Abstract:ORBITEC, in collaboration with Lucigen, proposes a rapid genetic detector for spaceflight water systems to enable real-time detection of E. coli with minimal consumables and crew time. The Rapid Coliform Detector (RCD) amplifies the genetic material in a liquid sample to allow near real-time… more
Abstract:ORBITEC proposes to develop non-toxic propulsion systems to replace hyradzine-derivative systems in interceptor applications. In ongoing work, ORBITEC has been developing high-performance ionic liquid fuels. These inherently non-volatile fuels promise safer, less sensitive systems while providing… more
Abstract:ABSTRACT: ORBITEC proposes to develop the Cooling Channel Diagnostic System (CCDS), a diagnostic tool for assessing the condition of rocket engine cooling channels. This system will be used to detect and locate any deposits which inhibit heat transfer between cooling channels and the hot-gas wall… more
Abstract:ABSTRACT: ORBITEC proposes to develop a hybrid cycle to improve the overall performance and reduce the cost of advanced upper stage engines. Upper stage engines using the High Performance Hybrid Cycle (HPHC) will have the benefits of compact design, high thrust-to-weight, and high Isp. Once… more
Abstract:ORBITEC proposes to develop the Advanced Reversible Cryogenic Thermal Energy Storage (ARCTES) system, which will provide temporary backup cooling for circulating helium gas coolant in high-temperature superconducting (HTS) systems for naval applications. The ARCTES will rely on an initially-frozen… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will lead to the development of a new class of liquid crystal (LC)-based direct-read monitors (DRMs) for detection of nitrogen dioxide (NO2) present in air at construction sites. The approach to development of DRMs that is described in… more
Abstract:DESCRIPTION (provided by applicant): Primorigen Biosciences SBIR Proposal Abstract Primorigen Biosciences will use SBIR funds to develop an advanced cell culturing methodology to increase the efficiency of directed differentiation and to boost functional maturity of induced pluripotent stem… more
Abstract:DESCRIPTION (provided by applicant): Primorigen Biosciences will develop an enhanced cell culturing technology that dramatically increases proliferative and differentiation capabilities of human bone-marrow derived mesenchymal stem cells (hMSC's) for neural induction, and ultimately for… more
Abstract:DESCRIPTION (provided by applicant): Schizophrenia is a chronic and debilitating disorder that impacts nearly 1% of the world's population. The burden on the families and caregivers of patients is immense, with the cost of care in the United States being greater than 60 billion annually. The… more
Abstract:DESCRIPTION (provided by applicant): Scarab Genomics has developed valuable reduced-genome strains of Escherichia coli in which multiple deletions remove from the genome much unwanted and all potentially hazardous DNA. These Clean Genome(R) strains, alongwith Scarab's gene expression technology… more
Abstract:DESCRIPTION (provided by applicant): Biotherapeutics is a fast-growth sector in the pharmaceutical market with monoclonal antibodies accounting for almost 50% of the 100 billion USD spent each year on protein therapies. Bacterial fermentation, which accounts for about 35% of all protein therapeutics… more
Abstract:DESCRIPTION (provided by applicant): In today's biopharmaceutical pipeline, monoclonal antibodies (mAbs) are a predominant modality for a broad range of clinical indications including oncology and inflammatory diseases. Most antibody therapies have to be administered to the patients in large… more
Abstract:Complex skin defects, including burns and trauma, represent a major medical problem affecting both military and civilian populations. In recent military engagements, burns account for approximately 5% of combat casualties. Furthermore, approximately 1.25 million Americans each year require medical… more
Abstract:DESCRIPTION (provided by applicant): The ultimate goal of this project is to develop an innovative in vitro assay for the classification of skin sensitizers that permits evaluation of chemicals within the highly relevant context of a three-dimensional model of human skin that more closely mimics the… more
Abstract:DESCRIPTION (provided by applicant): Human health has benefited tremendously from the therapeutic application of monoclonal antibodies (mAb), treating painful and devastating diseases such as rheumatoid arthritis and cancer, among others. However, mAb development is a laborious and time consuming… more
Abstract:DESCRIPTION (provided by applicant): Remarkable improvements in throughput, accuracy and cost-effectiveness of next-generation sequencing (next-gen) technologies are ushering in a new era of clinical medicine. Genome wide association studies (GWAS) in particular have begun to leverage these advances… more
Abstract:Convincing scientific evidence has associated dietary choices with chronic disease expression. Dietary guidelines now in place are designed to prevent the onset of such chronic diseases as tissue-specific cancers, cardiovascular diseases, and osteoporosis. The cornerstone of recommended dietary… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop a real-time ultrasound system for evaluating musculoskeletal soft tissue conditions by implementing the novel ultrasound post-processing software developed in Phase I into a programmable platform ultrasound system.… more
Abstract:ABSTRACT: An instrument measuring volume charges in thin dielectric films is proposed. The instrument utilizes an enhanced Pulsed Electro-Acoustic (PEA) technique and delivers submicron spatial and at least 0.1 micro-Coulombs per cubic centimeter resolutions of the charge density. Traditional PEA… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will develop and commercialize an integrated system to actively stabilize an optical microscope to the precision required by today's cutting-edge imaging methods. Microscopy in the biological sciences is undergoing radical… more
Abstract:Purpose: Prior research demonstrates that younger students who are low- or non-verbal often have difficulty independently practicing skills that provide a foundation for early literacy. The proposed product will provide support to students who are low- or non-verbal to independently practice phonics… more
Abstract:DESCRIPTION (provided by applicant): Patient socket performance is a critical barrier to progress in rehabilitation, the most common source of patient dissatisfaction and part of a growing medical and socioeconomic problem. Poor socket performance is a greatly uncharacterized multi-factorial… more
Abstract:DESCRIPTION (provided by applicant): Our companys' goal is to create and commercialize a modular, immediate fit, transtibial prosthesis system at a fraction of the cost of conventionally manufactured devices. Our product will be mass produced using the latest injection molding techniques with… more
Abstract:USDA secretary, Tom Vilsack, has urged the Forest to prioritize "protecting and maintaining all American Forests, including state and private lands. ... The Forest Service must play a significant role in the development of new markets and ensure their integrity." Small-diameter round… more
Abstract:We propose to design and implement a set of CAD queries by which to achieve model interchangeability in assemblies, model interoperability, and model integration for CAD/CAE. A model scenario will be used to illustrate how this can be accomplished. In Phase 1, we will establish the feasibility of… more
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