ABSTRACT: Over half of spacecraft system anomalies attributed to interactions with the natural space environmentincluding electron upsets, damage to components, power system debilities, and complete satellite failuresare attributed to spacecraft charging. While measurements of electron emission,… more
Abstract:DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is an irreversible neurological disease that progressively causes a tremendous toll in disability and societal cost. As our population ages, AD and other memory disorders will become increasingly prevalent. Patients and their… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will investigate the rapid deployment of wireless networks for the purpose of device-free localization (DFL) in tactical through-building surveillance applications. DFL locates people inside of a building using only simple radio devices… more
Abstract:This Small Business Innovation Research Phase I project creates GeniStress Responder. GeniStress Responder is part of EkaTox, a family of toxicology diagnostics harnessing the power of comparative genomics in nematodes to make toxicology predictions in humans. GeniStress Responder identifies and… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to address the educational needs of children at risk of reading failure in early grades, and specifically, to provide technology-based reading instruction, adaptive instructional strategies, ongoing curriculum-embedded assessments… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project seeks to demonstrate the technical and commercial viability of wireless instrumentation and smartphone technology used for feedback to amputees about their real-time performance for ubiquitous rehabilitation in situ. The goal is to… more
Abstract:ABSTRACT: Regulated heavy metals are typically removed from industrial wastewater through a metal hydroxide precipitation and sedimentation process. Complicating the treatment of these waste streams is the presence of commingled chemicals such as detergents, surfactants and other chelating… more
Abstract:DESCRIPTION (provided by applicant): Lower respiratory tract infections (LRTI), including pneumonia, are a significant threat to human health. For example, community-acquired pneumonia and influenza are together the seventh leading cause of death in the United States. There is a wide range of… more
Abstract:DESCRIPTION (provided by applicant): Mesodissection Device Microscopic analysis of tissue mounted on glass slides is commonly used to study cancer, nonneoplastic entities such as heart disease and diabetes, and normal cell function. At a growing rate, researchers are utilizing various micro and… more
Abstract:DESCRIPTION (provided by applicant): Microscopic examination of formalin fixed, paraffin embedded (FFPE) tissue sections mounted on glass slides is the cornerstone of clinical histopathology. Ancillary molecular testing is often required for diagnosis, risk stratification, ad treatment planning,… more
Abstract:DESCRIPTION (provided by applicant): Postmenopausal osteoporosis is a more dangerous disease than previously thought and is one of the most common diseases in older women. One in two women over age 50 will have an osteoporosis-related fracture during their lives, and fractures in postmenopausal… more
Abstract:TP-0413 is a novel small molecule inhibitor of the BMP pathway that has significant potential to be developed to treat anemia of cancer. Anemia of cancer is cytokine driven and results in the up-regulation of a liver hormone called hepcidin through the function of BMP receptors. Increased hepcidin… more
Abstract:The NASA application requires a system that can generate 3D images of non-metallic material when access is limited to one side of the material. The objective of this proposal is to demonstrate the feasibility of developing and build a new, practical, potentially portable, battery operated,… more
Abstract:DESCRIPTION (provided by applicant): The array technology developed by Normann et.al. two decades ago at the University of Utah is currently being manufactured and marketed to the neuroscience research community by Blackrock Microsystems (formerly known asCyberkinetics, Inc., CKI). The Utah… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop an innovative process which can transform conventional cemented tungsten carbide (WC-Co), the most widely used industrial tool material, into functionally graded cemented tungsten carbide (FG WC-Co). Compared to the… more
Abstract:Autonomous Solutions, Inc. (ASI) has teamed with Johns Hopkins Universitys Laboratory for Computational Sensing and Robotics (LCSR) to continue its Phase I development of autonomous manipulation and grasping behaviors for robotic manipulators. The team will continue the Phase I effort to engineer a… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop an innovative, cost-effective, oil quality sensor that can detect when and how engine oil becomes degraded, as an integral part of a smart engine health monitoring system. Current sensors typically work only with a specific… more
Abstract:The United States is currently faced with unprecedented energy challenge. Petroleum prices have skyrocketed due to rising competition for energy resources from emerging economies. There is a significant need for processes that can produce hydrocarbons from renewable resources rather than petroleum.… more
Abstract:DESCRIPTION (provided by applicant): Drug safety is a major concern for people that taking medicines as well as pharmaceutical companies, regulatory bodies, and basic researchers. Drug induced phospholipidosis (DIPL) is an adverse reaction to cationic amphiphilic drugs (CADs) resulting in excessive… more
Abstract:ABSTRACT: The Air Force has identified a need for a high performance traveling wave tube amplifier (TWTA) that supports high data rate battlefield satellite communications (SATCOM) for the foreseeable future. We propose to develop a light-weight, power-efficient, compact TWTA capable of operating… more
Abstract:The Air Force has identified a need for an advanced traveling wave tube amplifier (TWTA) that supports future generations of broad bandwidth, efficient and linear military satellite and terrestrial communications. To address this need, InnoSys proposes to develop innovative solutions for advanced… more
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