Abstract:This Phase I, SBIR contract is for the development of a new vaccine targeting HER2/neu expressing breast cancers. The vaccine induces both cell-mediated and humoral immunity and the company is planning a first-in-man Phase I/Phase II clinical trial. It isanticipated that this new biotherapeutic… more
Abstract:Etubics Corporation is clinically testing a new vaccine targeting carcinoembryonic antigen (CEA) expressing cancers in a Phase I/II clinical trials under FDA IND14325. Many cancers express CEA, including colon, breast and pancreatic cancers. It is anticipated that this new biotherapeutic product… more
Abstract:The Electromagnetic Plasmoid Thruster (EMPT) is a revolutionary electric propulsion thruster and power processing (PPU) system that will allow a dramatic decrease in system mass and increase in thrust efficiency over traditional 500-3000 W propulsion systems. The high specific power (>700 W/kg)… more
Abstract:The Electromagnetic Plasmoid Thruster (EMPT) program demonstrated a next generation propulsion system based on the purely electromagnetic generation and Lorentz acceleration of a magnetically self-confined plasmoid. The Peristaltic Dynamic Acceleration (PDA) stage is an addition to the exhaust of… more
Abstract:The Electromagnetic Plasmoid Thruster (EMPT) has demonstrated the ability to ionize, electromagnetically accelerate, and eject a broad range of complex and chemically-reactive molecular gases, including monopropellants. EMPT has the potential to dramatically increase the operational range of… more
Abstract:BlueView Technologies, working with the Applied Physics Laboratory at the University of Washington propose to research and develop the application of high frequency imaging sonar to the problem of sea ice thickness and morphology. The use of compact, low power sonar systems in modern Unmanned… more
Abstract:Doppler velocity logs (DVLs) are an essential component of any integrated autonomous underwater navigation system but the size, weight and cost is not compatible with the small AUVs foreseen for riverine and coastal surveys. The research objective is to develop a small wideband DVL (WB-DVL) which… more
Abstract:Automated techniques for harvesting knowledge from documents will make tasks like intelligence gathering significantly faster and more reliable. Information in documents is often distributed between text and non-textual components, which rely upon each other to create a comprehensive picture of what… more
Abstract:Future NASA exploration plans will realize significant performance advantages with aerocapture and aerobraking of large, heavy payloads for Mars, Titan, and the gas giant planets. During a previous NASA LaRC funded High Mass Mars Entry System study, Andrews Space found that while inflatable… more
Abstract:Lightning Ridge Technologies, working in collaboration with The Innovation Laboratory, Inc., extend Automatic Dependent SurveillanceÂ? Broadcast (ADS-B) into a safe, secure, authenticated system. Historically, ADS-B has been criticized for its inability to guarantee safe and secure surveillance in… more
Abstract:Lightning Ridge Technologies advances the state of the art of Controlled Reception Pattern Antennas (CRPAs) for rotorcraft by developing an adaptive beamsteering technology to significantly mitigate hostile jamming while estimating and cancelling GPS signal variations that plague rotorcraft… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project extends the development and enhances the flexibility of a screen-based, medical physiology, computer simulation design that engages students in an active learning process. Reduced availability of live animal laboratory instruction and… more
Abstract:This SBIR Phase I research proposal proposes research to develop an ultra-compact, low cost system for wirelessly monitoring motors that will cost manufacturers less than $300/ motor to implement. The research will leverage existing patent-pending energy-efficient algorithms for determining motor… more
Abstract:DESCRIPTION (provided by applicant): This phase I SBIR application investigates the feasibility of using surgical mesh composed of novel timed-release fibers to controllably contract and provide support to pelvic organs with the long term goal of correcting pelvic floor disorders (PFDs) in elderly… more
Abstract:DESCRIPTION (provided by applicant): This Phase 1 NIH SBIR proposal is for support of an interdisciplinary program involving the Oasis Diagnostics(R) Corporation, Madison Biodiagnostics, LLC, and the University of New Orleans who seek to collaboratively demonstrate an innovative saliva collection… more
Abstract:DESCRIPTION (provided by applicant): The funding of the application will yield safety and efficacy data on a new combination cancer therapy for leukemia and lymphomas. Monoclonal antibodies (mAbs) have emerged as a class of novel oncology therapeutics. Weare developing a molecule that can improve… more
Abstract:DESCRIPTION (provided by applicant): Title: Analgesics Targeting TRPA1 for Treatment of Chronic Pain Abstract An effective treatment for chronic pain that is devoid of both addictive potential and abuse liability is a major unmet need in medicine today. These limitations drive the need for… more
Abstract:DESCRIPTION (provided by applicant): The ultimate technical objective of this research is the development of an Artificial Pancreas (AP) controller that improves metabolic control and decreases glycemic excursions by robustly preventing hypoglycemic episodes. Proportional-integral-derivative control… more
Abstract:DESCRIPTION (provided by applicant): To gain a comprehensive understanding of cellular structures and function, correlative light and electron microscopy has been widely utilized to facilitate the acquisition of both macroscopic view of the whole organismand the localization of single molecules or… more
Abstract:DESCRIPTION (provided by applicant): Our ultimate goal is to build PracticeGround, a commercially successful online platform that has the potential to improve outcomes for patients receiving mental health treatment by increasing practitioners' implementation of evidence-based practices (EBPs)… more
Abstract:DESCRIPTION (provided by applicant): Magnetic Resonance Imaging (MRI) is an attractive platform for medical imaging because it uses neither harmful radiation nor expensive radio-tracers; however, MRI, even with the aid of suitable contrast agents, is plagued by background noise from the host tissue… more
Abstract:DESCRIPTION (provided by applicant): The goal of this proposal is for Matrexa to develop a protein product that will prevent intimal hyperplasia in human saphenous vein grafts (SVG) with the objective of reducing the exceedingly high failure rate of thesesurgical procedures. The strategy involves… more
Abstract:DESCRIPTION (provided by applicant): The physical fitness and strength requirements for lower limb amputee gait are so high that thirty-seven percent of amputees are unable to walk with a prosthesis and another twenty-three percent are able to ambulate indoors only. Recent advances in prosthetic… more
Abstract:DESCRIPTION (provided by applicant): Hydrocephalus is the inability to reabsorb spinal fluid and arises in the setting of various disease states leading to approximately 75,000 shunt insertions/revisions annually in the U.S. The basic technique of ventricular shunting has remained essentially… more
Abstract:This proposal seeks to develop a cancer diagnostic based on microRNA (miRNA) expression patterns found in human serum. Mounting evidence is showing that patterns of miRNA expression and the appearance of these signals in circulating extra-cellular compartments are hallmarks of proliferating tumor… more
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