Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to design and build a running prototype of a Directed Search and Training Engine to Educate and Support Entrepreneurs. Entrepreneurs have the opportunity to create profitable, society changing companies with high quality jobs, but… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop new sensor materials for detection of trace mercury in water systems, based on a patent-pending technique licensed by MetalloSensors. This technique at its current stage provides both high sensitivity (with detection limit… more
Abstract:DESCRIPTION (provided by applicant): This Phase I application requests funds to support the continued preclinical evaluation of a novel opioid analgesic, PPL-103, and the synthesis and initial preclinical evaluation of a series of new analogs thereof.PPL-103, a potent analgesic, has undergone… more
Abstract:DESCRIPTION (provided by applicant): This Phase I proposal details the rationale and the research plan for the synthesis and characterization of targeted, backbone degradable, long-circulating polymer conjugates containing two anticancer drugs per macromolecule. The polymeric carrier will be… more
Abstract:DESCRIPTION (provided by applicant): Percutaneous coronary intervention (PCI) is the most frequently employed strategy to revascularize atherosclerotic stenosis of native coronary arteries and saphenous vein grafts. Tissue perfusion is frequently impairedfollowing PCI, particularly in patients with… more
Abstract:DESCRIPTION (provided by applicant): Competing Continuation Grant Application Physiologic Controller for Rotary Blood Pumps Rotary blood pumps are rapidly gaining favor in the field of mechanical circulatory support because of their small size, reliability, and energy efficiency. However the… more
Abstract:DESCRIPTION (provided by applicant): The ADE Discoverer is an initiative to harvest adverse drug effects (ADEs) casually reported in forum discussions, user reviews, and other social media. Initially, the Discoverer will focus on a limited number of health-care related websites; however, as Phase I… more
Abstract:DESCRIPTION (provided by applicant): Modern ionizing radiation technologies incorporated into imaging Xrays, or fluoroscopy, and CT scanners have revolutionized diagnostic radiology. However, along with the benefits these technologies bring, there is a great concern regarding radiation exposure from… more
Abstract:Silicon Technologies, Inc. proposes to revolutionize Semiconductor Deep sub micron design capabilities by creating a new design tool called PLUG (Physical Logic Using Gratings). PLUG will be used to design analog and digital systems at 45 nanometers and below that will improve the productivity of… more
Abstract:ABSTRACT: Select Engineering Services (SES) is a leader in developing, testing, and implementing frangible structures for airfield use worldwide. We have developed a large range of composite structures to improve the performance and quality of Air Force assets while decreasing costs to maintain… more
Abstract:ABSTRACT: Select Engineering Services (SES) is a successful provider of engineering and technical services to Air Force and Army customers; including system design, development, testing, and sustainment of complex tactical shelter and energy systems. Over the past nine years, SES has been… more
Abstract:The project will develop a novel generator that will allow the simultaneous generating of regulated voltages and currents. The new generator will use a newly developed magnetic design technology that can yield high output power and efficiency with conventional magnet materials such as ferrite or… more
Abstract:The objective of this project is to develop a methodology for predicting reaction violence of full-scale munitions in either a fast or slow cook-off scenario. This methodology will use a combination of existing heat transfer models and thermal stimulus simulation tools coupled with an empirical… more
Abstract:DESCRIPTION (provided by applicant): Despite notable achievements over the past two decades, cancer remains a challenging 21st century epidemic demanding new, more effective drugs. Nitric oxide (NO) is well known to kill cancer cells without harming norma
l bone marrow cells, but until now has not… more
Abstract:The overall objective of the proposal is to design, develop and demonstrate a potentially portable Compton x-ray scatter 3D-imaging system by using specially designed rotationally movable x-ray source and x-ray detector, and the development of a suitable 3D-processing computer model.
The proposed… more
Abstract:The nation is currently faced with the significant challenge of developing alternative sources of energy to meet our growing energy needs in a sustainable and environmentally responsible manner, while reducing carbon emissions. For a significant population of the western United States and the world… more
Conventional approaches to ocean energy are unlikely to make a material impact on global energy supply. HiFunda LLC and its affiliate Oscilla Power, Inc. are developing a utility-scale wave energy harvester enabled by low cost, domestically-and readily-available… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop new and improved materials for a novel wave energy device. We have developed a patent-pending concept for a no-moving-parts wave energy harvester that uses low-cost magnetostrictive alloys. This technology shows promise as… more
Abstract:In this SBIR project MagiCom proposes several innovative concepts to provide high speed, in-flight communication links between the Ballistic Missile Defense System (BMDS) Fire Control and Interceptor/Kill Vehicles such as the Ground Missile Defense - Exoatmospheric Kill Vehicle (GMD-EKV) and other… more
Abstract:DESCRIPTION (provided by applicant): This project addresses the process development and evaluation of an extremely flexible, Parylene C, micro-ribbon cable that is both biocompatible and biostable. Such a cable would be employed to link micro-electrode arr
ays with percutaneous connectors as well as… more
Abstract:DESCRIPTION (provided by applicant): Natural products are still the majority of therapeutic agents. However, they suffer from a difficulty in the creation of derivatives, and they can also be hard to supply. Derivatives are extremely important in the optim
ization of properties, such as toxicity or… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop an innovative process to significantly enhance the manufacturability of functionally graded cemented tungsten carbide (FGM WC-Co) by utilizing a high temperature carburization process. This technology is based on the… more
Abstract:Toxic compounds are a major health hazard in our environment, in our food, and in our pharmaceuticals. Identifying toxic compounds is currently time-consuming, expensive and complicated by animal rights issues. We propose to generate a set of 96 transgenic nematodes that will contain… more
Abstract:Shallow lagoon systems are the most common form of engineered domestic wastewater treatment in the United States and the world. Municipalities, particularly smaller rural communities, use this low cost treatment method. These lagoon systems are generally effective at reducing biochemical oxygen… more
Abstract:Rural farming communities, rural homeowners, the farmers, the small business/industries, the schools, and the municipalities need quality alternative energy solution to help offset all or a portion of their electrical power usage. In many instances the high cost of energy prohibits economic recovery… more
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