Abstract:DESCRIPTION: In this proposal, Comfort Care for Animals LLC (CCA) (Madison, WI) will create slow-release (minimum 10-12 days in this Phase, with an ultimate goal of 28 days) injectable liposomal buprenorphine formulation to treat moderate to severe post-surgical or chronic pain in people and… more
Abstract:DESCRIPTION (provided by applicant): Swallowing disorders, known as dysphagia, are associated with increased mortality and morbidity, including malnutrition, dehydration, pulmonary complications, and reduced quality of life. More than 18 million adults (and millions more children) suffer from… more
Abstract:Blood-based point-of-care (POC) diagnostics or remote diagnostics that require specialized equipment only available in centralized, commercial laboratories are currently limited by major logistical and technical barriers. Blood collection can be a traumatic, inconvenient, and inconsistent process… more
Abstract:Facing strict effluent limits, municipal wastewater treatment facilities are dealing with increasing costs of treating phosphorus in their waste. Current technologies are capable of sequestering the phosphorus in an unusable form or capturing only a fraction of it. Nutrient Recovery and Upcycling,… more
Abstract:Existing high current negative ion sources have unacceptably short lifetimes. In this Phase II project, a long lifetime, high reliability H- ion source capable of delivering current greater than 10 mA will be constructed, built, and tested. Feasibility was proven and preliminary designs were… more
Abstract:DESCRIPTION (provided by applicant): Aptamer-Based Detection of Cardiac Biomarker Glycosylation States Using APT-SNAP Arrays PIs: Christopher L. Warren and Mary S. Ozers The presence of cardiac-related biomarkers in patient biospecimens can provide important insight into diagnosis of cardiovascular… more
Abstract:The technical objectives of this proposal are: (1) design a grating-coupled surface-emitting (GCSE) active-photonic-crystal (APC) 4.6 micron-emitting quantum-cascade laser (QCL) to deliver 15 W diffraction-limited CW power in the main lobe of the far-field beam pattern; (2) design a GCSE-APC QCL… more
Abstract:The technical objectives of this proposal are: 1) Design a metal/semiconductor grating-based (i.e., substrate-emitting) Grating-Coupled Surface-Emitting Distributed Feedback Quantum Cascade Laser (GCSE-DFB QCL) emitting at 4.6 microns with high beam quality; and 2) Demonstrate a GCSE-DFB QCL… more
Abstract:GoGames will be a tablet-based multiplayer role-play game for middle school social studies classrooms and will focus on topics in civics. GoGames is intended to enable more efficient and effective implementation of traditional civics interventions by replacing static paper content and training… more
Abstract:DESCRIPTION (provided by applicant): This application, Imaging Software of Functional Connectivity MRI for Alzheimer's Disease , is written in response to (PA-11-134) Lab to Marketplace: Tools for Brain and Behavioral Research (SBIR [R43/R44]) . Alzheimer's disease (AD) is the most… more
Abstract:DESCRIPTION (provided by applicant): Standard Imaging, Inc. is developing a new generation of radiation dosimeters for small field dosimetry. These small detectors are needed in clinical applications such as stereotactic radiosurgery/stereotactic radiotherapy (SRS/SRT), intensity modulated radiation… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to design and prototype a dynamic physical model of DNA that students will use in an active learning environment to explore the 3-D structure of double- stranded DNA - and then easily untwistinto a flat, 2-D ladder model in which the… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop a new signal amplification system that, while being inexpensive and simple to use, can be combined with antibodies or other probe molecules and can increase detection limits of conventional Enzyme-linked… more
Abstract:Frederick T. Elder & Associates(FTEA) proposes an approach to the development of a closed-cycle Helium-Rubidium(He-Rb) circulator that allows for FTEA to ensure safety throughout the project, to manufacture a prototype at a reasonable cost using mostly commercial components if selected for Phase… more
Abstract:DESCRIPTION (provided by applicant): Experimental manipulation of gene expression is a widely used technique that is crucial to much of modern biomedical research. The ability to control the timing and expression level of recombinant genes is central to the production of recombinant protein for… more
Abstract:DESCRIPTION (provided by applicant): The genetic basis of disease remains a significant research problem, impacting the fields of cancer biology, neurology, cardiology, development, and even microbiology, as recently realized by the Human Microbiome Project. Determination of the genomic sequence… more
Abstract:Respiratory tract infection in pigs, commonly referred to as "Porcine Respiratory Disease Complex (PRDC)", is one of the major challenges for the swine industry, as PRDC causes significant economic losses to swine producers worldwide. Rapid detection of causative agents is the key to… more
Abstract:The Zero G Mass Measurement Device (ZGMMD) will provide the ability to quantify the mass of objects up to 2,000 grams, including live animal specimens in a zero G environment, an innovative because there currently are no such devices available to perform mass measurement of smaller masses (<2000… more
Abstract:ORBITEC proposes to develop and demonstrate an Integrated Composite Rocket Nozzle Extension (ICRNE) for use in rocket thrust chambers. The ICRNE will utilize an innovative bonding approach to join a high-temperature composite nozzle extension to a regeneratively cooled metallic nozzle. The ICRNE… more
Abstract:ORBITEC proposes to develop and demonstrate the innovative Acoustic Resonance Reaction Control Thruster (ARCTIC) to provide rapid and reliable in-space impulse without the use of toxic hypergols, delicate catalyst beds, or cumbersome spark systems. The ARCTIC thruster will exceed current reliability… more
Abstract:ORBITEC, in collaboration with Lucigen, proposes a rapid nucleic acid-based detector for spaceflight water systems to enable simultaneous quantification of multiple waterborne pathogens with minimal consumables and crew time. The Rapid Multiplex Microbial Detector (RMMD) amplifies the genetic… more
Abstract:Advanced ordnance and propulsion systems utillize materials, such as RDX and HMX, that provide good performance but cannot meet today"s more stringent safety and environmental requirements. Unfortunately, in newer compounds created to replace them, the performance falls with the sensitivity.… more
Abstract:Convincing scientific evidence provides the association between dietary choices and chronic disease expression. Dietary guidelines now in place are designed to prevent the onset of such chronic diseases as tissue-specific cancers, cardiovascular diseases, and osteoporosis. The cornerstone of… more
Abstract:In this work, a long lifetime (greater than 6 months) H- ion source capable of reliably delivering current greater than 10 mA will be designed. The immediate DoE need for this technology is a reliable DC H- ion source that will inject an ion beam into the proposed Project X particle accelerator at… more
Abstract:Phoenix Nuclear Labs (PNL) will perform a comprehensive analysis of all existing and proposed neutron generator technologies that do not utilize highly enriched fissile material. These technologies include the flux compression generator, dense plasma focus, high current deuterium-tritium fusion,… more
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