Abstract:Many activities and technological systems prevalent in today’s society – air traffic control and air travel, the power grids, communications, deep-water drilling operations, human spaceflight – are vulnerable to the effects of sudden flares from our Sun. Because the propagation speed for… more
Abstract:ABSTRACT: Coordinate Registration (CR) of OTHR targets requires accurate real-time ionospheric modeling coupled with HF propagation calculations to convert radar-measured target signal delays and beam steers to geographical position. Our team is the developer of one of the most sophisticated… more
Abstract:OMAX proposes to develop an abrasive-waterjet (AWJ) system for drilling angled shaped holes in TBC-coated metals and engine components. Waterjet technology has technological and manufacturing merits that are unmatchable by many existing machine tools. In particular, OMAX will take advantage of… more
Abstract:Refractory alloys such as tantalum-tungsten and ceramics are being pursued as a solution to high temperature erosive wear of gun barrels. However rifling of these materials with conventional broaching and electrochemical milling is proving to be difficult. This proposal seeks to demonstrate an… more
Abstract:DESCRIPTION (provided by applicant): New therapies are desperately needed to relieve patients with Type 1 diabetes from the neuropathy, nephropathy and retinopathy associated with the current standard of treatment, injected insulin. Transplantation of pancreatic islet -cells, in combination with… more
Abstract:DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is characterized by brain amyloid plaques consisting of insoluble beta-amyloid protein (A?), and neurofibrillary tangles (NFTs) containing aggregated tau protein. AD drug discovery efforts havebeen largely focused on reducing brain… more
Abstract:We propose to develop an active sensor for in situ measurement of the inherent optical properties (IOPs) absorption and backscattering at multiple wavelengths. Multi- or hyper-spectral absorption of particles and dissolved materials is routinely measured in the laboratory and in situ in order to… more
Abstract:NASA missions for planetary exploration require high power, long-life Hall thrusters. However, thruster power and lifetime are limited by the erosion of plasma channel walls. Current plasma channel insulator materials, such as BN or Borosil, have the required low secondary electron emission (SEE)… more
Abstract:Conventional dielectric materials for radomes and windows for supersonic/hypersonic tactical missiles exhibit a number of performance limitations including inadequate thermal shock resistance, variations in electrical (dielectric constant and loss) and structural performance (mechanical strength)… more
Abstract:Carbon-fiber reinforced silicon carbide matrix (SiC/Cf) composite was identified as the leading thruster construction material for SDACS for SM3-Block IIB. For SDACS propulsion applications, SiC/Cf composite surfaces must be hermetically sealed and SiC/Cf composite must be joined to each other and… more
Abstract:Heritage vehicles with large, axial thrust rocket motors have used extendable nozzles with great success. The Ballistic Missile Defense System (BMDS) future interceptors, including the SM-3 Block IIB, require advanced DACS to evolve the BMDS toward emerging threats. Building upon its core… more
Abstract:Systima Technologies, Inc. (Systima) is developing an end-to-end integrated All-Up-Round (AUR) canister to provide a multiple missile launcher (MML) for Extended Area Protection & Survivability (EAPS) missiles. By allowing a single MML-AUR to provide up to 8 EAPS missiles the number of… more
Abstract:Systima in collaboration with the University of Washington will develop a high performance, advanced green monopropellant microthruster (0.1?1.0 N) for small- and micro-satellites. The microthruster utilizes a high energy density HAN-based monopropellant AF-M315E, and a novel injection system to… more
Abstract:Systima will develop an innovative light weight self-pressurizing pump (SPP) technology to provide a constant-pressure supply of monopropellant to a spacecraft or tactical propulsion system. The SPP does not require a helium tank and higher operating pressure have a negligible impact on the system… more
Abstract:The research proposed under this effort is focused on addressing the need for improved real-time in-situ sensing approaches for monitoring radionuclide contamination in the soils surrounding waste disposal facilities. Specifically this proposal focuses on the development of an approach for detecting… more
Abstract:DESCRIPTION (provided by applicant): Current practice in the USA for inoperable esophageal cancer is a palliative treatment using metal stent for end-stage cancer patients. Outside the USA (especially in Far East countries including China and Korea), therehave been reported clinical benefits of… more
Abstract:DESCRIPTION (provided by applicant): Molecularly Engineered Biomaterials for Minimally Invasive Dental Treatment Molecularly-engineered biomaterials are an ideal candidate for minimally invasive dental preparations, caries removal, and other dental treatments, including cleaning in perigingival… more
Abstract:ABSTRACT: Modern military space systems use high specific impulse (Isp) propulsion systems to provide efficient station keeping and large delta-V orbital maneuvers. A multi-mode propulsion system utilizes a single propellant such as AF-M315E to provide high thrust as well as a 1000-4000 s Isp. By… more
Abstract:Ocean wave energy has the potential to support approximately 10% of domestic and global electricity demand. Despite considerable investment over the past decade, however, wave energy is unlikely to make a material contribution to domestic or global energy supplies unless new technologies with… more
Abstract:DESCRIPTION (provided by applicant): This Phase II SBIR builds upon the activities of R43-AT006634, VerOFy: A New Tool to Improve Productivity and Reduce Costs for Stress Research . Technology for an integrated sample collection system was developed whichnon-invasively measures salivary cortisol… more
Abstract:DESCRIPTION (provided by applicant): A safe and effective therapeutic for treatment of osteoarthritis (OA) represents a major unmet medical need. OA is the leading cause of disability in the US and pain is a predominant clinical feature. However, chronicuse of non-steroidal anti-inflammatory drugs… more
Abstract:DESCRIPTION (provided by applicant): To gain a comprehensive understanding of cellular structures and function, correlative light and electron microscopy has been widely utilized to facilitate the acquisition of both macroscopic view of the whole organismand the localization of single molecules or… more
Abstract:DESCRIPTION (provided by applicant): Each year over 2 million adolescents are arrested in the U.S., and many more (9-18 percent of all youth) engage in serious delinquent behavior, such as heavy drinking, illicit drug use, and school drop-out. The most effective interventions to address these… more
Abstract:DESCRIPTION (provided by applicant): In the proposed phase II NIH STTR funding opportunity (PA-12-089), LodeSpin Labs (LSL) is developing a magnetic nanoparticle tracer for use in Magnetic Particle Imaging (MPI), a disruptive new medical imaging technologycurrently being developed as a safe,… more
Abstract:DESCRIPTION (provided by applicant): With few exceptions, extensive characterization of signal pathway alterations in cancer, and advances in our capacity to identify potent modulators of distinct molecular targets, has not translated into breakthrough drugs. In a recent New York Times article (Nov.… more
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