Abstract:The inability to dynamically image materials at atomic resolution in changing liquid environments is a significant impediment to the advancement of physical, chemical, biological, medical, and material sciences. Hummingbird Scientific, via its liquid cell holders, has greatly enhanced the ability… more
Abstract:DESCRIPTION (provided by applicant): Remote monitoring of patients engaged in rehabilitation programs offers the potential of maximizing clinical outcomes and minimizing costs. With initial funding from a Coulter Translational Research Partnership in Biomedical Engineering and from the Washington… more
Abstract:DESCRIPTION (provided by applicant): Lung cancer is the most prevalent cancer worldwide and responsible for the most cancer deaths in the United States. Existing therapies include surgery, radiation, or chemotherapy to kill the tumor cells, but these options are not adequate for the vast majority… more
Abstract:DESCRIPTION (provided by applicant): Congenital heart disease (CHD) ranges from benign lesions to life-threatening structural abnormalities. While benign lesions may resolve without intervention, severe structural lesions require complex pediatric cardiacsurgery. The reconstruction of the aortic… more
Abstract:DESCRIPTION (provided by applicant): Silver Sulfadiazine (SSD) is the most widely used topical antimicrobial agent in the world and while effective against a wide variety of pathogens, i has been shown to delay wound healing. Formulation of SSD into creamsand gels with the inclusion of a… more
Abstract:DESCRIPTION (provided by applicant): Aminoglycoside antibiotics (AGs) are important for the treatment of a variety of serious infectious diseases including septicemia, complicated intra-abdominal infections, complicated urinary tract infections, and nosocomial respiratory tract infections. AGs are… more
Abstract:The broader impact/commercial potential of this project includes technological advancement for a wide range of telerobotic applications including and manipulation tasks in hazardous or remote environments, search and rescue, remotely operated construction and maintenance, mining, bomb disposal,… more
Abstract:DESCRIPTION (provided by applicant): Lyme disease, a tick-borne infection caused by the spirochete Borrelia burgdorferi, has expanded to an estimated 300,000 US cases per year. Currently approved tests of immune response are sub-optimal and often give negative results early in the disease. The… more
Abstract:We will develop and test a simulator of diagnostic vascular ultrasound for use in medical education and professional certification. The simulator will include not only two-dimensional (2D) images but also Doppler spectral waveforms to simulate duplex ultrasound scanning. The rationale is that… more
Abstract:Closed wind tunnel beamforming for aeroacoustics has become more and more prevalent in recent years. Still, there are major drawbacks as current microphone arrays are rather larger and hard to install and conventional beamforming and deconvolution techniques do not work well in low signal-to-noise… more
Abstract:The project team is developing a prototype of Eco, a multi-player game to prepare high school students to be environmentally literate citizens with 21st century skills. To play the game, students will enter a shared online world featuring a simulated ecosystem of plants and animals. Students will… more
Abstract:Polylactid acid (PLA) is a thermoplastic, aliphatic polyester derived from renewable resources, such as corn starch and other sugars. It has numerous environmental benefits, including a lower energy cost at the beginning of its life and biodegradability at the end of life, and it is used in food… more
Abstract:? DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will demonstrate the feasibility of using microbial induced calcite precipitation by indigenous soil bacteria to reduce the mobility of lead in contaminatedsoils and collect metal adapted ureolytic… more
Abstract:DESCRIPTION (provided by applicant): In this Phase I project Metheor Therapeutics is proposing a unique approach to developing novel DNA methyltransferase (DNMT) inhibitors, testing the concept of a substrate trap designed to capture and deplete the enzyme. Inhibition of DNMT activity is a validated… more
Abstract:This SBIR Phase I project proposes to design a robotics-based gaming system for Science, Technology, Engineering and Math (STEM) education that is attractive to girls. The hypothesis is that physical game-based learning from play patterns that revolve around a robot's storyline, with… more
Abstract:DESCRIPTION (provided by applicant): Minimal Residual Disease Monitoring by T-cell Receptor Repertoire Profiling T-cell neoplasms are generally more aggressive and have poorer outcomes than comparable B-cell lymphomas. In addition, for many of these patients, prognosis following disease relapse is… more
Abstract:DESCRIPTION (provided by applicant): Many patients requiring stem cell transplantation for hematological malignancies are unable to find a suitable HLA-matched sibling or unrelated donor. Transplants using stem cells from umbilical cord blood provide an alternative for these patients, allowing… more
Abstract:Immunotherapy has emerged as a promising method to treat several cancers. In 2012 the FDA approved a new immunotherapy agent, ipilimumab, for metastatic melanoma. Ipilimumab activates T-cells and globally increases the adaptive immune response and resultsin an enhanced response to the cancer. In a… more
Abstract:This Small Business Innovation Research Phase II project focuses on the development of a high-yield fermentation route for the production of levulinic acid (LA). LA is one of the best-suited C5 building blocks for bio-refinery production due to higher value, broad applications, and likely quick… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project brings together computational enzyme design with systems biology to create a fully integrated platform for novel pathway designs. The approach chosen will combine specific databases and a novel pathway synthesis tool. This computational… more
Abstract:DESCRIPTION (provided by applicant): Allergy is a major cause of illness and disability with an estimated 40-50 million people afflicted in the US alone. AIT provides long-term benefits for the patient and its need for optimization creates a compelling business opportunity. There is a very strong… more
Abstract:The Navy needs a metal cutting system for submarine and aircraft carrier hull disposal. We propose to develop a Hull Cutting Mill (HCM) to meet Navy needs. Our HCM uses a compact high-speed high-power hydraulic milling head to perform slot-milling and achieve a fast lineal speed cutting high-tensile… more
Abstract:ABSTRACT: We propose to develop for the Air Force a high-efficiency Waste Heat Removal System (WHRS) that removes large amounts of waste heat from aircraft with negligible impacts on signature and aerodynamic performance. Our WHRS absorbs heat from aircraft thermal loads, including a Thermal… more
Abstract:Monitoring mercury contamination in groundwater, surface water, and other natural environments is challenging and expensive, and because samples have to be collected in the field and analyzed in a laboratory, there is a long delay before results are available. The expense of monitoring limits the… more
Abstract:In modern fusion concepts, inductive pickup loops are one of the primary magnetic diagnostics in tokamaks and small-scale concept exploration experiments. They are used in industries and laboratories that utilize and study low-temperature plasmas. Inductive pickup loops are capable of extremely… more
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