Abstract:TP-0413 is a novel small molecule inhibitor of the BMP pathway that has significant potential to be developed to treat anemia of cancer. Anemia of cancer is cytokine driven and results in the up-regulation of a liver hormone called hepcidin through the function of BMP receptors. Increased hepcidin… more
Abstract:The NASA application requires a system that can generate 3D images of non-metallic material when access is limited to one side of the material. The objective of this proposal is to demonstrate the feasibility of developing and build a new, practical, potentially portable, battery operated,… more
Abstract:DESCRIPTION (provided by applicant): The array technology developed by Normann et.al. two decades ago at the University of Utah is currently being manufactured and marketed to the neuroscience research community by Blackrock Microsystems (formerly known asCyberkinetics, Inc., CKI). The Utah… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop an innovative process which can transform conventional cemented tungsten carbide (WC-Co), the most widely used industrial tool material, into functionally graded cemented tungsten carbide (FG WC-Co). Compared to the… more
Abstract:Autonomous Solutions, Inc. (ASI) has teamed with Johns Hopkins Universitys Laboratory for Computational Sensing and Robotics (LCSR) to continue its Phase I development of autonomous manipulation and grasping behaviors for robotic manipulators. The team will continue the Phase I effort to engineer a… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop an innovative, cost-effective, oil quality sensor that can detect when and how engine oil becomes degraded, as an integral part of a smart engine health monitoring system. Current sensors typically work only with a specific… more
Abstract:The United States is currently faced with unprecedented energy challenge. Petroleum prices have skyrocketed due to rising competition for energy resources from emerging economies. There is a significant need for processes that can produce hydrocarbons from renewable resources rather than petroleum.… more
Abstract:DESCRIPTION (provided by applicant): Drug safety is a major concern for people that taking medicines as well as pharmaceutical companies, regulatory bodies, and basic researchers. Drug induced phospholipidosis (DIPL) is an adverse reaction to cationic amphiphilic drugs (CADs) resulting in excessive… more
Abstract:ABSTRACT: The Air Force has identified a need for a high performance traveling wave tube amplifier (TWTA) that supports high data rate battlefield satellite communications (SATCOM) for the foreseeable future. We propose to develop a light-weight, power-efficient, compact TWTA capable of operating… more
Abstract:The Air Force has identified a need for an advanced traveling wave tube amplifier (TWTA) that supports future generations of broad bandwidth, efficient and linear military satellite and terrestrial communications. To address this need, InnoSys proposes to develop innovative solutions for advanced… more
Abstract:DESCRIPTION (provided by applicant): Epoch Telemetry System for Long-Term Monitoring of Biopotentials ABSTRACT Neonatal and childhood seizures can increase an individual's susceptibility for developing epilepsy later in life. Obtaining long-term continuous recordings of electrical events,… more
Abstract:DESCRIPTION (provided by applicant): Heparin and its derivatives block P- and L-selectin mediated metastatic spread of cancer in animal models, and they potently inhibit the matrix degrading enzyme heparanase. Moreover, several large clinical trials performed with heparin or low molecular weight… more
Abstract:DESCRIPTION (provided by applicant): Chronic gingival inflammation afflicts over half of all American adults and can progress to periodontal disease, eventually resulting in tooth loss. Periodontitis is initiated by bacterial infection of the gingival tissues through a subgingival microbial biofilm… more
Abstract:DESCRIPTION (provided by applicant): Painful bladder syndrome/interstitial cystitis (PBS/IC) is an indolent bladder disorder that has continued to be a debilitating disease with few truly effective treatment options. Inflammatory conditions that afflict the urinary bladder can lead to pelvic pain,… more
Abstract:ImSAR and BYU propose to use SAR/STAP/MIMO techniques to provide continous navigation in a GPS denied environment for UAS. The team has expertise in precision location of UAVs targets using a variety of methods inlcuding radar. BENEFIT: Commercial aviation and UAS missions that have become… more
Abstract:DESCRIPTION (provided by applicant): The goal of this translational SBIR program is to create a small, implantable system for recording myoelectric signals from residual and reinnervated muscles of individuals with forearm and other amputations. The signals will be wirelessly coupled to an external… more
Abstract:ABSTRACT: Weapon systems or other high value electrical systems within the US military are all subject to wiring faults and degradation. Additionally, weapon systems are kept in service longer because of shrinking defense budgets, further compounding the risks associated with wiring systems. The… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is on the development of a planar, highly compact, sodium-beta rechargeable battery using sodium-ion conducting beta alumina solid electrolyte disc (Na-BASE) sandwiched between a liquid sodium and a nickel chloride salt, (p-ZEBRA… more
Abstract:This small business innovation research is intended to develop a long-life, highly efficient O2-CO cogeneration system to support NASA's endeavors to pursue extraterrestrial exploration (Moon, Mars, and Asteroids/Phobos). The cogeneration system will be built using a Tubular, Negative… more
Abstract:Solid Oxide Fuel Cell (SOFC) technology promises to provide an efficient method by which electricity can be generated from coal-derived syngas, biofuels, and natural gas, while increasing energy security and reducing greenhouse gas emissions. The large capital costs attributed to the cathode low… more
Abstract:The materials and structures for fusion reactors must function for a long time in a uniquely hostile environment that includes combinations of high temperatures, reactive chemicals, high stresses, and intense damaging radiation. Manufacturing of components, particularly joining of materials, has… more
Abstract:ABSTRACT: Highly reliable power supply technologies are needed for future arming and fuzing system designs. These power supplies should be able to operate after a long dormant period of up to twenty years. A novel battery power supply is proposed for this purpose. The proposed battery utilizes a… more
Abstract:The sulfur content of JP-8 fuel varies in a wide range up to 3000 ppm and it is detrimental to a fuel cell based auxiliary power units. The concentration of sulfur must be closely monitored to allow the APU to fully function within specification. A highly selective solid-state electrochemical sensor… more
Abstract:This project develops an electronic-controlled version of the advanced hydraulic foot/ankle (MCI Foot) demonstrating the feasibility of the automatic adjustment of resistance throughout the range of motion. The advanced MCI Foot, especially the automatic-controlled version, contributes to the… more
Abstract:DESCRIPTION (provided by applicant): In the United States alone, sepsis affects approximately 700,000 patients and leads to death of over 210,000 people per year. Sepsis is a clinical syndrome that results from a complex interaction between host and infectious agents, and is characterized by… more
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