Abstract:Americas transportation sector relies almost exclusively (94%) on refined petroleum products, accounting for over 70% of the oil used. Nearly 9 million barrels of oil are required every day to fuel the 247million vehicles that constitute the U.S. lightduty transportation fleet. Biomass from… more
Abstract:DESCRIPTION (provided by applicant): This fast-track proposal applies advanced kinetic image pattern recognition (KIPR) technologies to predict induced pluripotent stem cell (iPSC) reprogramming colonies' differentiation outcomes for significantly improvedyield and robustness of differentiation… more
Abstract:DESCRIPTION (provided by applicant): Significance: End Stage Renal Disease (ESRD) affects a rapidly growing population likely to exceed 1 million patients in the US by 2020. The standard treatment of 3 times per week hemodialysis (HD) has high complicationrates and infection risks, results in… more
Abstract:DESCRIPTION (provided by applicant): The primary goal of this proposal is to develop opioid peptide aerosol-compatible formulations and an intranasal drug delivery system to deliver mu/delta opioid peptides to the central nervous system (CNS) in effectiveconcentrations as the first step in… more
Abstract:We envision a class of miniature robotic aircraft dubbed Flexrotors which offer range, endurance, and economy at levels associated with wing-borne flight, together with capability for hover and fully-automated turnaround. Routine operations of these aircraft will include dynamic transitions between… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research project addresses the problem of biomarker detection in clinical and high-throughput data. The objective is to investigate new approaches for deter- mining, from data consisting of many possibly irrelevant or redundant… more
Abstract:This project will result in the creation of the DDIS, an online information resource bringing together data and analysis tools on drugged driving together with a searchable knowledge base of relevant intervention strategies.
Abstract:Multiform Harvest Inc. ("Multiform") produces the fertilizer struvite, which is magnesium ammonium phosphate hexahydrate. Multiform produces the struvite by extracting it from wastewaters containing excess phosphorus. Multiform sells into two markets: 1) wastewater generators who need to… more
Abstract:DESCRIPTION (provided by applicant): The current SBIR Phase I proposal addresses a need for the rapid and simple sample preparation of genomic DNA from human saliva and blood through a novel technology: microscale tip enrichment probes that employ electric fields and capillary action. With the… more
Abstract:To realize laser-driven inertial fusion energy with economically viable efficiency and repetition rates, pumping the laser system with semiconductor diode lasers instead of the flashlamp will be essential. Diode laser prices are currently much too high for practical implementation of fusion energy.… more
Abstract:nLight proposes to suppress the key remaining output power extraction limiter COMD failure mechanism by passivating the cleaved facet of laser diodes with high bandgap semiconductor layers that is epitaxially grown in an atomically conformal manner at low temperature and in ultra-high vacuum.
Abstract:nLight proposes a novel semiconductor laser device operating at ~976 nm with a spatially single mode laser that is separately addressable to generate a few hundred milliwatts of power and then subsequently amplified to>10 watts with a separate electrical contact in a larger gain area while… more
Abstract:Higher power wavelength-stabilized pump sources operating in the 78x-nm to 79xnm band are expected to enable high-energy CW laser systems based on low pressure alkali gasses (such as Cs or Rb). Under the proposed program, nLight will design, demonstrate, and deliver to the MDA (or recipient of their… more
Abstract:Improving efficiency as well as increasing operating temperature of laser diode pumps for high-power fiber lasers has a far-reaching implication in terms of significantly improving the overall stringent size, weight and power (SWAP) requirements, thus enabling DEW-class fiber lasers on airborne… more
Abstract:nLight proposes to develop and commercialize an innovative kilo-watt class fiber laser pump combiner which is especially suited for counter-pumping architectures that is indispensable for various coherent combining techniques. The key advantages of this proposed technology over the current… more
Abstract:nLIGHT will develop a novel fused fiber combiner capable of accepting standard-sized active fibers. This"over-sleeve"combiner is designed to leave the active fiber undisturbed, allowing for counter propagation pumping of the laser amplifier, while efficiently coupling multiple kilowatts of… more
Abstract:It is well known that satellite communications and radar signals propagating in the natural ionosphere can be disturbed. It has also been widely reported that the ionosphere is subject to even greater disturbances following nuclear detonations. Hence the design of robust satellite communications… more
Abstract:UHF radars at high latitude observe significant perturbations in measurements of amplitude, phase, range, and Doppler, caused by ionospheric disturbances. Without mitigation of these effects, there is no doubt that the natural ionosphere is a major issue in the performance of the important radar… more
Abstract:ABSTRACT: Coordinate Registration (CR) of OTHR targets requires accurate real-time ionospheric modeling coupled with HF propagation calculations to convert radar-measured target signal delays and beam steers to geographical position. Our team is the developer of the most sophisticated CR… more
Abstract:DESCRIPTION (provided by applicant): Pain affects over 100 million Americans annually. Opioids are the primary drugs that can treat pain. However, these drugs produce severe and unwanted side effects, such as respiratory depression, nausea, constipation and tolerance development (Berde et al, 2008);… more
Abstract:DESCRIPTION (provided by applicant): Monoclonal Antibodies for Orphan GPCRs in the CNS GPCRs comprise a large family of structurally related membrane proteins with critical functions in neurobiology. As such, they are key therapeutic targets. However, many members of the vast GPCR family remain… more
Abstract:DESCRIPTION (provided by applicant): The overall objective of the MASP-2 program is to develop a monoclonal antibody that blocks the function of MASP-2, in order to treat microvascular complications associated with diabetes. The goal of the work proposed in this application is to validate… more
Abstract:An efficient acoustic holography technique for characterizing the noise source of tactical aircraft jet plumes was developed through the bench testing stage in Phase I. A full-scale array of 100 microphone locations was designed to be able to capture the noise of an F-18 in a simulated carrier… more
Abstract:Refractory alloys such as tantalum-tungsten and ceramics are being pursued as a solution to high temperature erosive wear of gun barrels. However rifling of these materials with conventional broaching and electrochemical milling is proving to be difficult. This proposal seeks to demonstrate an… more
Abstract:Electroplated hard chrome is used extensively for aerospace and industrial applications because it is wear resistant, corrosion resistant, has a good surface finish and has good adhesion. Naval aircraft use chrome plating on landing gear components because of these characteristics. However these… more
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