Abstract:CURRENT LUMINESCENCE BIOASSAYS RELY SOLELY UPON MESUREMENT OF LUMINESCENCE INTENSITY TO GENERATE INFORMATION. MULTIPLE COLORS FROM BEETLE LUCIFERASE HAS CREATED THE OPPORTUNITY TO INCREASE ASSAY INFORMATION CONTENT BY USING MULTIPLEXING TECHNIQUES TO MEASURE LIGHT INTENSITIES AT DIFFERENT… more
Abstract:This proposal describes strategies to synthesize potent inhibitors of botulinum neurotoxin metalloproteases. These metalloproteases [BoTx protease] have been shown to be the molecular effectors of the paralytic effects of these toxins. Mechanism-based drug design will be applied to develop… more
Abstract:41294 November 19, 1996
DNA sequence information is the cornerstone for considerable experimental design and analysis in the biological sciences, but it is time consuming and expensive. The project will focus on advancing DNA sequencing… more
Abstract:This Phase I research will create improved software tools for spreading climate and terrain information over a surface. Implementation of state-of-the-art methodologies for interpolation and extrapolation will increase the usefulness of georeferenced data. Useful directions to pursue will be… more
Reduced Model Authoring: A Unique Interface To Electromagnetic Analysis--Simulation Technology & Applied Research, 5020 West Century Court, Mequon, WI 53092-1195;
Dr. John F. DeFord, Principal Investigator
Dr. John F. DeFord, Business Official
DOE Grant No.… more
Abstract:Synchrotek Inc. proposes to design, during Phase I, a 10 kW and a 20kW generator for application as a power unit for HMMWV and other light tactical vehicles. The generator will be desinged in an "in-Line" configuration, mounted between the engine and the transmission of the vehicle. The frame of… more
Abstract:It is now well established that 1alpha, 25-dihydroxyvitamin D3 not only mediates calcium homeostasisignificant cellular activity in tissues not related to calcium homeostasis. This seco-Suiteroid horpromote cellular differentiation and inhibit proliferation in a number of normal and malignant… more
Abstract:The technology of thermal spraying will be used as the basis for developing a novel process of producing printed wiring boards. Thermal spraying of copper onto engineered plastic substrates that have been masked to expose a wiring pattern will be demonstrated as an efficient and environmentally… more
Abstract:This Small Business Innovation Research Phase I project will develop commercial biorestoration technologies to restore the overall structure and function of degraded Sphagnum weland ecosystems. Technologies will include the development of plant tissue culture techniques for Sphagnum species, the… more
Abstract:While the Internet may promise the potential of increased access to services and information, obstacles make access to such technology by rural businesses, educators and individuals difficult.
Much research has been conducted about bringing Internet services into K-12 education, and projects have… more
Abstract:A portable fluorometric spectral analyzer for rapid field or shipboard diagnosis of Campylobacter enteritis and Shigella dysentery Is proposed for Phase I feasibility demonstration. All living cells are fluorescent and exhibit "fingerprint" spectral patterns that allow for their detection and… more
Abstract:We propose to validate the feasibility of expression in bovine milk of recombinant protein sweetener, following gene delivery by intramammary infusion of a replication defective viral vector. The sweet protein Brazzein is a natural plant product which has been isolated and characterized and for… more
Abstract:Research is providing increasing evidence of the potential therapeutic effectsof the physical environment for people with dementia in long-term care settings. Despite this, facilitieshave limited options for learning how to create more supportive environments. Hence few facilities areincorporating… more
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