Abstract:DESCRIPTION (provided by applicant): Insufficient oxygenation of the blood (hypoxemia) is a common symptom in ICU patients, and may be caused by a combination of four different pathologies: 1) decreased alveolar ventilation (hypoventilation), 2) oxygen dif
fusion limitation, 3) inequality in… more
Abstract:DESCRIPTION (provided by applicant): In our Phase 1 application, we described an endothelial specific receptor, Robo4, that is expressed in mature vessels and is upregulated following endothelial injury. Robo4, following activation by its protein ligand, S
lit2, reduces agonist induced vascular leak… more
Abstract:DESCRIPTION (provided by applicant): Influenza infection leads to a cytokine storm as the host's immune system fights the virus. This combination of immunity factors has the unfortunate side effect of creating vascular leak. In the case of influenza patien
ts, this vascular leak most often occurs in… more
Abstract:The objective of this project is to develop a strategy to recover micro air vehicles into a flying aircraft. Our solution combines three key technologies that have received significant research attention in recent years, namely towed cable systems, cooperative control, and vision-based terminal… more
Abstract:The primary objective of the proposed effort is to develop a validated computational tool to predict the afterburning of non-ideal munitions containing metal and hydrocarbon fuels. The activities outlined devise a well-coordinated collaboration among researchers from Reaction Engineering… more
Abstract:Investigations into JP-10 combustion chemistry thus far can be characterized as preliminary. The detailed chemical kinetic mechanisms that have been published are limited in their ability to reproduce experimental data. The combustion chemistry of JP-10 is highly complex, involving hundreds if not… more
Abstract:The proposed project will leverage REI's experience creating and applying reduced chemical kinetic mechanisms for JP-8 with source-term speed-up techniques such as in-situ adaptive tabulation (ISAT) and artificial neural networks (ANN) to develop techniques for speeding evaluation of JP-8 kinetics… more
Abstract:With the current state of world events, the threat of buried explosives used against military vehicles is more pronounced than ever before. The introduction of the MRAP and MTVR vehicles have helped mitigate this threat to a degree, but military personnel continue to suffer from both death and… more
Abstract:Natural gas, which is predominantly methane, is widely used by industry as a chemical feedstock and as a fuel for power generation. The increasing price and diminishing domestic supply of natural gas creates an incentive to develop a low-cost replacement for the fuel. Coal gasification is one… more
Abstract:OBJECTIVE: Develop a fast running Computational Fluid Dynamics (CFD) Finite Element code taking advantage of hardware and software technologies developed in the gaming industry. The CFD code will be used to model highly non-linear and dynamic external blast events in urban settings and internal… more
Abstract:Coal gasification plants have exhibited sub-par performance and plant economics due to poor reliability and availability. A major contributor to the poor performance has been fouling of the syngas cooler located downstream of the gasifier. The fouling is due to vaporized ash from the coal… more
Abstract:Composite materials utilizing graphite fibers can exhibit high axial thermal conductivities. However, thermal conduction perpendicular to the fiber direction in the composite is extremely low due to the acoustical mismatch between the carbon fiber and epoxy. Sommer Materials Research, Inc.… more
Abstract:A need for miniaturized mass spectrometer (MS) instrumentation exists for both stationary point monitoring and applications where instrument size is critical, including military swatch test monitoring of chemical agent permeation rates and field detection of chemical agents. A 50% size and weight… more
Abstract:The objective of this work is to provide guidance to explosive formulators and facilitate the development of improved penetrator explosives. Because of the complexity of these materials, it is difficult to relate parameters controllable during formulation to desirable properties in the final product… more
Abstract:Thermal Management Technologies (TMT) will team with Utah State University"s Space Dynamics Laboratory to design, model, build, test, and demonstrate a full scale engineering prototype of an isothermal satellite bus enabled by TMT"s proprietary Channel Panel heat spreader technology and… more
Abstract:DESCRIPTION (provided by applicant): This Phase I proposal details the rationale and the research plan for the synthesis and characterization of a polymeric delivery system that will deliver two anticancer drugs with diverse mechanisms of action simultaneously into ovarian cancer cells. The delivery… more
Abstract:DESCRIPTION (provided by applicant): In this Phase II STTR project, Vestan Medical Imaging, Inc. will complete the development and clinical evaluation of its proprietary formulation of a fluorescent drug and new medical devices for Sentinel Lymph Node (SLN) biopsy for the surgical treatment of… more
Abstract:To improve safety and efficiency on high-speed signalized intersections a dilemma zone protection system has been designed to automatically configure site-specific protection boundaries on both main-street approaches by continously tracking vehicles within up to 1000 feet of each stop line. … more
Abstract:Wavetronix currently sells the SmartSensor HD radar detection which is the highest performance above ground detector currently available. However, the count, speed and classification accuracy can be significantlly improved by employing multi-beam radar technology which we have recently… more
Abstract:This Small Business Innovation Research Phase I research project involves the development of inexpensive, reconfigurable force-reflective telerobotic manipulators. Incorporating dexterous manipulators onto available mobile robotic platforms greatly expands the capabilities and usefulness of the… more
Abstract:During Phase I, goals of initial design and demonstration of system concepts for a portable friction stir welding (FSW) system were successfully completed. During Phase II, the objective is to design, fabricate, and demonstrate a portable and versatile FSW system. To support AMP's design, BYU will… more
Abstract:A battery is proposed that utilizes a Li+ conducting, solid-electrolyte separator, LiSICON, Li metal anode and high-capacity cathode. The LiSICON ceramic is fabricated using state of the art tape casting methods which allows composite structures of porous and dense layers ~100fYm thick. The layered… more
Abstract:The proposed research will develop a probabilistic decision analysis methodology and software framework applicable to Chemical, Biological, Radiological and Nuclear (CBRN) threats and incidents. The software prototype developed in the Phase I research will include tools to enable probabilistic… more
Abstract:U.S. and world petroleum supplies are limited, causing substantial increases and fluctuations in the cost of liquid fuels and national energy insecurity. If the vast western oil shale reserves could be economically and cleanly recovered, the country¿s transportation fuel problems would be… more
Abstract:Compositex, Inc. proposes to continue the development of a promising new material and fabrication technology for high performance motor cases and propellant tanks. This process using readily-available, low-cost, domestically-produced, environmentally-friendly thermoplastic raw materials. High-cost… more
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