Abstract:DESCRIPTION (provided by applicant): The fit of a prosthesis determines the function of the user to a great degree. In the extreme, a painful fit will result in non-use of the prosthesis. Diurnal, menstrual and other fluctuations in body weight lead to noticeable changes in comfort and function of… more
Abstract:DESCRIPTION (provided by applicant): Despite the success of TNF-inhibitors and other new biological drugs for the treatment of autoimmune and other chronic inflammatory diseases, there are still many patients that respond poorly. Suppressing NF-kB induction as treatment of chronic inflammatory… more
Abstract:Marine aquaculture production now exceeds 20 million metric tons annually (FAO 2010) but viral diseases are still a major threat to the expansion of sustainable mariculture systems (National Marine Fisheries Service 2007). Pathogenic viruses continue to devastate many fish and shellfish operations… more
Abstract:DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is characterized by brain amyloid plaques consisting of insoluble beta-amyloid (A2) and tau protein containing neurofibrillary tangles (NFTs). AD drug discovery strategies have been largelyfocused on reducing brain A2 levels,… more
Abstract:We propose a microwave microscopy for blade health measurement of aircraft engines at high temperature. Its designs will efficiently insulate the sensor components from the combustion heat without sacrificing the measurement sensitivity and accuracy. The microwave sensor is very sensitive to the… more
Abstract:The fleet presently has limited ability to safely and productively inspect condensers. Condenser failure can result in chloride contamination of the steam plant and loss of platform availability. The present inspection method depends on hard physical labor under unpleasant and hazardous conditions… more
Abstract:FAA and international standards require lighting of tall structures in order to warn aircraft of collision hazards. U.S. Navy VLF/LF towers have experienced an unacceptable rate of failure of existing tower lighting systems, resulting in significant maintenance costs and system downtime. QUEST… more
Abstract:Missile structures are trending toward greater use of composites materials thanks to its weight savings, mechanical properties, manufacturability and excellent performance under fire, meeting"insensitive munitions"criteria. However, composites are not immune to damages and accidental… more
Abstract:This SBIR Phase I program will identify the joining materials and demonstrate the processes that are suited for construction of advanced ceramic matrix composite (CMC) thrusters for advanced monopropellants and bipropellants for space propulsion. We will join CMCs to each other and to superalloys… more
Abstract:Currently available Aluminum nitridesilicon carbide (AlNSiC) composite lossy dielectrics are not suitable as high order mode (HOM) absorbers in superconductor radio frequency (SRF) cavities in linear accelerators operating at cryogenic temperatures. Even though they have favorable dielectric… more
Abstract:An innovative prototype tunable CO2 laser system with subnanosecond pulse duration and high peak power will be built and delivered for experiments on double-resonance remote sensing of gaseous chemical agents being conducted at the Army Aviation and Missile Research, Development, and Engineering… more
Abstract:ASSURE - Aeroelastic / Aeroservoelastic (AE/ASE) Uncertainty and Reliability Engineering capability - is a set of probabilistic computer programs for isolating uncertainties in simulation, manufacturing, test, measurement, and test to analysis correlation affecting the AE/ASE characteristics of… more
Abstract:Traveling sine waves can occur in an aerial refueling hose that result in excessive forces transferred to the receiving aircraft"s refueling probe. These waves can arise from failures in the hose reeling mechanism, high aircraft approach speeds, or other inputs that create excessive hose slack.… more
Abstract:DESCRIPTION (provided by applicant): SX-576 is a small molecule CXCR1/2 antagonist that potently blocks the migration of neutrophils to sites of injury and/or inflammation. SX-576 is being developed as a potential therapeutic for the treatment of pulmonaryinflammatory diseases, such as… more
Abstract:DESCRIPTION (provided by applicant): Mycobacterium tuberculosis (Mtb) is a notorious pathogen whose increasing resistance to antibiotics and heightened lethality in combination with AIDS makes it a major health concern worldwide. The selection and spread of multiple drug resistant Mtb continued for… more
Abstract:Systima is proposing to develop an end-to-end integrated solution to provide a high velocity, Long Range Ram Accelerator Mobile Field Howitzer (LRRAM-FH) system that will dramatically increase velocity and range capabilities over conventional artillery. The ram accelerator launcher will accelerate… more
Abstract:ABSTRACT: Systima is proposing a Phase II SBIR program for a Scramjet Cold-Start Gas Generator (SCS-GG). Systima"s concepts combine the advanced injection methods and advanced ignition propellants into a reliable, low weight and volume cold-start solution. During Phase II, Systima will mature… more
Abstract:DESCRIPTION (provided by applicant): The first goal of Healthy People 2010 is to help individuals of all ages increase life expectancy and improve their quality of life. Individuals with cystic fibrosis (CF), a life-shortening chronic disease affecting ~30,000 individuals in the U.S., suffer from… more
Abstract:DESCRIPTION (provided by applicant): Pain is the primary reason that people seek medical care. Unfortunately, under-treatment of pain is well- documented in cancer (Cohen et al, 2003; Deandrea et al., 2008) and other medical conditions (Boulanger et al., 2007; Hadjistavropoulos et al., 2006). While… more
Abstract:DESCRIPTION (provided by applicant): Disregulated angiogenesis-the growth of new blood-vessels from existing vasculature-plays a central role in more than 70 major health conditions including cancer, cardiovascular disease, and macular degeneration. More than one billion people worldwide are… more
Abstract:This proposal addresses the problem of long term mapping and monitoring of subsurface geochemical and microbial activity associated with the transport and remediation of subsurface contaminants, including radionuclides and metals. The ability to map and monitor bioremediation processes in the near… more
Abstract:This proposal addresses the problem of measuring and mapping saturated hydraulic conductivity in the top 100 m of the subsurface. Hydraulic conductivity is a critically important property controlling groundwater and contaminant movement. The ability to measure and map hydraulic conductivity in the… more
Abstract:DESCRIPTION (provided by applicant): The objective of this project is to develop a therapeutic strategy for H V-associated malignancy based on the role of HPV in the pathogenesis. HPV related cancers express the E6/E7 oncoproteins of HPV that are ideal targets for immune inducing vaccines. We will… more
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