Abstract:This small business innovation research is intended to develop a long-life, highly efficient O2-CO cogeneration system to support NASA's endeavors to pursue extraterrestrial exploration (Moon, Mars, and Asteroids/Phobos). The cogeneration system will be built using a Tubular, Negative… more
Abstract:Solid Oxide Fuel Cell (SOFC) technology promises to provide an efficient method by which electricity can be generated from coal-derived syngas, biofuels, and natural gas, while increasing energy security and reducing greenhouse gas emissions. The large capital costs attributed to the cathode low… more
Abstract:The materials and structures for fusion reactors must function for a long time in a uniquely hostile environment that includes combinations of high temperatures, reactive chemicals, high stresses, and intense damaging radiation. Manufacturing of components, particularly joining of materials, has… more
Abstract:ABSTRACT: Highly reliable power supply technologies are needed for future arming and fuzing system designs. These power supplies should be able to operate after a long dormant period of up to twenty years. A novel battery power supply is proposed for this purpose. The proposed battery utilizes a… more
Abstract:The sulfur content of JP-8 fuel varies in a wide range up to 3000 ppm and it is detrimental to a fuel cell based auxiliary power units. The concentration of sulfur must be closely monitored to allow the APU to fully function within specification. A highly selective solid-state electrochemical sensor… more
Abstract:This project develops an electronic-controlled version of the advanced hydraulic foot/ankle (MCI Foot) demonstrating the feasibility of the automatic adjustment of resistance throughout the range of motion. The advanced MCI Foot, especially the automatic-controlled version, contributes to the… more
Abstract:DESCRIPTION (provided by applicant): In the United States alone, sepsis affects approximately 700,000 patients and leads to death of over 210,000 people per year. Sepsis is a clinical syndrome that results from a complex interaction between host and infectious agents, and is characterized by… more
Abstract:DESCRIPTION (provided by applicant): HIV/AIDS remains a formidable global epidemic with 33 million infections worldwide, including over 1 million patients in the US. In 2008, there were 2.7 million new infections and 2 million AIDS-related deaths. CurrentHIV treatment combines drugs from several… more
Abstract:There is a growing need for new SPM techniques that provide additional information about the sample with higher data rates. In microwave harmonic scanning tunneling microscopy (MHSTM) a microwave signal is coupled to the STM, and several harmonics that are generated by the nonlinearity of the… more
Abstract:Coal gasification plants have exhibited sub-par performance and plant economics due to poor reliability and availability. A major contributor to the poor performance has been fouling of the syngas cooler located downstream of the gasifier. The fouling is due to vaporized ash from the coal… more
Abstract:The objective of the proposed Phase II STTR effort is to develop a validated computational tool to predict the afterburning of non-ideal munitions containing metal and hydrocarbon fuels. The activities outlined devise a well-coordinated collaboration among researchers from Reaction Engineering… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will investigate the feasibility of implementing new slow-wave circuits and electron beam confinement innovations for terahertz frequency backward-wave oscillators. A backward wave oscillator emits high- frequency radio waves, tuned by… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase II STTR project is to develop a real-time label-free biosensor that can analyze 96 samples at a time, compared to the 6 samples possible with current technologies. This platform will initially bedemonstrated with G-protein-coupled receptors… more
Abstract:ABSTRACT: Building on the demonstrated in Phase-I success of application of molecular dynamics (MD) simulations for investigation of hypergolic and non-hypergolic ionic liquid(IL)-based fuels, we propose to develop and validate a set of simulation tools and empirical correlations that will allow to… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project seeks to demonstrate that 840 nm spectral domain optical coherence tomography (OCT) can provide images equal to or better than those currently available from swept source OCT, with the added advantages of higher imaging speeds and lower… more
Abstract:Thermal control systems are one of the large hurdles in the development of rapidly deployed spacecraft. The solicitation discusses the goal of achieving a 6-day mission capability from initial request. This ambitious task will require a thermal management system that is flexible, modular and is… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to design and build a running prototype of a Directed Search and Training Engine to Educate and Support Entrepreneurs. Entrepreneurs have the opportunity to create profitable, society changing companies with high quality jobs, but… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop new sensor materials for detection of trace mercury in water systems, based on a patent-pending technique licensed by MetalloSensors. This technique at its current stage provides both high sensitivity (with detection limit… more
Abstract:DESCRIPTION (provided by applicant): This Phase I application requests funds to support the continued preclinical evaluation of a novel opioid analgesic, PPL-103, and the synthesis and initial preclinical evaluation of a series of new analogs thereof.PPL-103, a potent analgesic, has undergone… more
Abstract:DESCRIPTION (provided by applicant): This Phase I proposal details the rationale and the research plan for the synthesis and characterization of targeted, backbone degradable, long-circulating polymer conjugates containing two anticancer drugs per macromolecule. The polymeric carrier will be… more
Abstract:DESCRIPTION (provided by applicant): Percutaneous coronary intervention (PCI) is the most frequently employed strategy to revascularize atherosclerotic stenosis of native coronary arteries and saphenous vein grafts. Tissue perfusion is frequently impairedfollowing PCI, particularly in patients with… more
Abstract:DESCRIPTION (provided by applicant): Competing Continuation Grant Application Physiologic Controller for Rotary Blood Pumps Rotary blood pumps are rapidly gaining favor in the field of mechanical circulatory support because of their small size, reliability, and energy efficiency. However the… more
Abstract:DESCRIPTION (provided by applicant): The ADE Discoverer is an initiative to harvest adverse drug effects (ADEs) casually reported in forum discussions, user reviews, and other social media. Initially, the Discoverer will focus on a limited number of health-care related websites; however, as Phase I… more
Abstract:DESCRIPTION (provided by applicant): Modern ionizing radiation technologies incorporated into imaging Xrays, or fluoroscopy, and CT scanners have revolutionized diagnostic radiology. However, along with the benefits these technologies bring, there is a great concern regarding radiation exposure from… more
Abstract:Silicon Technologies, Inc. proposes to revolutionize Semiconductor Deep sub micron design capabilities by creating a new design tool called PLUG (Physical Logic Using Gratings). PLUG will be used to design analog and digital systems at 45 nanometers and below that will improve the productivity of… more
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