Abstract:Computherm proposes to develop PANDA, an innovative and user-friendly computer program integrated with a thermodynamic database, to provide a significant new capability to rapidly determine multi-component phase diagrams needed to identify novel high-temperature structural materials. The lack of… more
Abstract:We will commercialize a high-sensitivity, low-cost fluorescence- based DNA fragment analyzer with atimes higher throughput than current instruments. Such an instrument is essential to accelerating ouand other heritable diseases by making it cost-effective to perform large-scale genetic linkage… more
Abstract:Managed care organizations require primary care physicians to triage patients for skin cancer, yet many primary care physicians are unable to proficiently perform this function. Data suggest that primary care physicians correctly identify cancerous lesions less than 50% of the time, resulting in… more
Abstract:The NIH sponsored Diabetes Control and Complications Trial (DCCT study) clearly demonstrates that lglucose control dramatically slows down the onset of the devastating complications of diabetes. Howeglucose control is both difficult and potentially hazardous. Hypoglycemia occurs 2-3 times more… more
Abstract:An optically actuated speaker suitable for fabrication as an array in headphones is proposed. These speakers provide good fidelity in a package with a flat profile because of the speaker element array structure. Fabricated as an all optical device using fiberoptic inputs the device is also immune… more
Abstract:Anti-sense technologies hold tremendous promise for the treatment of a wide range of disease that include cancer, infectious diseases and dominant genetic disorders. Despite the tremendous promise of this approach, there have been few clear successes. In order for anti- sense therapy to reach the… more
Abstract:ORBITEC proposes to develop an Advanced Cryogenic Hybrid Rocket Engine (ACHRE) that can be used by the USAF/Phillips Laboratory to test the performance of high-energy propellants from the USAF-funded program. The innovative design is based upon the knowledge and experience gained in developing,… more
Abstract:ORBITEC will develop an Environmental Stress Measurement Device (ESMD) for missile applications.previous technology efforts in time stress meausurement devices and microelectromechanical sensors (MEMS) will be leveraged to develop and design an ESMD capable of self-powered autonomous operation for 5… more
Abstract:The Infrared Fire Detector and Alarm (IRFDA) is proposed to provide the United States Air Force with a system that is capable of detecting fire in large aircraft hangars, also in proximity of fuel, ammunition and other hazardous material storage areas. The IRFDA system will be a cost effective,… more
Abstract:A Micro-Turbojet system is vastly reduced in size, on the order of 1.0-10cm diameter with thrust from .051b to 8lbs. Micro-electronics machining (MEM) techniques are used to produce augmentation unit that is fitted to an existing successful micro-turbojet(5.0 inch diameter, 35 lbs thrust),… more
Abstract:This Small Business Innovation Research Phase I project will investigate the feasibility of an innovative concept in high-speed closed-loop feedback control systems for piezoelectric positioners used in precision manufacturing. There is considerable use, and considerably greater potential for… more
Abstract:This SBIR Phase I project will investigate the feasibility of an improved control strategy for piezoelectric positioners used in scanned-probe microscopes (SPMs) to increase their speed and reliability for nanocharacterization. Rapid nanocharacterization requires fast motion of the scanned piezo… more
Abstract:DESCRIPTION (Adapted from applicant's abstract): Our understanding of the molecular control of neuronal function and synaptic transmission is limited because studies are performed using high resolution molecular genetic approaches within the limits of diffraction limited optical microscopy. To… more
Abstract:CURRENT LUMINESCENCE BIOASSAYS RELY SOLELY UPON MESUREMENT OF LUMINESCENCE INTENSITY TO GENERATE INFORMATION. MULTIPLE COLORS FROM BEETLE LUCIFERASE HAS CREATED THE OPPORTUNITY TO INCREASE ASSAY INFORMATION CONTENT BY USING MULTIPLEXING TECHNIQUES TO MEASURE LIGHT INTENSITIES AT DIFFERENT… more
Abstract:This proposal describes strategies to synthesize potent inhibitors of botulinum neurotoxin metalloproteases. These metalloproteases [BoTx protease] have been shown to be the molecular effectors of the paralytic effects of these toxins. Mechanism-based drug design will be applied to develop… more
Abstract:41294 November 19, 1996
DNA sequence information is the cornerstone for considerable experimental design and analysis in the biological sciences, but it is time consuming and expensive. The project will focus on advancing DNA sequencing… more
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