Abstract:DESCRIPTION (provided by applicant): 100,000 Americans perish each year due to untreatable bacterial infections. The societal benefits of new antibiotic compounds that are effective against numerous multiple drug resistant pathogens would be significant. The best possible source for new antibiotic… more
Abstract:DESCRIPTION (provided by applicant): A major goal in the post-genomic era is to express the vast collection of protein- coding sequences, eventually resulting in a better understanding of protein interactions and the development of novel therapeutics. Themost favored host for heterologous… more
Abstract:DESCRIPTION (provided by applicant): Each year, 100,000 Americans perish due to untreatable bacterial infections. The societal benefits of new antibiotic compounds that are effective against numerous multiple drug resistant pathogens would be significant.The best possible source for new antibiotic… more
Abstract:DESCRIPTION (provided by applicant): Robust expression of multi-subunit protein complexes is crucial for understanding the basic biology of organisms. Expression of the individual components in E. coli or yeast may be quick and cost-efficient, but many mammalian proteins show poor expression or… more
Abstract:DESCRIPTION (provided by applicant): Monoclonal antibodies (mAbs) have been developed into a highly effective class of therapeutic molecules, with global growth of 37% between 2001 and 2002. Since their discovery in 1975, mAbs have been described as magic bullets with the potential to seek out… more
Abstract:ABSTRACT: Study of non-stationary phenomena in turbulent combusting flows requires spatial measurements of a set of parameters at kHz rates. Ideally these parameters would include the velocity , temperature, and a relevant species concentration. In response to this need, ORBITEC and the… more
Abstract:ORBITEC's Non-Thermal Sanitation by Atmospheric Pressure Plasma technology sanitizes fresh fruits and vegetables without the use of consumable chemicals and without significantly raising the temperature of the food, so food taste and quality are not affected. Atmospheric pressure plasma is well… more
Abstract:ORBITEC proposes to develop and demonstrate a novel cooling concept called Lattice Regenerative Cooling Methods (LRCM) for future high thrust in-space propulsion systems. Incorporation of ORBITEC's innovative lattice structures in the fabrication of thrust chambers for expander cycle engine… more
Abstract:ORBITEC, in collaboration with Lucigen, proposes a rapid genetic detector for spaceflight water systems to enable real-time detection of E. coli with minimal consumables and crew time. The Rapid Coliform Detector (RCD) amplifies the genetic material in a liquid sample to allow near real-time… more
Abstract:ORBITEC proposes to develop non-toxic propulsion systems to replace hyradzine-derivative systems in interceptor applications. In ongoing work, ORBITEC has been developing high-performance ionic liquid fuels. These inherently non-volatile fuels promise safer, less sensitive systems while providing… more
Abstract:ABSTRACT: ORBITEC proposes to develop the Cooling Channel Diagnostic System (CCDS), a diagnostic tool for assessing the condition of rocket engine cooling channels. This system will be used to detect and locate any deposits which inhibit heat transfer between cooling channels and the hot-gas wall… more
Abstract:ABSTRACT: ORBITEC proposes to develop a hybrid cycle to improve the overall performance and reduce the cost of advanced upper stage engines. Upper stage engines using the High Performance Hybrid Cycle (HPHC) will have the benefits of compact design, high thrust-to-weight, and high Isp. Once… more
Abstract:ORBITEC proposes to develop the Advanced Reversible Cryogenic Thermal Energy Storage (ARCTES) system, which will provide temporary backup cooling for circulating helium gas coolant in high-temperature superconducting (HTS) systems for naval applications. The ARCTES will rely on an initially-frozen… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will lead to the development of a new class of liquid crystal (LC)-based direct-read monitors (DRMs) for detection of nitrogen dioxide (NO2) present in air at construction sites. The approach to development of DRMs that is described in… more
Abstract:DESCRIPTION (provided by applicant): Primorigen Biosciences SBIR Proposal Abstract Primorigen Biosciences will use SBIR funds to develop an advanced cell culturing methodology to increase the efficiency of directed differentiation and to boost functional maturity of induced pluripotent stem… more
Abstract:DESCRIPTION (provided by applicant): Primorigen Biosciences will develop an enhanced cell culturing technology that dramatically increases proliferative and differentiation capabilities of human bone-marrow derived mesenchymal stem cells (hMSC's) for neural induction, and ultimately for… more
Abstract:DESCRIPTION (provided by applicant): Schizophrenia is a chronic and debilitating disorder that impacts nearly 1% of the world's population. The burden on the families and caregivers of patients is immense, with the cost of care in the United States being greater than 60 billion annually. The… more
Abstract:DESCRIPTION (provided by applicant): Scarab Genomics has developed valuable reduced-genome strains of Escherichia coli in which multiple deletions remove from the genome much unwanted and all potentially hazardous DNA. These Clean Genome(R) strains, alongwith Scarab's gene expression technology… more
Abstract:DESCRIPTION (provided by applicant): Biotherapeutics is a fast-growth sector in the pharmaceutical market with monoclonal antibodies accounting for almost 50% of the 100 billion USD spent each year on protein therapies. Bacterial fermentation, which accounts for about 35% of all protein therapeutics… more
Abstract:DESCRIPTION (provided by applicant): In today's biopharmaceutical pipeline, monoclonal antibodies (mAbs) are a predominant modality for a broad range of clinical indications including oncology and inflammatory diseases. Most antibody therapies have to be administered to the patients in large… more
Abstract:Complex skin defects, including burns and trauma, represent a major medical problem affecting both military and civilian populations. In recent military engagements, burns account for approximately 5% of combat casualties. Furthermore, approximately 1.25 million Americans each year require medical… more
Abstract:DESCRIPTION (provided by applicant): The ultimate goal of this project is to develop an innovative in vitro assay for the classification of skin sensitizers that permits evaluation of chemicals within the highly relevant context of a three-dimensional model of human skin that more closely mimics the… more
Abstract:DESCRIPTION (provided by applicant): Human health has benefited tremendously from the therapeutic application of monoclonal antibodies (mAb), treating painful and devastating diseases such as rheumatoid arthritis and cancer, among others. However, mAb development is a laborious and time consuming… more
Abstract:DESCRIPTION (provided by applicant): Remarkable improvements in throughput, accuracy and cost-effectiveness of next-generation sequencing (next-gen) technologies are ushering in a new era of clinical medicine. Genome wide association studies (GWAS) in particular have begun to leverage these advances… more
Abstract:Convincing scientific evidence has associated dietary choices with chronic disease expression. Dietary guidelines now in place are designed to prevent the onset of such chronic diseases as tissue-specific cancers, cardiovascular diseases, and osteoporosis. The cornerstone of recommended dietary… more
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