Abstract:This Small Business Technical Transfer (STTR) Phase I project will demonstrate the potential for developing a novel affinity binding reagent screening technology. Synthetic affinity binding reagents can improve on immunoglobulin-based antibodies. For example, synthetic affinity binding reagents are… more
Abstract:The unique built-in design features of the proposed mini pulse tube cryocooler avoid all thermal expansion issues enabling it to operate within a cold, 150 K environment. As such, the cooler addresses the need to prevent boiloff of cryogenic propellants on long duration remote missions.Due to its… more
Abstract:PROJECT SUMMARY/ABSTRACT My Coverage Plan Inc. (MCP) proposes to use our newly patented technology to create a commercially viable and nationally replicable suite of software and services for health care providers and other social service agencies that reduces avoidable health disparities and… more
Abstract:This Small Business Innovation Research (SBIR) Phase 1 project will develop an ultra-low power reconfigurable hardware watchdog preprocessor for identifying and acting upon spatial and temporal trigger signatures (events of interests) in continuous sensory data streams. The proposed approach… more
Abstract:Blood-based assays require upstream mechanisms to acquire sample from a patient, extract the analyte of interest, and preserve the analyte until it can be quantified. Current point-of-care assays overwhelmingly rely on lancet puncture, which is inconvenient because of the presence of blood that is… more
Abstract:DESCRIPTION (provided by applicant): Economic, logistical, and physical barriers limit HIV viral load quantification, the gold standard for HIV diagnostics. The cost of the test is high (approximately 100 per test) and the intricate equipment required limits testing to laboratories staffed by… more
Abstract:The project team is developing a prototype of an application (app) for a tablet computer called Access: Language Arts. The app will support middle school students with significant learning disabilities in meeting Common Core State Standards in English Language Arts. The intervention will be designed… more
Abstract:Significance: Accurate targeting, guidance and monitoring of interventional therapy in the brain are critical for maximizing the effectiveness and safety during and following neurosurgical procedures. Magnetic resonance imaging (MRI) is a critical tool forplanning and guiding neurosurgical… more
Abstract:DESCRIPTION (provided by applicant): Healing of Diabetic Ulcers with Gaseous Nitric Oxide Generated from Room Air Diabetic foot ulcers (DFUs) are a frequent and debilitating complication of diabetes, and affect 1-2.5 million patients in the US. Many DFUs remain unhealed, leading to extensive… more
Abstract:DESCRIPTION (provided by applicant): The objective of this Phase I SBIR project is to design, develop and evaluate a wearable Muscle Fiber Excitation System (MFES) for preventing blood clot in immobilized patients during convalescence following lower limborthopedic surgery. The MFES device will be… more
Abstract:Facing strict effluent limits, municipal wastewater treatment facilities are dealing with increasing costs of treating phosphorus in their waste. Current technologies are capable of sequestering the phosphorus in an unusable form or capturing only a fraction of it. Nutrient Recovery and Upcycling,… more
Abstract:The technical objectives of this proposal are: 1) the design of 3.0-3.5 micron-emitting quantum cascade laser (QCL) structures grown on metamorphic-buffer-layer (MBL) substrates; 2) the realization of electroluminescent QCL structures on MBLs with emission in the 3.0-3.5-micron wavelength range.… more
Abstract:The technical objectives of this proposal are: 1) Implement the design developed in Phase I for the realization of 8 micron-emitting active-photonic-crystal (APC) quantum-cascade (QC) lasers of 3 W average, diffraction-limited power and 15 % wallplug efficiency in quasi-CW operation; 2) Design and… more
Abstract:Democracy relies on informed and active participation of citizens. This project team is developing a prototype of a formative assessment component to be added to the GoCivics games, a tablet-based intervention through which middle school students engage in compelling learning activities and… more
Abstract:Studies show that many American students do not possess basic knowledge of the America judicial branch of government, one of three pillars upon which democracy rests. This project team is developing a prototype of the GoCivics Mock Trial, a multiplayer, augmented reality, role-playing game for use… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will produce a set of engaging educational video games and associated teaching compendiums for middle school physical science classrooms that are optimized for students with diverse sets of learning needs, including those with learning… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop a platform for the production of spider silk fibroins in plant trichomes. Synthetic spider silk has great potential as an environmentally-friendly biomaterial because it is very flexible yet has a tensile strength… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will investigate the feasibility of utilizing a stabilized, cadmium-binding antibody to sequester cadmium in plant trichomes. Heavy metals such as cadmium are ubiquitous contaminants in soil surrounding… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project seeks to increase the cycle life of cathode materials used in lithium-ion batteries by a factor of ten in high-temperature applications by applying protective nanoporous ceramic coatings. SolRayo will investigate the effects that… more
Abstract:DESCRIPTION (provided by applicant): Approaches to drug screening typically involve dramatic compromises in order to achieve high throughput and hold down costs. Examples include the use of immortalized, heterologous cell lines, and genetic engineering toover-express the target protein and/or… more
Abstract:DESCRIPTION (provided by applicant): Cardiotoxicity, as a result of adverse drug effects, is a serious problem that has yet to be effectively screened prior to patient exposure. Cardiac safety is one of the leading causes of compound attrition in the pharmaceutical industry and withdrawal of… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to complete development of a universal, in vitro assay for determining the enzymatic activity of botulinum neurotoxin (BoNT)-based pharmaceuticals. This assay, called BoTest Matrix A Assay, will enable standardized comparisons… more
Abstract:Each week, in total, 338 small and mid-sized farms ($1,000-500,000 in revenue) go out of business despite the undeniable demand for local food. This proposal will work with a state department of agriculture to research the viability of real-time price sheet marketing, as compared to static… more
Abstract:DESCRIPTION (provided by applicant): The internet is an increasingly important resource for clinicians to access training materials and resources for treatment delivery of evidence-based treatments such as cognitive behavioral therapy (CBT) and antidepressant medications. This project proposes to… more
Abstract:DESCRIPTION (provided by applicant): More efficient methods to screen and monitor elderly patients in clinical practice and research are needed, but visits to clinical offices are expensive and many older patient are restricted by mobility or transportation access. The Alzheimer's Disease… more
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