Abstract:DESCRIPTION (provided by applicant): Many patients requiring stem cell transplantation for hematological malignancies are unable to find a suitable HLA-matched sibling or unrelated donor. Transplants using stem cells from umbilical cord blood provide an alternative for these patients, allowing… more
Abstract:Immunotherapy has emerged as a promising method to treat several cancers. In 2012 the FDA approved a new immunotherapy agent, ipilimumab, for metastatic melanoma. Ipilimumab activates T-cells and globally increases the adaptive immune response and resultsin an enhanced response to the cancer. In a… more
Abstract:This Small Business Innovation Research Phase II project focuses on the development of a high-yield fermentation route for the production of levulinic acid (LA). LA is one of the best-suited C5 building blocks for bio-refinery production due to higher value, broad applications, and likely quick… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project brings together computational enzyme design with systems biology to create a fully integrated platform for novel pathway designs. The approach chosen will combine specific databases and a novel pathway synthesis tool. This computational… more
Abstract:DESCRIPTION (provided by applicant): Allergy is a major cause of illness and disability with an estimated 40-50 million people afflicted in the US alone. AIT provides long-term benefits for the patient and its need for optimization creates a compelling business opportunity. There is a very strong… more
Abstract:Monitoring mercury contamination in groundwater, surface water, and other natural environments is challenging and expensive, and because samples have to be collected in the field and analyzed in a laboratory, there is a long delay before results are available. The expense of monitoring limits the… more
Abstract:In modern fusion concepts, inductive pickup loops are one of the primary magnetic diagnostics in tokamaks and small-scale concept exploration experiments. They are used in industries and laboratories that utilize and study low-temperature plasmas. Inductive pickup loops are capable of extremely… more
Abstract:Methods to reduce the turbulent viscous skin friction stand out as paramount to increasing the energy efficiency, and therefore the aerodynamic efficiency of supersonic aircraft. Eagle Harbor Technology (EHT) proposes to develop and optimize a MHD plasma injector, which will be used to efficiently… more
Abstract:Combustion of biomass, especially in small-scale applications, produces high emissions of particulate matter (PM) that have been linked to adverse health effects and global climate change. Current industrial particulate control solutions are prohibitively expensive for use in small scale biomass… more
Abstract:EOSPACE proposes developing a practical, very-wide-bandwidth electrical characterization technique based on advanced photonic signal processing. The characterization method only requires a high-speed mm-wave source and uses exclusively low-speed optical detection, eliminating the need for high-speed… more
Abstract:The objective is to develop a wideband, high-sensitivity, high RF power handling optical modulator suitable for use in low-noise microwave photonic links associated with military and commercial antenna applications. Specifically, the modulator will be designed to be highly-resistive to… more
Abstract:DESCRIPTION (provided by applicant): Treating patients infected with Human Immunodeficiency Virus-1 (HIV-1) is a substantial clinical challenge with evolving pharmaceutical drug and dosing options. Treatments should improve the health and quality of life for HIV-infected individuals by reducing… more
Abstract:Inexpensive biofuels are essential to the national economic and environmental stability of the United States. Pathways are well established to ferment sugars derived from biomass into fuels and bioproducts. However, there is a massive gap between the physical form of raw cellulosic biomass and the… more
Abstract:Size reduction, or comminution, is a fundamental processing step for lignocellulosic biomass feedstocks used as a raw material for conversion to biofuels. Grinding or milling of herbaceous materials such as corn stover, switchgrass, miscanthus and other biofuel feedstocks consumes a lot of energy,… more
Abstract:ABSTRACT: The goal of the Space Test Program is to enable the US Air Force to rapidly develop emerging space technologies by providing economical flight opportunities to increase a technology"s TRL. Over the past decade, the CubeSat form factor has emerged as an economical platform for testing… more
Abstract:Leveraging TUI's SWIFT software defined radio (SDR) architecture, we propose to develop a 100 Mbps downlink and intersatellite crosslink capability with ranging and timing synchronization capabilities to enable more sophisticated CubeSat and small satellite missions. This effort will focus on… more
Abstract:With the increased demand for and utility of nano- and micro-satellites, the demand for responsive, low-cost access to space has also increased. To meet this demand, multiple private companies are pursuing the development of nano- and micro-launch vehicles (NMLV). However, NMLV builders lack… more
Abstract:TUI proposes to develop and demonstrate a process for fabricating high-performance composite truss structures on-orbit and integrating them with thin film solar cell assemblies to enable the deployment of very large solar arrays with lower cost and increased power-per-mass than SOA array… more
Abstract:To enable future robotic exploration systems to have greater mobility, sensing, sampling, and communication capabilities on difficult terrain such as craters, cliffs, gullies, and skylights, Tethers Unlimited proposes to develop a "Sensing and Positioning on Inclines and Deep Environments with… more
Abstract:ABSTRACT: The Phase I Versatile Structural Radiation Shielding (VSRS) Effort has successfully demonstrated the feasibility of 3D printing multifunctional spacecraft structures with integral multi-layer, multi-material, minimum-mass radiation shielding. We developed novel space-compatible materials… more
Abstract:The quiet operation and high efficiency of fuel cells provide an ideal solution for portable electric power generation for a wide range of military and commercial applications. A compact and efficient fuel processor that provides hydrogen from multiple types of liquid fuels will allow fuel cell… more
Abstract:DESCRIPTION (provided by applicant): Animal models of disease are transforming preclinical research, allowing critical insights into disease mechanisms and evaluation of new therapeutics. While the utility and availability of animal models in research isswiftly expanding often the research tools… more
Abstract:Today"s high energy Q-switched Nd:YAG lasers are often pumped by stacks of multiple edge-emitting diode laser bars since the vertical-cavity surface-emitting laser (VCSEL) traditionally have been lower in efficiency. In this effort we are proposing a novel VCSEL design which overcomes the… more
Abstract:nLIGHT proposes a two dimensional Wavelength Stabilized Vertical External Cavity Surface Emitting Lasers (WS-VECSEL) as a pump source for Rb vapor alkali laser used in directed energy weapons. The integration of a narrow-band reflector (i.e. a volume holographic grating) into the external cavity… more
Abstract:nLight proposes the development of high efficiency, high average power 1550-nm laser transmitter system that is based on Er-doped fiber amplifier resonantly pumped by high efficiency 1532-nm fiber-coupled diode laser pumps. To meet the efficiency requirement for space communication, nLight proposes… more
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